Mechanistic Insights into 3-Isopropylphenol-Induced Neurotoxicity in Zebrafish: A Network Toxicology and Molecular Docking Approach DOI Creative Commons
Jie Gu,

Huilin Jin,

Jun Hu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 274 - 274

Published: April 3, 2025

Endocrine-disrupting chemicals (EDCs) are exogenous substances discharged into the environment through human activities. 3-Isopropylphenol, a typical alkylphenol-based EDC, has been extensively studied due to its broad application and potential ecological impacts. However, mechanism of neurotoxicity remains unclear. In this study, neurotoxic effects 3-isopropylphenol were examined using zebrafish model. We predicted toxic mechanisms action targets network toxicology molecular docking verified them via RT-qPCR. Results showed that exposure inhibits cAMP/PKA signaling pathway in larvae, promoting apoptosis, impairing neural development, suppressing locomotor behavior. These findings enhance our understanding on larval development aid evaluating hazards.

Language: Английский

Mechanistic Insights into 3-Isopropylphenol-Induced Neurotoxicity in Zebrafish: A Network Toxicology and Molecular Docking Approach DOI Creative Commons
Jie Gu,

Huilin Jin,

Jun Hu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 274 - 274

Published: April 3, 2025

Endocrine-disrupting chemicals (EDCs) are exogenous substances discharged into the environment through human activities. 3-Isopropylphenol, a typical alkylphenol-based EDC, has been extensively studied due to its broad application and potential ecological impacts. However, mechanism of neurotoxicity remains unclear. In this study, neurotoxic effects 3-isopropylphenol were examined using zebrafish model. We predicted toxic mechanisms action targets network toxicology molecular docking verified them via RT-qPCR. Results showed that exposure inhibits cAMP/PKA signaling pathway in larvae, promoting apoptosis, impairing neural development, suppressing locomotor behavior. These findings enhance our understanding on larval development aid evaluating hazards.

Language: Английский

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