Cited by TRIM25 facilitates ferroptosis in ovarian cancer through promoting PIEZO1 K63-linked ubiquitination and degradation

Inhibition of Ovarian Cancer Growth, Metastasis and Reverse the Tumor Microenvironment by Dual Drug-Loaded Polymer Micelle Targeting Tumor Microenvironment DOI

Lu Zhang,

Rui-bo Guo,

Muhan Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2969 - 2990

Published: March 1, 2025

Introduction: Ovarian cancer is a malignant tumor that arises in the female reproductive system and associated with very high mortality rate. This primarily due to highly invasive nature of metastasis recurrence. Transforming immune environment from an immunosuppressive state anti-tumor through phenotypic transformation tumor-associated macrophages crucial for inhibiting growth, metastasis, recurrence ovarian cancer. Methods: A polymer micelle (RC-PH-Ms) containing paclitaxel (PTX) honokiol (HNK) was designed based on expression reactive oxygen species microenvironment. Once micelles are actively targeted microenvironment characterized by elevated levels species, responsive bond cleaved, thereby exposing secondary targeting ligand C7R. The released PTX HNK facilitate relevant M2 phenotype M1 phenotype, which turn inhibits invasion inhibit angiogenesis reduce Results: effects RC-PH-Ms modulating vascularization were investigated both vivo vitro. Conclusion: can significantly cancer, provides new perspective clinical treatment. Keywords: recrudescence, immunotherapy,

Language: Английский

Citations

Single nucleotide polymorphisms in ovarian cancer impacting lipid metabolism and prognosis: an integrated TCGA database analysis DOI

Haoyu Wang, Tian Ming Tu,

Lijun Yin

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

Ovarian cancer (OC) stands as a formidable adversary among women, remaining leading cause of cancer-related mortality owing to its aggressive and invasive nature. Investigating prognostic markers intricately linked OC's molecular pathogenesis represents critical avenue for enhancing patient outcomes survival prospects. In this comprehensive study, we embarked on bioinformatics journey, leveraging the vast repository single nucleotide polymorphism (SNP) data from OC patients available within TCGA database. Our overarching goal was unearth genetic underpinnings OC, shedding light potential that could significantly impact clinical decision-making care. meticulous analysis led discovery five mutated genes—APOB, BRCA1, COL6A3, LRP1, LRP1B—engaged in intricate world lipid metabolism. These genes, previously unexplored context emerged prominent figures our investigation, showcasing their roles progression. The interplay between metabolism development has garnered considerable attention recent years, findings underscore relevance these genes OC. To fortify discoveries, delved into realm analysis, pivotal component investigation. results yielded compelling evidence significant correlations expression levels aforementioned genes. This insight underscores utility markers, illuminating path toward more personalized effective approaches study multifaceted approach unraveling complex By harnessing power high-throughput mining, uncovered insights may reshape understanding disease. We complemented with advanced techniques such RT-qPCR Western blot, further dissecting intricacies landscape. holistic not only deepens but also provides essential information holds promise assessing prognosis. summary, stride quest decode ovarian cancer. spotlight significance APOB, LRP1B, inviting exploration Ultimately, research carries shape future management, offering glimpse

Language: Английский

Citations

GSH-responsive nanoparticles enhance ovarian cancer chemo-immunotherapy via DNA damage repair pathway inhibition and cGAS-STING pathway activation DOI

Miao Ao,

Hongyi Hou,

Libin Chen

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102729 - 102729

Published: March 25, 2025

Language: Английский

Citations

HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2 DOI

Ying Wang, Juan Chen,

Zhan Wang

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: April 15, 2025

Ovarian cancer (OC) is a significant health challenge, yet the mechanisms driving its progression remain unclear. This study explored role of hexokinase domain-containing protein 1 (HKDC1) in OC, focusing on tumor growth, lipid metabolism, and immune evasion. Human OC cell lines (SKOV3 HEY) murine line (ID8) were used to knock down overexpress HKDC1. An ID8-based epithelial mouse model was established validate vitro findings. Our results demonstrated that HKDC1 upregulated promoted proliferation, migration, invasion. enhanced accumulation by elevating levels free fatty acids (FFA), triglycerides, phospholipids, cholesterol, neutral lipid, while upregulating key enzymes (ACC1, FASN, SCD1, HMGCS1, HMGCR). It escape through PD-L1 upregulation, inhibiting T proliferation reducing IFN-γ, granzyme B, perforin increasing PD-1 levels. knockdown reversed these effects, which restored adding FFA. Mechanistically, interacted with stabilized glucose-6-phosphatase catalytic subunits (G6PC/G6PC2), supporting tumor-promoting functions. These findings confirmed an model, highlighting as driver biosynthesis suppression, offering potential therapeutic targets.

Language: Английский

Citations

TRIM25 facilitates ferroptosis in ovarian cancer through promoting PIEZO1 K63-linked ubiquitination and degradation DOI

Ya Li, Fei Zhou,

Zhengmei Xu

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 56, P. 102386 - 102386

Published: April 18, 2025

Language: Английский

Citations