Transient Global Amnesia (TGA): Is It Really Benign? A Pilot Study on Blood Biomarkers DOI Open Access

Fabio Rossini,

Tobias Moser,

Michael Unterhofer

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2629 - 2629

Published: March 14, 2025

We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers—serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24–48 h onset (t0) 6 weeks thereafter (t1). assessed sNfL sGFAP levels using the highly sensitive single-molecule array assay calculated Z-scores adjusted for age, gender, body mass index (BMI). Demographics, electroencephalography (EEG), cerebral magnetic resonance imaging (cMRI) findings also collected. A total 20 patients included (median age: 66 years, 70% women). No significant changes or at t0 t1 observed. Median 0.45 (interquartile range [IQR] −0.09, 1.19) 0.60 (IQR −0.61, t1. 0.27 −0.45, 0.76) 0.44 −0.27, 0.75) Similarly, subgroup diffusion-weighted (DWI)-positive hippocampal lesions (n = 5/20[25%]), no elevations biomarkers detected. Our pilot study on neurological supports benign nature TGA, indicating that CNS tissue damage occurs.

Language: Английский

Transient Global Amnesia (TGA): Is It Really Benign? A Pilot Study on Blood Biomarkers DOI Open Access

Fabio Rossini,

Tobias Moser,

Michael Unterhofer

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2629 - 2629

Published: March 14, 2025

We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers—serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24–48 h onset (t0) 6 weeks thereafter (t1). assessed sNfL sGFAP levels using the highly sensitive single-molecule array assay calculated Z-scores adjusted for age, gender, body mass index (BMI). Demographics, electroencephalography (EEG), cerebral magnetic resonance imaging (cMRI) findings also collected. A total 20 patients included (median age: 66 years, 70% women). No significant changes or at t0 t1 observed. Median 0.45 (interquartile range [IQR] −0.09, 1.19) 0.60 (IQR −0.61, t1. 0.27 −0.45, 0.76) 0.44 −0.27, 0.75) Similarly, subgroup diffusion-weighted (DWI)-positive hippocampal lesions (n = 5/20[25%]), no elevations biomarkers detected. Our pilot study on neurological supports benign nature TGA, indicating that CNS tissue damage occurs.

Language: Английский

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