Transformation products of antibiotics: overlooked drivers for enhancing the environmental spread of antibiotic resistance DOI Open Access

Yuan Zhang,

Jiayan Jiang, Mingbao Feng

et al.

Journal of Environmental Exposure Assessment, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 10, 2025

Humans have released thousands of antibiotics into the environment, which is a primary driver global dissemination bacterial resistance. Parent compounds can generate various transformation products (TPs), many remain unidentified and lack comprehensive microbial risk assessments. The TPs formed during process may exhibit structural similarities to parent compounds, they induce antibiotic-like resistance transmission despite lacking bactericidal/antibacterial properties compounds. However, assessments antimicrobial hazards predominantly emphasize while largely neglecting their TPs. Here, we highlight that warrant greater attention regarding chemical structure identification transmission. This perspective summarizes TPs’ potential, mechanisms, challenges in triggering

Language: Английский

Transformation products of antibiotics: overlooked drivers for enhancing the environmental spread of antibiotic resistance DOI Open Access

Yuan Zhang,

Jiayan Jiang, Mingbao Feng

et al.

Journal of Environmental Exposure Assessment, Journal Year: 2025, Volume and Issue: 4(2)

Published: April 10, 2025

Humans have released thousands of antibiotics into the environment, which is a primary driver global dissemination bacterial resistance. Parent compounds can generate various transformation products (TPs), many remain unidentified and lack comprehensive microbial risk assessments. The TPs formed during process may exhibit structural similarities to parent compounds, they induce antibiotic-like resistance transmission despite lacking bactericidal/antibacterial properties compounds. However, assessments antimicrobial hazards predominantly emphasize while largely neglecting their TPs. Here, we highlight that warrant greater attention regarding chemical structure identification transmission. This perspective summarizes TPs’ potential, mechanisms, challenges in triggering

Language: Английский

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