Association of perfluoroalkyl substance (PFAS) on vitamin D biomarkers in a highly exposed population of the Veneto Region in Italy DOI Creative Commons
Andrea Di Nisio, Luca De Toni, Cristina Canova

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 374, P. 144230 - 144230

Published: Feb. 19, 2025

Perfluoroalkyl substances (PFASs) raise concerns about their environmental accumulation. Experimental data have suggested that PFASs interfere with bone metabolism from the early stages of life. However, mechanisms underlying this association are unclear. The aim study was to evaluate possible between exposure PFAS and vitamin D (VitD), serum calcium parathyroid hormone (PTH) levels in subjects residing high-exposure area Veneto Region Italy. In cross-sectional observational study, 1174 who previously adhered 2016-2018 Regional Surveillance Plan for plasma were recalled 2023 evaluated demographic, anthropometrics blood analyses. Data on nutritional habits VitD supplementation obtained by a dedicated questionnaire. Serum concentrations PFASs, calcium, 25-hydroxy-vitamin (25OH-VitD) PTH determined sampling. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS) perfluorohexanesulfonic (PFHxS) only three 12, quantifiable at least 90% samples considered further Generalized additive models, using linear regression smoothing thin plate splines, detected positive all (PFOA: β = 0.03; CI 95% 0.01-0.06; PFOS: 0.06; 0.02-0.09, PFHxS: 0.04; 0.01-0.06). Estimated degrees freedom (EDF) analysis showed approximately PFOA (EDF 1.89) PFHxS 1.21), but not PFOS 3.69). Differently, no either or PTH, except ln-transformed 25OH-D (β 0.00-0.08). Stratified analyses confirmed taking supplementation. Results show high may metabolism, independently lifestyle dietary factors. Further elucidation homeostasis disruption, including multiple binding-equilibrium albumin, remains be addressed.

Language: Английский

Association of perfluoroalkyl substance (PFAS) on vitamin D biomarkers in a highly exposed population of the Veneto Region in Italy DOI Creative Commons
Andrea Di Nisio, Luca De Toni, Cristina Canova

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 374, P. 144230 - 144230

Published: Feb. 19, 2025

Perfluoroalkyl substances (PFASs) raise concerns about their environmental accumulation. Experimental data have suggested that PFASs interfere with bone metabolism from the early stages of life. However, mechanisms underlying this association are unclear. The aim study was to evaluate possible between exposure PFAS and vitamin D (VitD), serum calcium parathyroid hormone (PTH) levels in subjects residing high-exposure area Veneto Region Italy. In cross-sectional observational study, 1174 who previously adhered 2016-2018 Regional Surveillance Plan for plasma were recalled 2023 evaluated demographic, anthropometrics blood analyses. Data on nutritional habits VitD supplementation obtained by a dedicated questionnaire. Serum concentrations PFASs, calcium, 25-hydroxy-vitamin (25OH-VitD) PTH determined sampling. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS) perfluorohexanesulfonic (PFHxS) only three 12, quantifiable at least 90% samples considered further Generalized additive models, using linear regression smoothing thin plate splines, detected positive all (PFOA: β = 0.03; CI 95% 0.01-0.06; PFOS: 0.06; 0.02-0.09, PFHxS: 0.04; 0.01-0.06). Estimated degrees freedom (EDF) analysis showed approximately PFOA (EDF 1.89) PFHxS 1.21), but not PFOS 3.69). Differently, no either or PTH, except ln-transformed 25OH-D (β 0.00-0.08). Stratified analyses confirmed taking supplementation. Results show high may metabolism, independently lifestyle dietary factors. Further elucidation homeostasis disruption, including multiple binding-equilibrium albumin, remains be addressed.

Language: Английский

Citations

0