Regulation of transcription factor function by purinergic signalling in cardiovascular diseases DOI
Hao Tang,

Qihang Kong,

Zhewei Zhang

et al.

Purinergic Signalling, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Language: Английский

Mannose-Binding Lectin 2 as a Potential Therapeutic Target for Hepatocellular Carcinoma: Multi-Omics Analysis and Experimental Validation DOI Open Access

Hangyu Liao,

Jun Yang, Yuyan Xu

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(19), P. 4900 - 4900

Published: Oct. 9, 2023

Mannose-binding lectin 2 (MBL2), a member of the multimeric family, is crucial in immune regulation and tumor development. MBL2 gene polymorphisms are associated with risk prognosis various tumors, including hepatocellular carcinoma (HCC). Its functional role HCC remains largely unclear. In this study, we aimed to identify whether key regulator potential therapeutic target for HCC. A bioinformatics analysis revealed close relationships among downregulation, tumor-associated proliferation metastasis pathway, immunosuppressive microenvironments. Lower expression patients was linked an unfavorable prognosis. cell counting kit-8 assay, colony formation transwell migration wound healing assay further confirmed that overexpression could directly inhibit Moreover, regulated by miR-34c-3p, as dual-luciferase reporter thereby demonstrating progression cells. Thus, our study offers first comprehensive confirmation development through multi-omics experimental validation. Furthermore, miR-34c-3p found be upstream mechanism downregulation promising target, expanding treatment options

Language: Английский

Citations

2
Quantitative secretomics identifies ligand-receptor pairs in pancreatic cancer that mediate bidirectional crosstalk between cancer stem cells and nociceptors DOI Creative Commons
Chao‐Hui Chang, Feng Liu, Siwei Deng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 29, 2024

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest and most metastatic cancers in human. PDACs respond poorly to therapies, partly due cancer stem cells (CSCs) that self-renew, survive chemotherapies, metastasise replenish tumour. Factors secreted by tumour mediate autocrine/paracrine crosstalk with surroundingcells contributing cell niche but are still insufficiently characterised. Here we used quantitative SILAC proteomics identify factors enriched CSC secretome compared non-CSCs. Among them were GDF15 VGF, involved cachexia pain stimuli. VGF promoted self-renewal growth through autocrine effects. TGFβ/Activin signalling lowered expression via SMAD2/3-SMAD4-SNON, switching ATF4-CREB-mediated induction upon stress. Co-culture PDAC-CSCs hESC-derived neural for mimicking cellular PDAC revealed paracrine GDF15/VGF nociceptor formation neurite outgrowth. In turn, Substance P from neurons supported self-renewal, EMT/migration clonal evolution was also impacted SMAD4 genetic status. Lastly, serum levels elevated patients suggesting their utility as biomarkers detection. Collectively, our data uncovered between CSCs nociceptors.

Language: Английский

Citations

0
CD146, a therapeutic target involved in cell plasticity DOI
Zhenhua Wu,

Yuzhe Zang,

Chuyi Li

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: 67(8), P. 1563 - 1578

Published: April 9, 2024

Language: Английский

Citations

0
Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma DOI
Wanxiang Niu, Huihan Yu,

Xiaoqing Fan

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 120, P. 111231 - 111231

Published: May 18, 2024

Language: Английский

Citations

0
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases DOI
Hao Tang,

Qihang Kong,

Zhewei Zhang

et al.

Purinergic Signalling, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

Language: Английский

Citations

0