Examining the Relationship Between Persistent Organic Pollutants and Metabolic-Associated Fatty Liver Disease: A Cross-Sectional Analysis Using NHANES Data

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Recently, the term Metabolic-Associated Fatty Liver Disease (MAFLD) has been adopted to better reflect underlying pathology and association with metabolic issues. Beyond dietary factors physical activity, previous studies have suggested that persistent organic pollutants (POPs), may contribute etiology of MAFLD; however, this disease can also develop at very low POP exposure levels, making it challenging discern their specific effect. This study aims investigate potential link between POPs, prevalence MAFLD. Data from National Health Nutrition Examination Survey (NHANES) was utilized for cross-sectional study. Participants were categorized based on MAFLD status levels various POPs measured in blood serum. Cox regression estimate adjusted ratio (aPR) used. Hazard Index (HI), Proportion Maximum Scaling (POMS), Toxicity Burden (TBI) applied assess mixtures. A total 4,224 participants included, 47 (33–65) years, 53.0% women, 50.1% had No significant sex differences observed main analysis regarding individual prevalence. However, sensitivity analyses revealed an inverse relationship certain prevalence, particularly women. Higher PCBs associated a lower highlighted effects pollutants, mixtures, sex-specific differences. The combined use HI, POMS, TBI provided more detailed risk assessment. Findings suggest biological stressors play roles how influence MAFLD, warranting further investigation into mechanisms health outcomes different ranges.

Language: Английский

SOCS3 Methylation Partially Mediated the Association of Exposure to Triclosan but Not Triclocarban with Type 2 Diabetes Mellitus: A Case-Control Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12113 - 12113

Published: Nov. 11, 2024

This study aimed to evaluate the association of TCs (triclosan (TCS) and triclocarban) exposure with T2DM glucose metabolism-related indicators mediating effect

Language: Английский

Studi Molecular Docking Senyawa Ircinianin Terhadap Reseptor Sodium-Glukose Co-Transporter 2 (SGLT-2)

FASKES Jurnal Farmasi Kesehatan dan Sains, Journal Year: 2024, Volume and Issue: 2(2), P. 1 - 7

Published: Nov. 30, 2024

Latar Belakang: Sodium-glucose cotransporter 2 (SGLT-2) merupakan target potensial dalam pengobatan diabetes tipe 2, dengan inhibitor SGLT-2 yang bekerja menghambat reabsorpsi glukosa di ginjal. Penelitian ini bertujuan untuk mengevaluasi potensi ircinianin, senyawa alami diisolasi dari spons Ircinia sp., sebagai menggunakan pendekatan molecular docking. Tujuan: menganalisis interaksi antara ircinianin dan protein serta penghambatan terhadap reseptor SGLT-2. Metode: Metode digunakan adalah docking perangkat lunak AutoDock4. Prosedur dilakukan ligan pada situs aktif Ligan didocking 100 iterasi memperoleh konformasi ikatan optimal. Interaksi dianalisis berdasarkan energi visualisasi Discovery Studio. Hasil: Ircinianin menunjukkan sebesar -10,76 kcal/mol, sedikit lebih tinggi dibandingkan native ligand (-11,46 kcal/mol). membentuk dua hidrogen residu PHE:98 TRP:291. Kesimpulan Saran: memiliki SGLT-2, meskipun hidrogennya asli. lanjut diperlukan mengeksplorasi terapeutik 2.