Comparative Analysis of Metabolic Dysfunctions Associated with Pristine and Aged Polyethylene Microplastic Exposure via the Liver-Gut Axis in Mice DOI
Haiyan Cui, Xiaofeng Jiang, Jing Cao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

The accumulation of plastic waste in the environment has raised widespread concern about impact microplastics (MPs) on human and environmental health, particularly regarding aged MPs. This study investigated effects subchronic dietary intake pristine polyethylene (PE-MPs) C57BL/6J mice. Results revealed that both PE-MPs, at doses 0.01 1 mg/day, induced plasma metabolic changes primarily associated with lipid metabolism digestive processes. These alterations were reflected expression proteins involved unsaturated fatty acid pathways liver as well a reduction beneficial gut microbiota. Key contributors toxicity PE-MPs included ATP-binding cassette transporters, bacteria (notably Lactobacillus, Akkermansia, Parasutterella, Turicibacter), significantly altered related to elongation, such acyl-CoA thioesterase enzyme family elongation very long chain protein 5. disruptions exacerbated disorders, potentially contributing diseases. Additionally, decreased levels glutathione S-transferase A proteins, along reduced hepatic increased reactive oxygen species small intestine liver, suggested aggravated intestinal damage through oxidative stress. findings indicated caused more severe dysfunction microbiota disruption. effect was likely mediated by transfer acids signaling molecules gut-liver axis, ultimately leading disorders

Language: Английский

Comparative Analysis of Metabolic Dysfunctions Associated with Pristine and Aged Polyethylene Microplastic Exposure via the Liver-Gut Axis in Mice DOI
Haiyan Cui, Xiaofeng Jiang, Jing Cao

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

The accumulation of plastic waste in the environment has raised widespread concern about impact microplastics (MPs) on human and environmental health, particularly regarding aged MPs. This study investigated effects subchronic dietary intake pristine polyethylene (PE-MPs) C57BL/6J mice. Results revealed that both PE-MPs, at doses 0.01 1 mg/day, induced plasma metabolic changes primarily associated with lipid metabolism digestive processes. These alterations were reflected expression proteins involved unsaturated fatty acid pathways liver as well a reduction beneficial gut microbiota. Key contributors toxicity PE-MPs included ATP-binding cassette transporters, bacteria (notably Lactobacillus, Akkermansia, Parasutterella, Turicibacter), significantly altered related to elongation, such acyl-CoA thioesterase enzyme family elongation very long chain protein 5. disruptions exacerbated disorders, potentially contributing diseases. Additionally, decreased levels glutathione S-transferase A proteins, along reduced hepatic increased reactive oxygen species small intestine liver, suggested aggravated intestinal damage through oxidative stress. findings indicated caused more severe dysfunction microbiota disruption. effect was likely mediated by transfer acids signaling molecules gut-liver axis, ultimately leading disorders

Language: Английский

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