Dietary quorum quenching AHL lactonase impairs the adaptation of commensal bacterium to host innate immunity DOI Open Access
Rui Xia, Yuanyuan Yao, Delong Meng

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Quorum sensing (QS) is the communication system of bacteria that depends on QS signals. quenching (QQ) enzymes degrade signals and are promising alternatives antibiotics to treat bacterial infections. Here, we found dietary QQ N -acyl homoserine (AHL) lactonase led microbiota dysbiosis in zebrafish, with reduction Aeromonas enrichment Plesiomonas . Through gnotobiotic zebrafish colonized a minimal microbiota, QQ-mediated microbial alteration relies host Myd88 signaling neutrophil elastase. Mechanistically, quorum increased susceptibility commensal elastase by impairing lateral flagellar system, leading reduced colonization subsequent due ecological competition two species. Together, adaptation innate immunity, which provided novel insight role host-microbiota interaction.

Language: Английский

Dietary quorum quenching AHL lactonase impairs the adaptation of commensal bacterium to host innate immunity DOI Open Access
Rui Xia, Yuanyuan Yao, Delong Meng

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Quorum sensing (QS) is the communication system of bacteria that depends on QS signals. quenching (QQ) enzymes degrade signals and are promising alternatives antibiotics to treat bacterial infections. Here, we found dietary QQ N -acyl homoserine (AHL) lactonase led microbiota dysbiosis in zebrafish, with reduction Aeromonas enrichment Plesiomonas . Through gnotobiotic zebrafish colonized a minimal microbiota, QQ-mediated microbial alteration relies host Myd88 signaling neutrophil elastase. Mechanistically, quorum increased susceptibility commensal elastase by impairing lateral flagellar system, leading reduced colonization subsequent due ecological competition two species. Together, adaptation innate immunity, which provided novel insight role host-microbiota interaction.

Language: Английский

Citations

0