Long Noncoding RNAs and Cancer Stem Cells: Dangerous Liaisons Managing Cancer DOI Open Access
Silvia Anna Ciafrè,

Monia Russo,

Alessandro Michienzi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1828 - 1828

Published: Jan. 17, 2023

Decades of research have investigated the mechanisms that lead to origin cancer, striving identify tumor-initiating cells. These cells, also known as cancer stem are characterized by ability self-renew, give rise differentiated tumor populations, and on a larger scale, deemed responsible not only for initiation but recurrent tumors, often resistant chemotherapy radiotherapy. Long noncoding RNAs RNA molecules longer than 200 nt, lacking code proteins, with recognized roles fine regulators gene expression. They can exert these functions through variety mechanisms, acting at almost all steps expression, from modulation epigenetic state chromatin protein stability. In cases, lncRNAs do work alone, they always interact other molecules, either coding or non-coding, factors. this review, we summarize latest results obtained about involvement in initiating cells several types highlight different which work, while discussing how lncRNA affect aspects onset progression.

Language: Английский

Identification of copper metabolism-related subtypes and establishment of the prognostic model in ovarian cancer DOI Creative Commons
Songyun Zhao, Xin Zhang, Feng Gao

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 6, 2023

Ovarian cancer (OC) is one of the most common and malignant gynecological malignancies in gynecology. On other hand, dysregulation copper metabolism (CM) closely associated with tumourigenesis progression. Here, we investigated impact genes (CMRGs) on prognosis OC, discovered various CM clusters, built a risk model to evaluate patient prognosis, immunological features, therapy response.15 CMRGs affecting OC patients were identified The Cancer Genome Atlas (TCGA). Consensus Clustering was used identify two clusters. lasso-cox methods establish metabolism-related gene prognostic signature (CMRGPS) based differentially expressed GSE63885 cohort as an external validation cohort. Expression score-associated verified by single-cell sequencing quantitative real-time PCR (qRT-PCR). Nomograms visually depict clinical value CMRGPS. Differences traits, immune cell infiltration, tumor mutational load (TMB) between groups also extensively examined. Tumour Immune Dysfunction Rejection (TIDE) Phenotype Score (IPS) validate whether CMRGPS could predict response immunotherapy patients.In TCGA cohorts, clusters that differed significantly terms overall survival (OS) microenvironment. We then created containing 11 confirmed its reliable predictive power for patients. expression score-related validated qRT-PCR. Patients divided into low-risk (LR) high-risk (HR) median score, better LR group. 5-year AUC reached 0.74. Enrichment analysis showed group immune-related pathways. results TIDE IPS group.Our study, therefore, provides valuable tool further guide management tailor treatment offering new insights individualized treatment.

Language: Английский

Citations

63
FOXM1: A small fox that makes more tracks for cancer progression and metastasis DOI Creative Commons
Md Arafat Khan, Parvez Κhan,

Aatiya Ahmad

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 92, P. 1 - 15

Published: March 22, 2023

Language: Английский

Citations

59
Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer DOI Creative Commons
Hui Xu,

Haidan Luo,

Jiayu Zhang

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: March 20, 2023

Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory remains largely unknown. Here, we demonstrate that C.B reprograms proliferation, migration, stemness, tumor growth CRC by pivotal signal molecules including MYC. Destabilization MYC supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, boosts responsiveness anti-PD1 therapy. is a transcriptional regulator Thymidylate synthase (TYMS), key target 5-FU. Also known to impact on PD-1 expression. Mechanistically, treatment cells results degradation enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated resistance boosting immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between signaling, providing insight into tumorigenesis modulating mechanisms chemo/immune therapies.

Language: Английский

Citations

42
The role of stem cells in small-cell lung cancer: Evidence from chemoresistance to immunotherapy DOI Creative Commons

Wenwen Guo,

Tianyun Qiao,

Tian Li

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 87, P. 160 - 169

Published: Nov. 9, 2022

Small cell lung cancer (SCLC) is the most aggressive subtype of cancer, accounting for approximately 15 % among all cancers. Despite ability chemotherapy, first-line treatment SCLC, to rapidly shrink tumors, nearly patients experience recurrence and metastasis within a few months. Cancer stem cells (CSCs) are small population tumor responsible tumorigenesis, metastasis, after treatment, which play crucial role in chemoresistance by promoting DNA repair expression drug resistance-associated proteins. Thus, targeting CSCs has been successful certain malignancies. Tumor therapy entered era immunotherapy numerous preclinical trials have demonstrated effectiveness immunotherapeutic approaches CSCs, such as vaccines chimeric antigen receptor (CAR) T cell, feasibility combining them with chemotherapy. Therefore, deeper understanding interaction between immune system essential facilitate advances new immunotherapies well combination standard drugs This narrative review summarizes mechanisms SCLC latest targeted therapies. Thereafter, we discuss effects on microenvironment corresponding approaches. Eventually, propose that promising direction

Language: Английский

Citations

60
PROTACs: Novel tools for improving immunotherapy in cancer DOI
Shizhe Li, Ting Chen, Jinxin Liu

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 560, P. 216128 - 216128

Published: March 16, 2023

Language: Английский

Citations

25
A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and potential mechanisms DOI

Xiaoyang Guo,

Fan Nie,

Haojing Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140382 - 140382

Published: Jan. 1, 2025

Language: Английский

Citations

1
Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy DOI
Weijia Wang, Wenjun Liu, Qiuli Chen

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 87, P. 84 - 97

Published: Nov. 9, 2022

Language: Английский

Citations

30
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions DOI Creative Commons
Reem Khaled M.E. Alsayed,

Khalid Sultan A. M. Sheikhan,

Majid Alam

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 92, P. 74 - 83

Published: April 11, 2023

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cells indefinitely perpetuate as well differentiate. stem cell populations within a growing tumor also help evade inhibitory effects chemo- radiation-therapies, in addition playing an important role metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with stemness, thus presenting attractive targets for therapy. The interest non-coding RNAs (ncRNAs) recent years has provided further insight into mechanisms by which TFs influence characteristics. There evidence direct regulation ncRNAs, such as, microRNAs (miRNAs), (lncRNAs) circular (circRNAs), vice versa. Additionally, TF-ncRNAs regulations often indirect, involving ncRNA-target genes or sponging other ncRNA species individual ncRNAs. information rapidly evolving this review provides comprehensive interactions implications on stemness response therapies. Such knowledge will uncover many levels tight control providing novel opportunities therapy process.

Language: Английский

Citations

20
Functional Roles of CD133: More than Stemness Associated Factor Regulated by the Microenvironment DOI Creative Commons

Ángela Patricia Moreno-Londoño,

Martha Robles‐Flores

Stem Cell Reviews and Reports, Journal Year: 2023, Volume and Issue: 20(1), P. 25 - 51

Published: Nov. 3, 2023

Abstract CD133 protein has been one of the most used surface markers to select and identify cancer cells with stem-like features. However, its expression is not restricted tumoral cells; it also expressed in differentiated stem/progenitor various normal tissues. participates several cellular processes, part orchestrating signal transduction essential pathways that frequently are dysregulated cancer, such as PI3K/Akt signaling Wnt/β-catenin pathway. correlates enhanced cell self-renewal, migration, invasion, survival under stress conditions cancer. Aside from intrinsic mechanisms regulate each type, extrinsic factors surrounding niche can impact CD33 levels. The confer adaptive advantages by amplifying activation a specific pathway context-dependent manner. In this review, we do only describe physiological functions known so far, but importantly, analyze how microenvironment changes regulation emphasizing value marker adaptability beyond cancer-stem marker. Graphical

Language: Английский

Citations

20
FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases DOI Creative Commons
Zhenwang Zhang, Mengxi Li, Tian Sun

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 857 - 857

Published: May 18, 2023

Forkhead box (FOX) proteins are a wing-like helix family of transcription factors in the DNA-binding region. By mediating activation and inhibition interactions with all kinds transcriptional co-regulators (MuvB complexes, STAT3, β-catenin, etc.), they play significant roles carbohydrate fat metabolism, biological aging immune regulation, development, diseases mammals. Recent studies have focused on translating these essential findings into clinical applications order to improve quality life, investigating areas such as diabetes, inflammation, pulmonary fibrosis, increase human lifespan. Early shown that forkhead M1 (FOXM1) functions key gene pathological processes multiple by regulating genes related proliferation, cell cycle, migration, apoptosis diagnosis, therapy, injury repair. Although FOXM1 has long been studied relation diseases, its role needs be elaborated on. expression is involved development or repair including pneumonia, liver repair, adrenal lesions, vascular brain arthritis, myasthenia gravis, psoriasis. The complex mechanisms involve signaling pathways, WNT/β-catenin, STAT3/FOXM1/GLUT1, c-Myc/FOXM1, FOXM1/SIRT4/NF-κB, FOXM1/SEMA3C/NRP2/Hedgehog. This paper reviews kidney, vascular, lung, brain, bone, heart, skin, blood vessel elucidate progression non-malignant makes suggestions for further research.

Language: Английский

Citations

18