Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: June 13, 2023
The
epithelial-to-mesenchymal
transition
(EMT)
is
a
trans-differentiation
process
that
endows
epithelial
cells
with
mesenchymal
properties,
including
motility
and
invasion
capacity;
therefore,
its
aberrant
reactivation
in
cancerous
represents
critical
step
to
gain
metastatic
phenotype.
EMT
dynamic
program
of
cell
plasticity;
many
partial
states
can
be,
indeed,
encountered
the
full
inverse
mesenchymal-to-epithelial
(MET)
appears
fundamental
colonize
distant
secondary
sites.
EMT/MET
dynamics
granted
by
fine
modulation
gene
expression
response
intrinsic
extrinsic
signals.
In
this
complex
scenario,
long
non-coding
RNAs
(lncRNAs)
emerged
as
players.
This
review
specifically
focuses
on
lncRNA
HOTAIR,
master
regulator
plasticity
tumors.
Molecular
mechanisms
controlling
differentiated
well
trans-differentiated
are
highlighted
here.
Moreover,
current
knowledge
about
HOTAIR
pleiotropic
functions
regulation
both
protein
activities
described.
Furthermore,
relevance
specific
targeting
challenges
exploiting
for
therapeutic
approaches
counteract
discussed.
Journal of Cellular and Molecular Medicine,
Journal Year:
2022,
Volume and Issue:
26(5), P. 1363 - 1379
Published: Jan. 23, 2022
Abstract
Pre‐B‐cell
leukaemia
transcription
factor
(PBX)
proteins
are
a
subfamily
of
evolutionarily
conserved,
atypical
homeodomain
factors
that
belong
to
the
superfamily
three
amino
acid
loop
extension
(TALE)
proteins.
Members
PBX
family
play
crucial
roles
in
regulating
multiple
pathophysiological
processes,
such
as
development
organs,
congenital
cardiac
defects
and
carcinogenesis.
The
dysregulation
PBXs
has
been
shown
be
closely
associated
with
many
diseases,
particularly
cancer.
However,
detailed
mechanisms
cancer
progression
still
inconclusive.
In
this
review,
we
summarize
recent
advances
structures,
functions
regulatory
PBXs,
discuss
their
underlying
progression.
We
also
highlight
great
potential
biomarkers
for
early
diagnosis
prognostic
evaluation
well
therapeutic
applications.
information
reviewed
here
may
expand
researchers’
understanding
could
strengthen
clinical
implication
treatment.
Cells,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1149 - 1149
Published: March 29, 2022
Cervical
cancer
is
one
of
the
leading
causes
death
in
gynecology
worldwide.
High-risk
human
papillomaviruses
(HPVs)
are
major
etiological
agents
for
cervical
cancer.
Still,
other
factors
also
contribute
to
development
because
these
cancers
commonly
arise
decades
after
initial
exposure
HPV.
So
far,
molecular
mechanisms
underlying
pathogenesis
still
quite
limited,
and
a
knowledge
gap
needs
be
filled
help
develop
novel
strategies
that
will
ultimately
facilitate
therapies
improve
patient
outcomes.
Long
non-coding
RNAs
(lncRNAs)
have
been
increasingly
shown
involved
gene
regulation,
relevant
role
lncRNAs
has
recently
investigated.
In
this
review,
we
summarize
recent
progress
ascertaining
biological
functions
from
perspective
proliferation,
invasion,
metastasis.
addition,
provide
current
state
by
discussing
regulation
emerging
Comprehensive
deeper
insights
into
lncRNA-mediated
alterations
interactions
cellular
events
treat
patients
with
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115488 - 115488
Published: Sept. 18, 2023
Osteoarthritis
(OA)
is
an
extremely
common
type
of
chronic
progressive
disease
in
clinical
practice.
lncRNA
TUC339
has
a
close
association
with
bone
marrow
mesenchymal
stem
cell
(BMSC)
and
important
impact
on
organismal
inflammation.
However,
the
mechanism
BMSC-derived
OA
was
poorly
understood.
In
this
study,
we
found
that
lower
research
group
than
control
it
negatively
correlated
IL-6,
IL-8
TNF-α.
Prognosis
patients
recurrent
those
without
recurrence,
ROC
analysis
manifested
had
better
predictive
value
for
recurrence
OA.
Phenotypic
identification
revealed
elevated
expression
CD29
CD44
BMSCs
TSG101,
CD63
CD81
BMSCs-exosome
(BMSCs-exo),
versus
exosome
phenotype.
Finally,
animal
experiments
improved
significantly
joint
injury
BMSCs-exo
TUC339-overexpression
vector
groups
compared
groups.
Similarly,
activity
chondrocytes
enhanced,
apoptosis
reduced
rats.
Study
demonstrated
improves
by
elevating
to
promote
M1-type
mø
M2-type
polarization,
suppressing
inflammation
promoting
chondrocyte
activity,
which
provides
reliable
basis
future
transplantation
therapy
MSCs
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: June 13, 2023
The
epithelial-to-mesenchymal
transition
(EMT)
is
a
trans-differentiation
process
that
endows
epithelial
cells
with
mesenchymal
properties,
including
motility
and
invasion
capacity;
therefore,
its
aberrant
reactivation
in
cancerous
represents
critical
step
to
gain
metastatic
phenotype.
EMT
dynamic
program
of
cell
plasticity;
many
partial
states
can
be,
indeed,
encountered
the
full
inverse
mesenchymal-to-epithelial
(MET)
appears
fundamental
colonize
distant
secondary
sites.
EMT/MET
dynamics
granted
by
fine
modulation
gene
expression
response
intrinsic
extrinsic
signals.
In
this
complex
scenario,
long
non-coding
RNAs
(lncRNAs)
emerged
as
players.
This
review
specifically
focuses
on
lncRNA
HOTAIR,
master
regulator
plasticity
tumors.
Molecular
mechanisms
controlling
differentiated
well
trans-differentiated
are
highlighted
here.
Moreover,
current
knowledge
about
HOTAIR
pleiotropic
functions
regulation
both
protein
activities
described.
Furthermore,
relevance
specific
targeting
challenges
exploiting
for
therapeutic
approaches
counteract
discussed.
