International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 1828 - 1828
Published: Jan. 17, 2023
Decades
of
research
have
investigated
the
mechanisms
that
lead
to
origin
cancer,
striving
identify
tumor-initiating
cells.
These
cells,
also
known
as
cancer
stem
are
characterized
by
ability
self-renew,
give
rise
differentiated
tumor
populations,
and
on
a
larger
scale,
deemed
responsible
not
only
for
initiation
but
recurrent
tumors,
often
resistant
chemotherapy
radiotherapy.
Long
noncoding
RNAs
RNA
molecules
longer
than
200
nt,
lacking
code
proteins,
with
recognized
roles
fine
regulators
gene
expression.
They
can
exert
these
functions
through
variety
mechanisms,
acting
at
almost
all
steps
expression,
from
modulation
epigenetic
state
chromatin
protein
stability.
In
cases,
lncRNAs
do
work
alone,
they
always
interact
other
molecules,
either
coding
or
non-coding,
factors.
this
review,
we
summarize
latest
results
obtained
about
involvement
in
initiating
cells
several
types
highlight
different
which
work,
while
discussing
how
lncRNA
affect
aspects
onset
progression.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 4, 2024
Genetic
studies
implicate
the
oncogenic
transcription
factor
Forkhead
Box
M1
(FOXM1)
as
a
potential
therapeutic
target
in
high-grade
serous
ovarian
cancer
(HGSOC).
We
evaluated
activity
of
different
FOXM1
inhibitors
HGSOC
cell
models.
treated
and
fallopian
tube
epithelial
(FTE)
cells
with
panel
previously
reported
inhibitors.
Based
on
drug
potency,
efficacy,
selectivity,
determined
through
viability
assays,
we
focused
two
compounds,
NB-73
NB-115
(NB
compounds),
for
further
investigation.
NB
compounds
potently
selectively
inhibited
lesser
effects
other
FOX
family
members.
decreased
expression
via
targeting
protein
by
promoting
its
proteasome-mediated
degradation,
effectively
suppressed
gene
targets
at
both
mRNA
level.
At
cellular
level,
promoted
apoptotic
death.
Importantly,
while
inhibition
apoptosis
using
pan-caspase
inhibitor
rescued
from
compound-induced
death,
it
did
not
rescue
supporting
that
loss
compound
treatment
is
specific
general
consequence
cytotoxicity.
Drug
washout
indicated
reduction
was
retained
least
72
h
post-treatment,
suggesting
exhibit
long-lasting
cells.
two-dimensional
three-dimensional
colony
formation
sub-micromolar
concentrations.
Finally,
exhibited
synergistic
carboplatin
are
potent,
selective,
efficacious
worthy
investigation
therapeutics.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 6, 2025
Abstract
The
proliferation-specific
oncogenic
transcription
factor,
FOXM1
is
overexpressed
in
primary
and
recurrent
breast
tumors
across
all
cancer
(BC)
subtypes.
Intriguingly,
overexpression
was
found
to
be
highest
Triple-negative
(TNBC),
the
most
aggressive
BC
with
worst
prognosis.
However,
FOXM1-mediated
TNBC
pathogenesis
not
completely
elucidated.
Single
nucleotide
polymorphisms
(SNPs)
are
common
genetic
variations
causing
functional
structural
aberrations
proteins
enhancing
susceptibility.
This
computational
investigation
attempted
identify
malignant
non-synonymous
SNPs
(nsSNPs)
evaluate
their
role
affecting
conformational
stability,
evolutionary
conservation,
post-translational
modifications,
susceptibility
of
protein.
Out
a
huge
data
pool
8826
using
several
in-silico
sequence-based
tools
approaches,
four
viz.
E235Q,
R256C,
G429E
S756P
were
identified
as
pathogenic
nsSNPs
among
shortlisted
variants
molecular
dynamics
simulations
E235Q
damaging
SNP,
followed
by
S756P.
Additionally,
defective
drug
DNA
binding
motif
also
determined
our
study.
Thus,
although
further
in-vitro
validations
awaited
findings
this
work
can
used
blueprint
for
nsSNP
identification
aiding
clinical
therapeutics.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 1828 - 1828
Published: Jan. 17, 2023
Decades
of
research
have
investigated
the
mechanisms
that
lead
to
origin
cancer,
striving
identify
tumor-initiating
cells.
These
cells,
also
known
as
cancer
stem
are
characterized
by
ability
self-renew,
give
rise
differentiated
tumor
populations,
and
on
a
larger
scale,
deemed
responsible
not
only
for
initiation
but
recurrent
tumors,
often
resistant
chemotherapy
radiotherapy.
Long
noncoding
RNAs
RNA
molecules
longer
than
200
nt,
lacking
code
proteins,
with
recognized
roles
fine
regulators
gene
expression.
They
can
exert
these
functions
through
variety
mechanisms,
acting
at
almost
all
steps
expression,
from
modulation
epigenetic
state
chromatin
protein
stability.
In
cases,
lncRNAs
do
work
alone,
they
always
interact
other
molecules,
either
coding
or
non-coding,
factors.
this
review,
we
summarize
latest
results
obtained
about
involvement
in
initiating
cells
several
types
highlight
different
which
work,
while
discussing
how
lncRNA
affect
aspects
onset
progression.
