PFOS Exposure Impairs Porcine Oocyte Maturation and Embryo Development via Mitochondria-Dependent Ferroptosis DOI
Xiaoqing Sun, Ran Teng, Ning Xu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126185 - 126185

Published: April 1, 2025

Language: Английский

Role of hepatocyte-specific FOXO1 in hepatic glucolipid metabolic disorders induced by perfluorooctane sulfonate DOI

Jing Yang,

Longfei Li,

Ziwen An

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 367, P. 125632 - 125632

Published: Jan. 2, 2025

Language: Английский

Citations

0
Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis DOI Creative Commons
Ningning Yang, Kun Jia, Kazuoki Dai

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117964 - 117964

Published: March 1, 2025

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant that induces inflammatory response and oxidative stress in oral mucosa. Ferroptosis, form of cell death characterized by iron-dependent lipid peroxidation (the degradation lipids), was believed to play crucial role pathogenesis mucositis; however, the involvement PFOS-induced ferroptosis remained unclear. Our findings demonstrated PFOS inhibited proliferation induced pro-apoptotic effects cells, with most pronounced observed human keratinocytes (HOK). significantly increased reactive oxygen species (ROS) peroxidation, depleted glutathione (GSH) HOK cells. Notably, decreased peroxidase 4 (GPX4) expression elevated Fe2 + levels, suggesting potential induction ferroptosis. Ferroptosis inhibitors mitigated GSH depletion, subsequently enhancing viability. Mechanistically, endoplasmic reticulum (ER) contributed nuclear translocation (from cytoplasm into nucleus) activating transcription factor (ATF4) up-regulated its downstream target gene Chac1. Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) catalyzed conversion cysteinylglycine 5-oxoproline, resulting depletion-a critical Knocking down CHAC1 attenuated Tauroursodeoxycholic acid (TUDCA), classical ER inhibitor, mucositis inhibiting ATF4/CHAC1 pathway activation. These elucidated toxicological mechanisms proposed therapeutic strategies counteract exposure mucositis.

Language: Английский

Citations

0
New insights into DEHP-induced inflammatory injury in chicken spleen: ROS/TLR4/MyD88 pathway and apoptosis/necroptosis-M1 polarization crosstalk DOI Creative Commons
Yue Xu,

Xiandan Zhang,

Guangxing Li

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105074 - 105074

Published: March 1, 2025

Language: Английский

Citations

0
PFOS Exposure Impairs Porcine Oocyte Maturation and Embryo Development via Mitochondria-Dependent Ferroptosis DOI
Xiaoqing Sun, Ran Teng, Ning Xu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126185 - 126185

Published: April 1, 2025

Language: Английский

Citations

0