Role of glycolysis in inflammatory bowel disease and its associated colorectal cancer DOI Creative Commons
Yuxuan Xia, Zhang Li, Dickson Kofi Wiredu Ocansey

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 10, 2023

Inflammatory bowel disease (IBD) has been referred to as the “green cancer,” and its progression colorectal cancer (CRC) poses a significant challenge for medical community. A common factor in their development is glycolysis, crucial metabolic mechanism of living organisms, which also involved other diseases. In IBD, glycolysis affects gastrointestinal components such intestinal microbiota, mucosal barrier function, immune system, including macrophages, dendritic cells, T neutrophils, while CRC, it linked various pathways, phosphatidylinositol-3-kinase (PI3K)/AKT, AMP-activated protein kinase (AMPK), mammalian target rapamycin (mTOR), transcription factors p53, Hypoxia-inducible (HIF), c-Myc. Thus, comprehensive study essential better understanding pathogenesis therapeutic targets both IBD CRC. This paper reviews role diseases, particularly via effects on immunity, integrity, signaling some strategies targeting glycolytic enzymes.

Language: Английский

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

Citations

48
Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications DOI Open Access
Yue Wang,

Xiaodan Jia,

Shangjie An

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 5, 2023

Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.

Language: Английский

Citations

43
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism DOI Creative Commons
Shiwei Yue, Hailing Liu,

Hong-Fei Su

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 15, 2023

Abstract Glycolytic reprogramming is one of the most important features cancer and plays an integral role in progression cancer. In cells, changes glucose metabolism meet needs self-proliferation, angiogenesis lymphangiogenesis, metastasis, also affect immune escape, prognosis evaluation therapeutic effect The n6-methyladenosine (m6A) modification RNA widespread eukaryotic cells. Dynamic reversible m6A modifications are widely involved regulation stem cell renewal differentiation, tumor therapy resistance, microenvironment, metabolism. Lately, more evidences show that can glycolysis process tumors a variety ways to regulate biological behavior tumors. this review, we discussed genesis development, elaborated detail profound impact on different by regulating glycolysis. We believe modified has great significance potential for treatment.

Language: Английский

Citations

42
By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma DOI Creative Commons
Pengpeng Zhang,

Shengbin Pei,

Zetian Gong

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 27, 2023

Lung adenocarcinoma (LUAD) is a heterogeneous disease with dismal prognosis for advanced tumors. Immune-associated cells in the microenvironment substantially impact LUAD formation and progression, which has gained increased attention recent decades. Sphingolipids have profound on tumor immune infiltration. However, few researchers focused utilization of sphingolipid variables prediction prognosis. The goal this work was to identify major sphingolipid-related genes (SRGs) develop valid prognostic model based SRGs.The most significant metabolism (SM) were identified using AUCell WGCNA algorithms conjunction single-cell bulk RNA-seq. LASSO COX regression analysis used risk models, patients divided into high-and low-risk categories. External nine provided cohorts evaluated correctness models. Differences infiltration, mutation landscape, pathway enrichment, checkpoint expression, immunotherapy also further investigated distinct subgroups. Finally, cell function assay verify role CACYBP cells.A total 334 selected as being linked SM activity investigation, consisting 11 established lasso cox regression. According median value, split high- groups, high-risk group had worse more infiltration higher expression checkpoints, illustrated that likely benefit from immunotherapy. It verified could increase ability proliferate, invade, migrate.The eleven-gene signature research may help physicians create individualized care plans patients. be new therapeutic target LUAD.

Language: Английский

Citations

41
Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD DOI Creative Commons
Yang Long,

Kunwei Niu,

Jianlin Wang

et al.

Journal of Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Intrahepatic cholangiocarcinoma (iCCA) is a fatal malignancy of the biliary system. The lack detailed understanding oncogenic signaling or global gene expression alterations has impeded clinical iCCA diagnosis and therapy. role protein lactylation, newly unraveled post-translational modification that orchestrates expression, remains largely elusive in pathogenesis iCCA.

Language: Английский

Citations

28
Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy DOI

Shuang Zeng,

Zhihan Guo,

Yifu Hao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786

Published: March 20, 2024

Language: Английский

Citations

25
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment DOI Creative Commons
Tian Lan, Fengwei Gao, Yunshi Cai

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Metabolic reprogramming fuels cancer cell metastasis and remodels the immunosuppressive tumor microenvironment (TME). We report here that circPETH, a circular RNA (circRNA) transported via extracellular vesicles (EVs) from tumor-associated macrophages (TAMs) to hepatocellular carcinoma (HCC) cells, facilitates glycolysis in recipient HCC cells. Mechanistically, circPETH-147aa, encoded by circPETH an m6A-driven manner, promotes PKM2-catalyzed ALDOA-S36 phosphorylation MEG pocket. Furthermore, circPETH-147aa impairs anti-HCC immunity increasing HuR-dependent SLC43A2 mRNA stability driving methionine leucine deficiency cytotoxic CD8+ T Importantly, through virtual experimental screening, we find small molecule, Norathyriol, is effective inhibitor targets pocket on surface. Norathyriol reverses circPETH-147aa-facilitated acquisition of metabolic metastatic phenotypes increases anti-PD1 efficacy, enhances T-cell function. Here show promising agent contributes attenuating resistance advanced immune checkpoint blocker (ICB) therapies. Tumor-associated are associated with poor prognosis low responses immunotherapy. Here, authors discover RNA, produced TAMs generates activity CD8 +

Language: Английский

Citations

2
Mannose-Modified Multifunctional Iron-Based Nanozyme for Hepatocellular Carcinoma Treatment by Remodeling the Tumor Microenvironment DOI
Qi Liu, Ziwei Liang, Jiapu Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114548 - 114548

Published: Feb. 3, 2025

Language: Английский

Citations

2
circROBO1 promotes prostate cancer growth and enzalutamide resistance via accelerating glycolysis DOI Creative Commons
Zhigang Zhou, Jing Qin, Cailu Song

et al.

Journal of Cancer, Journal Year: 2023, Volume and Issue: 14(13), P. 2574 - 2584

Published: Jan. 1, 2023

Background and aim:As non-coding RNAs, circular RNAs (circRNAs) contribute to the progression of malignancies by regulating various biological processes.In prostate cancer, however, there is still a lack understanding regarding potential molecular pathways roles circRNAs.Methods: Loss-off function experiments were performed investigate circRNA in cancer.Western blot, qRT-PCR, IHC assay used examine expression level different genes or circRNAs.Further biology conducted uncover mechanism underlying cancer using dual luciferase reporter RNA immunoprecipitation (RIP) assays.Results: A novel (hsa_circ_0124696, named circROBO1) was identified as significantly upregulated both cells tissues.Suppression circROBO1 attenuated proliferation cells.In addition, we found that knockdown remarkably increased sensitivity enzalutamide treatment.A deceleration glycolysis rate observed after inhibition circROBO1, which could suppress growth overcome resistance enzalutamide.Our results revealed promotes via accelerating glycolysis. Conclusion:Our study role circROBO1-miR-556-5p-PGK1 axis therapeutic target cancer.

Language: Английский

Citations

38
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement DOI Creative Commons
Cong Zhang, Huixia Judy Wang, Qingwei Liu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: Sept. 23, 2023

Gastric cancer (GC) is one of the most prevalent malignant tumors digestive system. As a hallmark cancer, energy-related metabolic reprogramming manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as crucial regulator in tumor progression. Nevertheless, precise molecular mechanisms underlying involvement GC remain unclear. Gain- and loss-of-function experiments were performed to evaluate roles tumorigenesis glycolysis GC. Bioinformatics analyses mechanistic experiments, such mass spectrometry (MS), RNA-pulldown, RNA immunoprecipitation (RIP), employed reveal potential interacting protein elucidate regulatory mechanism glycolysis. Moreover, nude mice xenograft assay was used effect on cells vivo. In this study, we that expression significantly elevated tissues plasma exosomes patients, well cell lines. Functional showed knockdown resulted substantial decrease proliferation, migration invasion both vitro vivo through decreasing glycolytic enzymes rate. Conversely, overexpression exhibited contrasting effects. Mechanistically, interacted with PTBP1 effectively maintained its stability inhibiting ubiquitin-mediated degradation process. critical splicing factor, facilitated transition from PKM1 PKM2, thereby augmenting activity ultimately fostering progression Our findings demonstrate plays significant role promoting migration, PTBP1/PKM2/glycolysis pathway, thus suggesting CCAT1's biomarker therapeutic target for

Language: Английский

Citations

24