Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Oxygen‐free
radicals,
reactive
oxygen
species
(ROS)
or
nitrogen
(RNS),
are
known
by
their
“double‐sided”
nature
in
biological
systems.
The
beneficial
effects
of
ROS
involve
physiological
roles
as
weapons
the
arsenal
immune
system
(destroying
bacteria
within
phagocytic
cells)
and
role
programmed
cell
death
(apoptosis).
On
other
hand,
redox
imbalance
favor
prooxidants
results
an
overproduction
ROS/RNS
leading
to
oxidative
stress.
This
can,
therefore,
be
related
oncogenic
stimulation.
High
levels
disrupt
cellular
processes
nonspecifically
attacking
proteins,
lipids,
DNA.
It
appears
that
DNA
damage
is
key
player
cancer
initiation
formation
8‐OH‐G,
a
potential
biomarker
for
carcinogenesis.
harmful
effect
neutralized
antioxidant
protection
treatment
they
convert
into
less
species.
However,
contradictory
epidemiological
show
supplementation
above
doses
recommended
antioxidants
taken
over
long
period
can
lead
even
increase
risk
cancer.
Thus,
we
describing
here
some
latest
updates
on
involvement
stress
pathology
double
view
this
context
how
could
relevant
management
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(7), P. 1102 - 1102
Published: March 27, 2022
Nanoparticles
are
currently
used
for
cancer
theranostics
in
the
clinical
field.
Among
nanoparticles,
gold
nanoparticles
(AuNPs)
attract
much
attention
due
to
their
usability
and
high
performance
imaging
techniques.
The
wide
availability
of
biological
precursors
plant-based
synthesized
AuNPs
allows
development
large-scale
production
a
greener
manner.
Conventional
therapies,
such
as
surgery
chemotherapy,
have
significant
limitations
frequently
fail
produce
satisfying
results.
prolonged
circulation
time,
allow
easy
modification
with
ligands
detected
via
cell
surface
receptors,
increase
uptake
through
receptor-mediated
endocytosis.
To
exploit
these
unique
features,
studies
been
carried
out
on
use
contrast
agents
X-ray-based
techniques
(i.e.,
computed
tomography).
As
nanocarriers,
by
nontoxic
biocompatible
plants
deliver
therapeutic
biomolecules
could
be
stride
forward
effective
treatment
various
cancers.
Fluorescent-plant-based
markers,
including
AuNPs,
fabricated
using
Medicago
sativa,
Olax
Scandens,
H.
ambavilla,
lanceolatum,
detecting
Moreover,
green
extracts
applied
different
types
solid
tumors.
However,
cytotoxicity
primarily
depends
size,
reactivity,
area.
In
this
review,
benefits
materials
therapy
firstly
explained.
Then,
considering
valuable
position
medicine,
application
detection
is
highlighted
an
emphasis
faced
NPs
drug
delivery
platforms.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2022,
Volume and Issue:
41(1)
Published: July 1, 2022
Abstract
Background
One
of
the
most
malignant
tumors
in
men
is
prostate
cancer
that
still
incurable
due
to
its
heterogenous
and
progressive
natures.
Genetic
epigenetic
changes
play
significant
roles
development.
The
RNA
molecules
with
more
than
200
nucleotides
length
are
known
as
lncRNAs
these
factors
do
not
encode
protein.
They
regulate
gene
expression
at
transcriptional,
post-transcriptional
levels.
LncRNAs
vital
biological
functions
cells
pathological
events,
hence
their
undergoes
dysregulation.
Aim
review
role
alterations
development
emphasized
here.
Therefore,
were
chosen
for
this
purpose
level
interaction
other
signaling
networks
progression
examined.
Key
scientific
concepts
aberrant
has
been
well-documented
rate
tumor
regulated
via
affecting
STAT3,
NF-κB,
Wnt,
PI3K/Akt
PTEN,
among
molecular
pathways.
Furthermore,
radio-resistance
chemo-resistance
features
cells.
Overexpression
tumor-promoting
such
HOXD-AS1
CCAT1
can
result
drug
resistance.
Besides,
induce
immune
evasion
upregulating
PD-1.
Pharmacological
compounds
quercetin
curcumin
have
applied
targeting
lncRNAs.
siRNA
tool
reduce
thereby
suppressing
progression.
Prognosis
diagnosis
clinical
course
be
evaluated
by
exosomal
lncRNA-p21
investigated
serum
patients
a
reliable
biomarker.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(7), P. 2029 - 2029
Published: April 2, 2021
Flavonoids
represent
an
important
group
of
bioactive
compounds
derived
from
plant-based
foods
and
beverages
with
known
biological
activity
in
cells.
From
the
modulation
inflammation
to
inhibition
cell
proliferation,
flavonoids
have
been
described
as
therapeutic
adjuvants
against
several
diseases,
including
diabetes,
arteriosclerosis,
neurological
disorders,
cancer.
Cancer
is
a
complex
multifactor
disease
that
has
studied
for
years
however,
its
prevention
still
one
best
efficient
factors
impacting
epidemiology
disease.
In
molecular
cellular
context,
some
mechanisms
underlying
oncogenesis
progression
are
understood,
hallmarks
this
text,
we
review
signaling
pathways,
inflammation,
immunity,
redox
metabolism,
growth,
autophagy,
apoptosis,
cycle,
analyze
action
The
current
literature
provides
enough
evidence
supporting
may
be
cancer
therapy,
highlighting
importance
healthy
balanced
diets
prevent
onset
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2022,
Volume and Issue:
41(1)
Published: March 22, 2022
Abstract
Prostate
cancer
is
a
leading
cause
of
death
worldwide
and
new
estimates
revealed
prostate
as
the
in
men
2021.
Therefore,
strategies
are
pertinent
treatment
this
malignant
disease.
Macroautophagy/autophagy
“self-degradation”
mechanism
capable
facilitating
turnover
long-lived
toxic
macromolecules
organelles.
Recently,
attention
has
been
drawn
towards
role
autophagy
how
its
modulation
provides
effective
therapy.
In
present
review,
we
provide
mechanistic
discussion
cancer.
Autophagy
can
promote/inhibit
proliferation
survival
cells.
Besides,
metastasis
cells
affected
(via
induction
inhibition)
by
autophagy.
affect
response
to
therapy
such
chemotherapy
radiotherapy,
given
close
association
between
apoptosis.
Increasing
evidence
demonstrated
that
upstream
mediators
AMPK,
non-coding
RNAs,
KLF5,
MTOR
others
regulate
Anti-tumor
compounds,
for
instance
phytochemicals,
dually
inhibit
or
induce
For
improving
therapy,
nanotherapeutics
chitosan
nanoparticles
have
developed.
With
respect
context-dependent
cancer,
genetic
tools
siRNA
CRISPR-Cas9
be
utilized
targeting
autophagic
genes.
Finally,
these
findings
translated
into
preclinical
clinical
studies
improve
prognosis
patients.
Graphical
abstract
Phytotherapy Research,
Journal Year:
2021,
Volume and Issue:
36(1), P. 299 - 322
Published: Nov. 3, 2021
Phytosterols
(PSs),
classified
into
plant
sterols
and
stanols,
are
bioactive
compounds
found
in
foods
of
origin.
PSs
have
been
proposed
to
exert
a
wide
number
pharmacological
properties,
including
the
potential
reduce
total
low‐density
lipoprotein
(LDL)
cholesterol
levels
thereby
decreasing
risk
cardiovascular
diseases.
Other
health‐promoting
effects
include
anti‐obesity,
anti‐diabetic,
anti‐microbial,
anti‐inflammatory,
immunomodulatory
effects.
Also,
anticancer
strongly
suggested,
as
phytosterol‐rich
diets
may
cancer
by
20%.
The
aim
this
review
is
provide
general
overview
available
evidence
regarding
beneficial
physiological
activities
PSs,
with
special
emphasis
on
their
therapeutic
for
human
health
safety.
we
will
explore
factors
that
influence
physiologic
response
PSs.
Journal of Hematology & Oncology,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: July 14, 2023
Early
detection
and
diagnosis
of
many
cancers
is
very
challenging.
Late
stage
a
cancer
always
leads
to
high
mortality
rates.
It
imperative
develop
novel
more
sensitive
effective
therapeutic
methods
for
treatments.
The
development
new
treatments
has
become
crucial
aspect
medical
advancements.
Nanobots,
as
one
the
most
promising
applications
nanomedicines,
are
at
forefront
multidisciplinary
research.
With
progress
nanotechnology,
nanobots
enable
assembly
deployment
functional
molecular/nanosized
machines
increasingly
being
utilized
in
treatment.
In
recent
years,
various
practical
have
transitioned
from
theory
practice,
vitro
experiments
vivo
applications.
this
paper,
we
review
analyze
advancements
treatments,
with
particular
emphasis
on
their
key
fundamental
features
drug
delivery,
tumor
sensing
diagnosis,
targeted
therapy,
minimally
invasive
surgery,
other
comprehensive
At
same
time,
discuss
challenges
potential
research
opportunities
revolutionizing
future,
expected
sophisticated
capable
performing
multiple
functions
tasks,
ultimately
becoming
true
nanosubmarines
bloodstream.
Drug Development Research,
Journal Year:
2023,
Volume and Issue:
84(4), P. 718 - 735
Published: March 29, 2023
Abstract
This
study
aimed
to
design
and
synthesize
active
hybrids
of
β
‐elemene
nitric
oxide
(NO)
donor
pharmacophore
as
potential
agents
for
treating
leukemia.
Derivatives
reported
herein
exerted
better
inhibitory
effects
against
human
chronic
myeloid
leukemia
K562
cells
compared
(IC
50
>
100
μM).
The
most
potent
compound
18f
showed
an
IC
value
0.53
μM
cells,
well
a
high
NO
release
level
in
vitro.
In
the
xenograft
tumor
mice
model,
effectively
inhibited
growth
tumor,
with
significant
inhibition
rate
73.18%.
After
treatment
,
body
weight
did
not
decrease,
indicating
that
it
possessed
good
safety
profile.
All
these
proved
was
excellent
agent
