Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles DOI Creative Commons

Rongkang Zhang,

Liliang Huang,

Aiguo Gu

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(1), P. 19 - 19

Published: Feb. 4, 2025

3-Oxetanone-derived spirooxazolidines represent a class of building blocks for accessing diverse saturated heterocycles, but their synthetic methods remain unexplored. Herein, we demonstrate highly atom-economic approach the synthesis 3-oxetanone-derived N-propargyl via CuBr2/TFA co-catalyzed four-component A3-based cascade reaction 1,2-amino alcohol, 3-oxetanone, formaldehyde, and an alkyne. This strategy is characterized by wide substrate range excellent chemoselectivity. In addition, synthesized spirocycles could also be easily converted into other valuable compounds, facilitating potentially useful applications.

Language: Английский

Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles DOI Creative Commons

Rongkang Zhang,

Liliang Huang,

Aiguo Gu

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(1), P. 19 - 19

Published: Feb. 4, 2025

3-Oxetanone-derived spirooxazolidines represent a class of building blocks for accessing diverse saturated heterocycles, but their synthetic methods remain unexplored. Herein, we demonstrate highly atom-economic approach the synthesis 3-oxetanone-derived N-propargyl via CuBr2/TFA co-catalyzed four-component A3-based cascade reaction 1,2-amino alcohol, 3-oxetanone, formaldehyde, and an alkyne. This strategy is characterized by wide substrate range excellent chemoselectivity. In addition, synthesized spirocycles could also be easily converted into other valuable compounds, facilitating potentially useful applications.

Language: Английский

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