Molecular understanding and clinical aspects of tumor-associated macrophages in the immunotherapy of renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: Aug. 22, 2024

Abstract Renal cell carcinoma (RCC) is one of the most common tumors that afflicts urinary system, accounting for 90–95% kidney cancer cases. Although its incidence has increased over past decades, pathogenesis still unclear. Tumor-associated macrophages (TAMs) are prominent immune cells in tumor microenvironment (TME), comprising more than 50% volume. By interacting with cells, TAMs can be polarized into two distinct phenotypes, M1-type and M2-type TAMs. In TME, TAMs, which known to promote tumorigenesis, abundant suppress growth. This ratio M1 M2 create an immunosuppressive environment contributes progression survival. review focused on role RCC, including their polarization, impacts proliferation, angiogenesis, invasion, migration, drug resistance, immunosuppression. addition, we discussed potential targeting clinical therapy RCC. A deeper understanding molecular biology essential exploring innovative therapeutic strategies treatment

Language: Английский

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Involvement of CXCL12/CXCR4 axis in colorectal cancer: a mini-review

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(7), P. 6233 - 6239

Published: May 23, 2023

Language: Английский

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Tumour-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signalling.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110701 - 110701

Published: Aug. 23, 2024

CMS4 colorectal cancer (CRC), based on the consensus molecular subtype (CMS), stratifies patients with poorest disease-free survival rates. It is characterized by a strong mesenchymal stromal cell (MSC) signature, wound healing-like inflammation and therapy resistance. We utilized 2D 3D

Language: Английский

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CXCL1/IGHG1 signaling enhances crosstalk between tumor cells and tumor-associated macrophages to promote MC-LR-induced colorectal cancer progression

Environmental Pollution, Journal Year: 2024, Volume and Issue: 351, P. 124081 - 124081

Published: April 30, 2024

Language: Английский

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Chemokines as Prognostic Factor in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5374 - 5374

Published: May 15, 2024

Chemokines orchestrate many aspects of tumorigenic processes such as angiogenesis, apoptosis and metastatic spread, related receptors are expressed on tumor cells well inflammatory (e.g., tumor-infiltrating T cells, TILs) in the microenvironment. Expressional changes chemokines their solid cancers common known, especially affecting colorectal cancer patient outcomes. Therefore, aim this current systematic review meta-analysis was to classify a prognostic biomarker patients. A literature search conducted PubMed, CENTRAL Web Science. Information chemokine expression 25 tissue survival data patients were investigated. The hazard ratio overall disease-free with examined. risk bias analyzed using Quality Prognosis Studies. Random effects performed determine impact respectively disease survival. For purpose, pooled ratios (HR) 95% confidence intervals (CI) used for calculation. Twenty-five included, revealed 5556 publications. total thirty-one publications included meta-analysis. Overexpression receptor CXCR4 associated both significantly reduced (HR = 2.70, 95%-CI: 1.57 4.66, p 0.0003) 2.68, 1.41 5.08, 0.0026). All other showed either heterogeneous results or few studies available. rated low. At level evidence, study demonstrates that overexpression is diminished Summed up, reveals promising biomarker. Nevertheless, more evidence needed evaluate its antagonists serving new therapeutic targets.

Language: Английский

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Altered expression of cytokines, chemokines, growth factors, and soluble receptors in patients with colorectal cancer, and correlation with treatment outcome

Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(9)

Published: July 2, 2024

Insofar as they play an important role in the pathogenesis of colorectal cancer (CRC), this study analyzes serum profile cytokines, chemokines, growth factors, and soluble receptors patients with CRC cancer-free controls possible signatures. Serum levels 65 analytes were measured age- sex-matched using ProcartaPlex Human Immune Monitoring 65-Plex Panel. Of tested analytes, 8 cytokines (CSF-3, IFN-γ, IL-12p70, IL-18, IL-20, MIF, TNF-α TSLP), chemokines (fractalkine, MIP-1β, BLC, Eotaxin-1, Eotaxin-2, IP-10, MIP-1a, MIP-3a), 2 factors (FGF-2, MMP-1), 4 (APRIL, CD30, TNFRII, TWEAK), differentially expressed CRC. ROC analysis confirmed high association TNF-α, APRIL, Tweak AUC > 0.70, suggesting theranostic application. The expression MMP1 was lower metastatic compared to non-metastatic CRC; only MIF MIP-1β 0.7. Moreover, MDC, IL-7, IL-21, are positively associated tolerance chemotherapy (CT) (AUC 0.7), whereas IL-31, Fractalkine, Eotaxin-2 resistance CT. may be used first-line early detection variable between cases assign prognostic nature these progression. Regarding CT, key when down-regulated or resistant treatment is observed.

Language: Английский

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Low transthyretin is associated with the poor prognosis of colorectal cancer

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 5, 2025

Objective To determine whether transthyretin (TTR) influences the prognosis of patients with colorectal cancers and establish a predictive model based on TTR. Methods Between January 2013 February 2019, clinical data 1322 CRC aged from 18 years to 80 who underwent surgical treatment were retrospectively analyzed. The preoperative TTR level, clinicopathological data, follow-up recorded. X-tile program was used optimal cut-off value. Cox proportional hazard regression analysis conducted evaluate correlation between cumulative incidence cancer-specific survival (CSS). Nomograms then developed predict CSS. Furthermore, an additional cohort 377 enrolled 2014 December 2015 included as external validation. Results Based value 121.3 mg/L, we divided into TTR-lower group (<121.3 mg/L) TTR-higher (≥121.3 mg/L). Comparative revealed that exhibited younger demographic, higher prevalence low cancers, elevated R0 resection rate, superior differentiation, earlier stage lower levels carcinoembryonic antigen (CEA) in contrast group. multivariable underscored significance various factors, encompassing age, tumor location, status, differentiation grade, disease stage, postoperative chemoradiotherapy, CEA levels, substantial prognostic indicators. nomogram, when internally externally assessed, demonstrated commendable performance across multiple metrics, including area under receiver operating characteristic curve (AUC), calibration plots, decision (DCA). Compared other models, hazards combined demonstrates terms C-index, AUC, chart, DCA within column chart. Conclusions identified factor for predicting long-term treatment, supporting its role biomarker practice.

Language: Английский

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Mutational signature-based biomarker to predict the response of immune checkpoint inhibitors therapy in cancers

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 308, P. 142585 - 142585

Published: March 28, 2025

Language: Английский

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Targeted protein degradation with small molecules for cancer immunotherapy

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101058 - 101058

Published: April 1, 2025

Language: Английский

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CCR9 shapes the immune microenvironment of colorectal cancer modulating the balance between intratumoral CD8+ T cell and FoxP3+ Helios+ Treg subpopulations

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321930 - e0321930

Published: April 30, 2025

Colorectal cancer (CRC) is the third most common in world and second cause of death related to cancer. Regulatory T cell (Treg) infiltration enriched several tumor types including CRC correlates with suppression anti-tumor immune response. In large intestine, thymic Tregs (tTregs Helios+) peripheral (pTregs Helios-) coexist maintain intestinal homeostasis under steady state conditions. The recruitment Treg cells intestine orchestrated by CCR9/CCL25 axis, which potentiated inflammatory Interestingly, balance between cytotoxic CD8+ within microenvironment critical for antitumor immunity progression. An elevated CD8+/Treg ratio has been associated improved clinical outcomes various cancers, CRC. Therefore, here we investigate potential role chemokine receptor CCR9 on effect subpopulations (Helios+ into using AOM/DSS induced colitis-associated colorectal murine model. Our findings reveal that deficiency leads distinct alterations microenvironment, characterized decreased intratumoral Helios+. Also, lack an improvement response, increasing infiltrate. These results underscore importance shaping during development.

Language: Английский

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