THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Environmental Toxicants and Their Disruption of Integrin Signaling in Lipid Rafts DOI Open Access
Tina Izard

BioEssays, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Talin, a key integrin activator, is essential for cellular adhesion, signal transduction, and mechanical stability. Its transition between autoinhibited active conformations allows dynamic regulation of adhesion in response to environmental cues. Cholesterol-rich membrane microdomains, such as lipid rafts, organize stabilize signaling platforms, influencing talin conformational states. Cholesterol switch modulating activation, binding, adhesion. Environmental pollutants, including heavy metals air toxins, disrupt cholesterol homeostasis, destabilize interfere with talin-integrin interactions. These disruptions impair tissue repair, fidelity, contributing atherosclerosis cancer metastasis. Understanding talin's interaction cholesterol-rich domains offers critical insights into reveals the broader impact toxicants on function. This framework emphasizes importance composition, particularly cholesterol, mediating effects stressors suggests potential therapeutic interventions.

Language: Английский

Citations

1
An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis DOI
Akmaral Baspakova, Afshin Zare,

Roza Suleimenova

et al.

Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 101, P. 101336 - 101336

Published: Jan. 4, 2025

Language: Английский

Citations

0
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Citations

0
THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

Citations

0