Association of STAT6 Gene Polymorphism with Atopic Asthma among Yemeni Children in Sana'a City, Yemen

Published: March 31, 2025

Background Asthma is the most common chronic illness in children and characterized by airway hyperresponsiveness, increased production of mucus, significant inflammation. The signal transducer activator transcription 6 (STAT6) a crucial gene immune response, specifically atopic reactions. It plays role IL-4 IL-13 signaling pathways asthma allergies. Objective This study aimed to determine association between STAT6 rs324011 polymorphism among Yemeni as well investigate impact on IL-13, total IgE, eosinophils. Methods included 75 diagnosed with bronchial healthy controls matched for age sex. (rs324011) was genotyped using RFLP PCR, serum level measured via ELISA, IgE electrochemiluminescence. Results Under recessive model, TT genotype significantly associated an risk compared CC CT genotypes (χ² = 6.6, OR = 2.5, CI 1.2–5, p 0.01). levels asthmatic were elevated individuals those or (p=0.04). Conclusion T allele may be susceptibility pediatric children.

Language: Английский

---

Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: April 2, 2024

Cancer stem cells (CSCs) were first discovered in the 1990s, revealing mysteries of cancer origin, migration, recurrence and drug-resistance from a new perspective. The expression pluripotent genes complex signal regulatory networks are significant features CSC, also act as core factors to affect characteristics CSC. Transcription is necessary link regulate phenotype potential involving chromatin environment, nucleosome occupancy, histone modification, transcription factor (TF) availability cis-regulatory elements, which suffer ambient pressure. Especially, activity TFs deeply affected by both internal external factors, foundation CSC transcriptional regulation current research framework. Growing evidence indicates that regulating epigenetic modifications alter stemness effective, some special promoters enhancers can serve targets influence properties Clarifying will assist us directly target key TFs, or hinder through environmental other related order achieve goal inhibiting tumors. This paper comprehensively reviews traditional aspects regulation, explores progress insights impact on status tumor microenvironment (TME), hypoxia, metabolism meaningful conjunction with latest research. Finally, we present opinions omnidirectional targeting CSCs eliminate address resistance.

Language: Английский

---

RXR signaling targeted cancer therapy

The Innovation Life, Journal Year: 2023, Volume and Issue: 1(1), P. 100014 - 100014

Published: Jan. 1, 2023

<sec><p>Retinoic X receptor (RXR) acts as a critical player in regulating series of genetic transcriptions cancer cells since it heterodimerizes with third nuclear receptors (NRs). However, RXR-targeted therapy was greatly undervalued. Bexarotene (Targretin®) the first synthetic rexinoid that approved by Food and Drug Administration for refractory cutaneous T-cell lymphoma treatment 2000. Afterward, researchers started to focus more on function RXR modifications RXR, such phosphorylated-RXRα (p-RXRα) truncated RXRα (tRXRα). Meanwhile, RXR-modulating drugs began attract interest from oncologists because their potential interfering cell proliferation, differentiation, apoptosis according important comprehensive regulation effects tumorigenesis.</p></sec><sec><p>Herein, we will review role between signaling oncogenesis, highlighted undervalued rexinoid-related therapy, discuss propose its great future clinics.</p></sec>

Language: Английский

---

Deciphering Regulatory T-Cell Dynamics in Cancer Immunotherapy: Mechanisms, Implications, and Therapeutic Innovations

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(8), P. 2215 - 2236

Published: July 3, 2024

This Review explores how tumor-associated regulatory cells (Tregs) affect cancer immunotherapy. It shows Tregs play a role in keeping the immune system check, cancers grow, and well immunotherapy work. use many ways to suppress system, these are affected by tumor microenvironment (TME). New approaches therapy showing promise, such as targeting Treg checkpoint receptors precisely using Fc-engineered antibodies. is important tailor treatments each patient's TME order provide personalized care. Understanding biology essential for creating effective improving long-term outcomes of

Language: Английский

---

Oral membrane-biomimetic nanoparticles for enhanced endocytosis and regulation of tumor-associated macrophage

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 4, 2023

Abstract Enterocyte uptake with high binding efficiency and minor endogenous interference remains a challenge in oral nanocarrier delivery. membrane-biomimetic lipids may universally cooperate phosphatidyl choline via biorthogonal group. In this study, we developed sophorolipid-associated phosphate-poly(lactic- co -glycolic) acid hybrid nanoparticle (SDPN). Aided by physical stability the gastrointestinal tract rapid mucus diffusion provided association sophorolipid, these nanoparticles show improved endocytosis, driven dipalmitoyl phosphate-phosphatidyl interaction as well its optimized membrane fluidity rigidity. Luteolin- silibinin-co-loaded SDPN alleviated breast cancer metastasis 4T1 tumor-bearing mice regulating conversion of tumor-associated M2 macrophages into M1 phenotype reducing proportion M2-phenotype through co-action on STAT3 HIF-1α. addition, reduces angiogenesis regulates matrix barrier tumor microenvironment. conclusion, strategy is promising for improving enterocyte shows potential to alleviate metastasis.

Language: Английский

---

Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 841 - 841

Published: Sept. 29, 2023

Background: The most common type of breast cancer is the ductal (IDC), followed by lobular (ILC). Surgery main therapy for early-stage cancer. Adjuvant chemotherapy might be given to those at high risk recurrence. We aimed determine mechanisms in early local recurrence both types. Methods: An observational case-controlled study was used. Early-stage IDC and ILC patients who received modified radical mastectomy (MRM) adjuvant taxan anthracycline base had within two years. examined vimentin, α-smooth muscle actin (SMA), matrix metalloproteinase (MMP1), platelet-derived growth factor (PDGF), clustered differentiation (CD95) Results: In group, there were 25 samples revealing that did not recur. group comprised six participants have a recurrence, while seven subjects There significant differences expression vimentin (p = 0.000 0.021, respectively), PDGF 0.002), CD95 0.045) types, respectively. MMP1 0.000) α-SMA only showed difference type. pathway analysis type, mechanism enabled factors: CD95. Meanwhile, through pathway. Conclusions: tumor microenvironment immune system affect IDC, whereas more important ILC. This suggests enhancement may an option treating cancer.

Language: Английский

---

Targeting cancer stem cell plasticity in triple-negative breast cancer

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2023, Volume and Issue: 4(6), P. 1165 - 1181

Published: Dec. 11, 2023

Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited treatment options. Cancer stem cells (CSCs) are thought to play crucial role in TNBC progression and resistance therapy. CSCs small subpopulation of within tumors that possess self-renewal differentiation capabilities responsible for tumor initiation, maintenance, metastasis. exhibit plasticity, allowing them switch between states adapt changing microenvironments. Targeting CSC plasticity has emerged as promising strategy treatment. This review summarizes recent advances understanding the molecular mechanisms underlying discusses potential therapeutic approaches targeting plasticity.

Language: Английский

---

Special issue: Deregulated transcription factors in the cancer therapeutic challenges: An update on cancer stemness features

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 96, P. 3 - 4

Published: Sept. 9, 2023

Language: Английский

---

Deciphering the implications of mitophagy-related signatures in clinical outcomes and microenvironment heterogeneity of clear cell renal cell carcinoma

Journal of Cancer Research and Clinical Oncology, Journal Year: 2023, Volume and Issue: 149(17), P. 16015 - 16030

Published: Sept. 9, 2023

Language: Английский

---

Unveiling the STAT3-ACC1 axis: a key driver of lipid metabolism and tumor progression in non-small cell lung cancer

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(8), P. 2340 - 2353

Published: Jan. 1, 2024

Lung cancer is a prevalent global malignancy, and investigating the metabolic reprogramming of tumor cells has significant therapeutic implications. This study aims to explore molecular mechanism driving progression non-small cell lung (NSCLC), with specific emphasis on STAT3-ACC1-FAS axis involved in fatty acid synthesis.

Language: Английский

---