Long COVID: A Molecular, Cellular and Histopathology Overview DOI Open Access
Bárbara Rafaela da Silva Barros,

Leonardo Carvalho de Oliveira Cruz,

Georon Ferreira de Sousa

et al.

Journal of Biosciences and Medicines, Journal Year: 2023, Volume and Issue: 11(09), P. 90 - 113

Published: Jan. 1, 2023

Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of disease. Persistent symptoms such dry cough, fatigue, and dyspnea remain six months COVID-19 cure. Others lung fibrosis, kidney injury, thrombotic risk also are observed. Here, a deep review each human organ system infected by virus was performed aiming to show how molecules expression cell signaling induce organism cure or injuries and, subsequently sequelae. The suggests importance public health surveillance for these cases including more comprehensive analysis molecular biology tools clarify assist in prognosis, treatment, preventive methods potentially serious disorders post-COVID-19 patients.

Language: Английский

Research Advances in Detection of Myocardial Infarction DOI

娟 卢

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 2232 - 2239

Published: Jan. 1, 2025

Language: Английский

Citations

0

The impact of stress and anesthesia on animal models of infectious disease DOI Creative Commons
Rachel Layton, Daniel Layton,

David Beggs

et al.

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 2, 2023

Stress and general anesthesia have an impact on the functional response of organism due to detrimental effects cardiovascular, immunological, metabolic function, which could limit organism's infectious event. Animal studies formed essential step in understanding mitigating diseases, as complexities physiology immunity cannot yet be replicated vivo . Using animals research continues come under increasing societal scrutiny, it is therefore crucial that welfare used disease optimized meet both expectations improve scientific outcomes. Everyday management procedures animal are known cause stress, can not only poorer outcomes, but also introduces variables studies. Whilst necessary at times reduce stress enhance research, evidence physiological immunological disruption caused by increasing. To better understand quantify study utilizing most appropriate monitoring strategies imperative. This article aims analyze recent about uncontrolled variables, well reviewing technologies models during diseases.

Language: Английский

Citations

9

The SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications DOI Creative Commons

Priya Veluswamy,

Max Wacker, Dimitrios Stavridis

et al.

Viruses, Journal Year: 2021, Volume and Issue: 13(7), P. 1346 - 1346

Published: July 12, 2021

The SARS-CoV-2 virus causing COVID-19 disease has emerged expeditiously in the world and been declared pandemic since March 2020, by World Health Organization (WHO). destructive effects of infection are increased among patients with pre-existing chronic conditions and, particular, this review focuses on underlying cardiovascular complications. expression pattern potential functions binding receptors attributes tropism a physio-pathological state heart blood vessel precisely described. Of note, atheroprotective role ACE2 is reviewed. A detailed description possible detrimental terms vascular leakage, including endothelial glycocalyx dysfunction bradykinin 1 receptor stimulation concisely stated. Furthermore, molecular mechanisms induced clot formation association host defense components, activation FXIIa, complements platelets, dysfunction, immune cell responses cytokine-mediated action well elaborated. Moreover, brief clinical update patient complications those who had new onset post-COVID-19 was also discussed. Taken together, provides an overview mechanistic aspects devastating effects, vital organs such as vessels.

Language: Английский

Citations

15

Elevated serum midkine levels in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients DOI Open Access
Sema Ketenci, M. Uygar Kalaycı, Bağnu Dündar

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 110, P. 108939 - 108939

Published: June 9, 2022

Language: Английский

Citations

7

Lymphangiogenesis: A new strategy for heart disease treatment (Review) DOI Creative Commons

Liding Bai,

Yanyan Wang,

Siqi Du

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(4)

Published: Feb. 22, 2024

Heart disease remains a global health challenge, contributing notably to morbidity and mortality. The lymphatic vasculature, an integral component of the cardiovascular system, plays crucial role in regulating essential physiological processes, including fluid balance, transportation extravasated proteins immune cell trafficking, all which are important for heart function. Through thorough scientometric analysis extensive research, present review identified lymphangiogenesis as hotspot mechanisms underlying impaired cardiac inadequate lymph drainage various diseases discussed. Furthermore, way used improve effectively regulate variety associated signaling pathways was investigated. Notably, current also highlights impact Traditional Chinese Medicine (TCM) on lymphangiogenesis, aiming establish clinical basis potential TCM by promoting lymphangiogenesis.

Language: Английский

Citations

1

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage DOI Creative Commons
Arutha Kulasinghe, Ning Liu, Chin Wee Tan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: March 31, 2022

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison the 2009 pandemic (pH1N1), SARS-CoV-2 infection likely lead more disease, multi-organ effects, including cardiovascular disease. has been associated long-term but molecular changes govern this remain unknown. study, we investigated landscape of cardiac tissues collected at rapid autopsy from SARS-CoV-2, pH1N1, control patients using targeted spatial transcriptomics approaches. Although was not detected in tissue, host showed upregulation genes DNA damage repair, heat shock, M1-like macrophage infiltration COVID-19 patients. patient samples, were further confirmed by γ−H2Ax immunohistochemistry. comparison, pH1N1 Interferon-stimulated (ISGs), particular interferon complement pathways, when compared These data demonstrate emergence distinct transcriptomic profiles influenza supporting need for a greater understanding effects on organs, system patients, delineate immunopathobiology infection, long term impact health.

Language: Английский

Citations

4

COVID-19 Presenting as Recurrent Pericardial Effusion DOI Open Access
Dena H. Tran, Anuj Gupta, Avelino C. Verceles

et al.

Cureus, Journal Year: 2021, Volume and Issue: unknown

Published: Oct. 11, 2021

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) emerged from Wuhan, China, in 2019, causing disease 19 (COVID-19) and creating a global pandemic affecting millions of people worldwide. Though COVID-19 primarily affects the pulmonary structures, deleterious effects can also occur cardiac system. We present case patient with recurrent pericardial effusions secondary to infection, an unusual cardiovascular manifestation this disease. A 47-year-old man presented altered mental status tested positive for COVID-19. He left against medical advice later two weeks pleuritic chest pain associated shortness breath. His symptoms were attributed moderate- large-sized effusion, without evidence tamponade, as confirmed by echocardiography. The fluid was removed pericardiocentesis; analysis negative malignant cells, inflammatory markers, or microbiologic studies. Reaccumulation necessitated placement window, resulting resolution his symptoms. There are limited reports demonstrating association effusion infection. is likely response leading capillary leakage, traversing serous pericardium. In addition other demonstrated effects, appears be effusion. Due rise cases, it essential consider rare but potential complication virus. primary clinical manifestation, nature, potentially result tamponade physiology.

Language: Английский

Citations

4

Efecto del ejercicio aeróbico sobre la capacidad cardiorrespiratoria en pacientes sobrevivientes de covid-19: metaanálisis DOI Creative Commons
Hibsen Alonso Jiménez-Rodríguez,

Gerardo Araya Araya

Pensar en Movimiento Revista de Ciencias del Ejercicio y la Salud, Journal Year: 2023, Volume and Issue: 21(1), P. e53531 - e53531

Published: April 28, 2023

El propósito del estudio fue cuantificar el tamaño de efecto (TE) ejercicio aeróbico sobre la capacidad cardiorrespiratoria en sobrevivientes enfermedad COVID-19, producida por virus SARS-CoV 2. Se revisaron dos bases datos (EBSCO host y PubMed) entre los meses agosto a noviembre año 2021. encontraron 142,656 posibles artículos luego varios filtros, se incluyeron 9 estudios que cumplían requisitos inclusión. usó modelo efectos aleatorios. obtuvieron 12 TE un primer metaanálisis tuvo sesgo (según prueba Egger). Tras identificar eliminar grupos con extremo, obtuvo corregido sin 7 TE, donde encontró tiene significativo, positivo magnitud grande, condición COVID-19 (TE=0.849; IC95%: 0.715 - 0.982; Q=7.13; p=0.522; I2=0.87%; Egger p=0.205). Las intervenciones favorecen mejora cardiorrespiratoria, pacientes COVID-19. Dos aplicaron solo aeróbico, mientras otros siete, combinaban fuerza otras modalidades. En todos casos significativo. Finalmente, estos resultados fueron relativamente homogéneos, evidenciar influencia variables moderadoras.

Citations

1

COVID-19-Associated Nephropathy: A Devastating Complication DOI Open Access
Andrew Kim, Abdullahi Mahgoub,

Abinash Parajuli

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

With the rapid emergence and prevalence of SARS-CoV-2 worldwide, cases COVID-19-associated nephropathy (COVAN) from collapsing focal segmental glomerulosclerosis (cFSGS) have been reported, associations between two are actively being studied. Creating appropriate treatment guidelines for COVAN requires further understanding pathophysiology this type kidney injury. This case report outlines a 77-year-old patient admitted to hospital COVID-19 infection with subsequent renal biopsy indicating cFSGS, adding data exploring relationship infections, cFSGS associated risk factors. Current on similar those other causes but continue poor outcomes resistance treatments. Further research needs be done both clinical assessment provide timely life-saving interventions.

Language: Английский

Citations

1

From cardiovascular system to brain, the potential protective role of Mas Receptors in COVID-19 infection DOI
Pamela Cappelletti, Giovanna Gallo,

Rachele Marino

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 959, P. 176061 - 176061

Published: Sept. 27, 2023

Language: Английский

Citations

1