Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1 DOI
Xujun You,

H X Li,

Qixin Li

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis DOI Creative Commons
Hanfei Zhang, Yuhao Li, Lin Li

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

Language: Английский

Citations

0
Synergistic effects of HO-1 inhibition and chemotherapy on tumor proliferation and immune infiltration: An in vitro and in vivo approach to enhancing prostate cancer treatment DOI
Ramia J. Salloom,

Dania Z. Sahtout,

Iman M. Ahmad

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102339 - 102339

Published: March 3, 2025

Language: Английский

Citations

0
Do cancer survivors have an increased risk of developing subsequent cancer? A population-based study DOI Creative Commons
Yubo Wang, Yining Jiang, Yang Bai

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 21, 2025

The number of cancer survivors has steadily increased due to earlier detection and more effective therapies. Do all types have an risk developing subsequent cancers compared with the general population? Patients diagnosed malignant between January 2000 December 2021 were included from SEER 17 Registries (excl AK) database. Events defined as at any site according ICD-O-3/WHO 2008. observed expected numbers retrieved, observed/expected (O/E) ratios excess risks calculated assess in United States population within same period. We obtained standard incidence for entire cohort stratified data by demographics, treatment, type. Our findings indicate that population, a 16% greater (p < 0.05). All subgroups also presented significantly cancers, even after stratification historic stage. Male patients prostate had 31% lower whereas female lung bronchus 93% risk. suggest nearly groups experienced men These differential provide clinicians evidence-based suggestions tailored surveillance prevention strategies. .

Language: Английский

Citations

0
Gut microbiome, dietary habits, and prostate cancer: a two-step Mendelian randomization revealing the causal associations DOI Creative Commons

Junhua Guo,

Ting Huang, Heran Zhou

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 23, 2025

Recent studies suggest that diet fizzy drinks may contribute to prostate cancer (PCa) development. However, the causal effects between and PCa whether gut microbiota (GM) act as a mediator remain unclear. We conducted two-sample Mendelian Randomization (MR) analyses utilizing large-scale genome-wide association (GWAS) data from UK Biobank, MiBioGen consortium, PCa-related datasets. The inverse-variance weighted (IVW) method was used evaluate of GM dietary preferences on risk. A mediation analysis performed investigate mediates relationship factors Diet drink consumption causally associated with reduced risk (OR = 0.83, 95% CI: 0.70–0.99, P 0.041) decreased abundance PCa-risk-related taxa (Negativicutes Selenomonadales). Mediation did not reveal statistically significant effect, proportion 16% (95% − 0.06–0.37, 0.13). Consumption reduce PCa, potentially through modulation GM; however, further are required confirm these findings clarify underlying mechanisms.

Language: Английский

Citations

0
Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1 DOI
Xujun You,

H X Li,

Qixin Li

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0