Green Synthesis of Novel Triazolothiadiazine‐Coumarins Catalyzed by Agro Waste Extract: An Approach towards In‐Silico and In‐Vitro Anti‐Fungal Activity

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(13)

Published: April 4, 2022

Abstract A green, commodious, immensely versatile synthetic route for agro waste extract WELPSA catalyzed cyclocondensation of biologically active triazolothiadiazine‐coumarin hybrid derivatives has been studied. proficient synthesis offused heterocycles 9 i – w via dehydrative condensation with cyclization of4‐((4‐amino‐5‐mercapto‐4 H ‐1,2,4‐triazol‐3‐yl)methyl)‐2‐aryl‐2,4‐dihydro‐3 ‐1,2,4‐triazol‐3‐one ( 5 a ‐ ‐c ) and substituted bromoacyl coumarins 8 d ‐h )has incorporated in presence different catalysts including WELPSA, green catalyst. The silico docking studies these previously unknown compounds revealed favorable C score Chemscore values the vitro antifungal assay against three fungal strains showed excellent to good activity.

Language: Английский

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Recent Approaches in the Synthesis of 5-Arylidene-2,4-thiazolidinedione Derivatives Using Knoevenagel Condensation

Mini-Reviews in Organic Chemistry, Journal Year: 2022, Volume and Issue: 20(1), P. 5 - 34

Published: April 1, 2022

Abstract: 5-Arylidene-2,4-thiazolidinedione (5-A-TZD) is an emerging precursor molecule in medicinal chemistry for discovering multifunctional therapeutic agents. For synthesizing this molecule, Knoevenagel Condensation (KC) one of the most excellent tools modern organic chemistry. The 5-A-TZD framework has a variety functions such as antidiabetic, anticancer, antimicrobial, and anti-inflammatory. As result, several approaches methods KC have been established synthesis precursor. However, use highly corrosive catalysts, prolonged reaction times, by-products formation, poor product yields are main drawbacks 5-A-TZDs via KC. Therefore, authors successfully fast, effective, environmentally sustainable protocols using inorganic heterogeneous solid ionic liquids (ILs), bio-catalysts to synthesize derivatives with high conversion yield selectivity. In review, we summarized recent their application

Language: Английский

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Water hyacinth ash: an efficient green catalyst for the synthesis of β-amino carbonyl/nitrile compounds by aza-Michael reaction at room temperature

SN Applied Sciences, Journal Year: 2020, Volume and Issue: 2(4)

Published: March 10, 2020

Language: Английский

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Synthesis, Antioxidant, and Electrochemical Behavior Studies of 2-Amino-4 H -Chromene Derivatives Catalyzed by WEOFPA: Green Protocol

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(1), P. 333 - 360

Published: Feb. 10, 2023

In this work, we have described an efficient one-pot three-component preparation of 2-amino-4H-chromene by the reaction aromatic aldehyde (1), malononitrile, or ethylcyanoacetate (2), and α ꞵ-naphthol resorcinol (3) in presence catalyst Water Extract Orange Fruit Peel Ash agro-waste extracted solvent medium (4 mL) with few drops ethanol as co-solvent accelerated microwave irradiation. The is optimized various methods such magnetic stirring, mechanochemical, ultrasound, irradiation, but irradiation 180 W power gave excelled yield faster rate product isolation (4–5 min). method developed found eco-friendly, metal-free, chemical-less, solvent-less, inexpensive, facile approach for synthesis derivatives. final isolated recrystallized ethanol, characterized FT-IR, 1H-, 13C-NMR LC-MS spectrometry techniques. Some selected chromene derivatives are subjected to antioxidant activity concentration range 200–1,000 µg/µL 2,2-diphenyl-1-picrylhydrazyl method. 4a, 4 g, 4h, 6a, 6b, 6c, 8a, 8f showed activities were comparable standard ascorbic acid used. Further, studies on electrochemical behavior (4e, 4f, 4i, 6f, 8d, 8f) cyclic voltammetry technique 50 mVs−1, revealed that, some these molecules good oxidation reduction potential.

Language: Английский

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A green protocol for one-pot synthesis of 3,4-dihydropyrano[c]chromenes and biscoumarins by employing WEB as an internal base

Results in Chemistry, Journal Year: 2022, Volume and Issue: 4, P. 100589 - 100589

Published: Jan. 1, 2022

A simple, mild and environmentally benign methodology has been developed for the synthesis of 3,4-dihydropyrano[c]chromenes biscoumarins using water extract banana peel ash (WEB) as a natural base under ultrasound (US) irradiation. Interestingly, addition ethanol co-solvent improved yield desired products. This agro-waste based protocol simple workup procedure column-free purification with no need external to facilitate reaction.

Language: Английский

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Organocatalytic Synthesis of (Hetero)arylidene Malononitriles Using a More Sustainable, Greener, and Scalable Strategy

Current Organic Synthesis, Journal Year: 2024, Volume and Issue: 21(5), P. 704 - 716

Published: Jan. 13, 2024

The establishment of a green and sustainable Knoevenagel condensation reaction in organic chemistry is still crucial. This work aimed to provide newly developed metal-free halogen-free catalytic methodology for the synthesis CS (hetero-) arylidene malononitriles laboratory industrial scale. various carbonyl groups with malononitrile was investigated ethanol, an ecofriendly medium, presence seven nitrogen-based organocatalysts.

Language: Английский

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An Agro‐Waste Based Eco‐Friendly Synthesis, Electrochemical Behavior and Anti‐oxidant Properties Evaluation of Pyrano[2,3‐c]pyrazole and Pyrazolyl‐4H‐chromenes Derivatives

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(9)

Published: March 4, 2022

Abstract An efficient and economical one‐pot synthesis of pyrano[2,3‐ c ] pyrazoles pyrazolyl‐4 H ‐chromenes using Water Extract Mango Peel Ash (WEMPA) as a natural aqueous medium catalysts under microwave irradiation described. The enhances the rate reaction, decreases by‐product formation. catalyst is obtained from agro‐waste feedstock, by simple thermal treatment dry peel mango fruit followed extraction resulted ash in water gave catalytic green solvent medium. In continuation our research work on developing chemistry protocol for bioactive molecule synthesis, herein, first time described ]pyrazole ‐chromene derivative reaction hydrazine hydrate ( 1 ), malononitrile 2 ethyl acetoacetate 3 aryl aldehydes 4 and/or salicylaldehyde 5 ). Some selected 6 ) 7 derivatives are tested their vitro antioxidant activity (free radical scavenging) DPPH assay method. result revealed, compounds , h i d showed significant activities comparison with refrence ascorbic acid. characterized FT‐IR, H‐, 13 C‐NMR mass spectrometry analysis, also electrochemical behavior studies cyclic voltammetry.

Language: Английский

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Mechanism study and preparing (hetero)arylidene malononitriles through a greener and scalable catalytic strategy

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1302, P. 137422 - 137422

Published: Dec. 27, 2023

Language: Английский

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Generation of new carbon–carbon and carbon–heteroatom bonds mediated by agro-waste extracts: a review

Environmental Chemistry Letters, Journal Year: 2021, Volume and Issue: 20(1), P. 841 - 873

Published: Oct. 30, 2021

Language: Английский

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Agro-Waste Sourced Catalyst as an Eco-Friendly and Sustainable Approach for Knoevenagel Condensation Reaction

Current Organocatalysis, Journal Year: 2021, Volume and Issue: 9(2), P. 179 - 194

Published: Dec. 24, 2021

Background: The present work describes an eco-friendly and sustainable approach for the Knoevenagel condensation of aromatic aldehyde with ethyl cyanoacetate, salicylaldehyde Meldrum acid synthesis benzylidenecyanoacetate 3-carboxy coumarin (2-oxo-2H-1-benzopyran) derivatives, respectively. reaction was performed under green catalytic media-Water Extract Watermelon Fruit Peel Ash (WEWFPA), which is protocol derived from agro-waste feedstock. Various protocols have been reported using a hazardous catalyst or/and solvents found toxic to environment, requiring longer time, giving poor yield, purification final product. method at hand provides several added advantages like: being completely method, economic, inexpensive catalyst, product isolated in pure form good yield. Objective: objective study develop methodology derivatives. Results: based developed avoids use external inorganic/ organic bases additives. derivatives carried out room temperature microwave irradiation, solvent-free synthesis, less time better Methods: We demonstrated that WEWFPA can be employed as homogenous agrowaste rt stirring irradiation very economical way. simple robust, non-hazardous obtain target Conclusion: In conclusion, we established efficient, simple, ethylbenzylidenecyanoacetate employing efficient synthesis. green, products. are no metal chemical base free, short excellent yield derived, abundant nature, thus making greener one.

Language: Английский

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