Diet induced thermogenesis, older and newer data with emphasis on obesity and diabetes mellitus - A narrative review DOI Creative Commons
Evangelia Tzeravini, Anastasios Tentolouris, Alexander Kokkinos

et al.

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100291 - 100291

Published: June 1, 2024

Obesity is a major public health problem with prevalence increasing at an alarming rate worldwide. There urgent need for efficient approaches to weight management. Diet induced thermogenesis (DIT) the process by which body increases its energy expenditure in response meal. It estimated account approximately 10% of total and considered potentially modifiable component expenditure. The palatability food, meal's composition macronutrients, circadian rhythm sleep, as well individual's characteristics such age sex, presence obesity or diabetes mellitus, proportion physical activity are main factors that affect DIT. However, studies examining DIT mostly characterized small sample size methodology varies considerably between studies. seems even today there lot contradiction relative Inspite that, future research might lead modification order achieve some loss obese people.

Language: Английский

Trabecular Bone Score as a Complementary Tool for the Assessment of Bone Mineral Density in Patients with Asymptomatic Monoclonal Gammopathies DOI Open Access

Styliani Drakoulidou,

Ioannis Ntanasis‐Stathopoulos, Aikaterini Kyritsi

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6461 - 6461

Published: Oct. 28, 2024

Background/Objectives: Monoclonal gammopathies, such as Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM), are conditions marked by the overproduction specific monoclonal proteins. Patients with these known to have a higher risk fractures compared general population, yet there no established guidelines for assessing or managing their skeletal health. The Trabecular Bone Score (TBS), which can be calculated from DXA images lumbar spine, provides additional insights into bone microarchitecture. Methods: This study aimed determine whether TBS serve supplementary tool in loss MGUS SMM patients. Conducted 2020 2023, involved 148 participants—74 diagnosed myeloma precursor state 74 healthy controls—who underwent simultaneous measurements. Results: results indicated weak positive correlation (R = 0.405) between T-scores, suggesting that other factors may influence When analyzed separately, correlations remained both 0.250) 0.485). Interestingly, discrepancies were noted T-score classifications; instance, patient classified normal via could deemed osteopenic osteoporotic TBS. Conclusions: Overall, findings suggest incorporating alongside enhance accuracy density assessments, facilitating earlier diagnosis treatment initiation osteoporosis asymptomatic patients gammopathies.

Language: Английский

Citations

0
Preclinical delayed toxicity studies of BCMA CAR T-cell injection in B-NDG mice with multiple myeloma DOI Creative Commons
Jianmin Guo,

Qiqi Wu,

Hongjian Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Purpose Based on the efficacy data from previous study of B-cell maturation antigen (BCMA) chimeric receptor (CAR) T-cell injection, we further examined delayed toxicity for 8 weeks after a single dose BCMA CAR injection to observe possible toxic reactions. Methods B-NDG mice transplanted with multiple myeloma (MM) cells were given at two dosages or human normal T and then subjected examinations including clinical signs, weight food intake measurements, haematology, blood biochemical analysis, cytokine assay, T-lymphocyte subpopulation quantification histopathology days 28 56 dosing. In addition, quantitative polymerase chain reaction (qPCR) was used quantify DNA fragments in different tissues assess tissue distribution provide basis its preclinical safety evaluation Results study, no mortality significant effects such as reductions intake, body weight, relevant parameters target organ weights observed T-cell-treated groups. Compared model group, restorative changes signs clinicopathology indicating therapeutic seen Human-derived cytokines interleukin-2 (IL-2), IL-4, IL-6, IL-12, IL-10, tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ) could be detected all cancer cell–bearing by level measurement. IFN-γ levels showed geometric increase due graft versus host disease (GVHD) response induced mice, while other did not show changes. Histopathological examination indicated that treatment groups mixed cellular infiltration human-derived cells, inflammatory several organs liver, spleen, lung, kidney, some them mild damage, but number animals severity damage significantly less than those control group well group. The results mainly concentrated bone marrow related immune organs/tissues, highly consistent MM suggesting follow during metastatic targeting tissues. Conclusions present demonstrated low manageable side good anticancer activity without observable adverse effects. This provides support future studies MM.

Language: Английский

Citations

0
Associations between patient characteristics and progression to multiple myeloma among patients with monoclonal gammopathy of undetermined significance: A systematic review DOI
Yan Li,

Sylvia H. Hsu,

Rong Wang

et al.

Clinical Lymphoma Myeloma & Leukemia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Surgical Margin and Other Prognostic Factors of Invasive Vulvar Squamous Cell Carcinoma: A Clinicopathological Mono-center Study DOI Creative Commons

Binghong Guo,

Jiaqi Qiu,

Yulin Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(24), P. e41042 - e41042

Published: Dec. 1, 2024

To evaluate prognostic factors in women with invasive VSCC at Sun Yat-sen University Cancer Center (SYSUCC). 137 patients SYSUCC were retrospectively analyzed. The Kaplan-Meier method assessed the overall survival (OS) and progression-free (PFS) time. Prognostic identified using univariable multivariable Cox regression analysis. Only 2 out of had positive postoperative margins after intraoperative supplemental excision. international federation gynecology obstetrics (FIGO) Stage III-IV (HR: 4.67, 95 % confidence intervals (CI): 2.48-8.79) BMI ≥25 kg/m2 1.86, CI: 1.08-3.23) independent risk for OS. affecting PFS included FIGO stage 3.72, 2.10-6.60), 2.15, 1.28-3.64), squamous cell carcinoma antigen (SCC-Ag) > 1.5 ng/ml 2.06, 1.23-3.47). 12 individuals perineural invasion (PNI) was extremely poor, a median OS 37 months 22 months. surgical margin should be least 1.0 cm away from tumor edge. When surgeons cannot ensure negative margins, detecting rapid pathological examination may reduce incidence margins. III-IV, ILN metastases, are important adverse patients. Cases PNI have poor prognosis. SCC-Ag might useful marker predicting relapse.

Language: Английский

Citations

0
Diet induced thermogenesis, older and newer data with emphasis on obesity and diabetes mellitus - A narrative review DOI Creative Commons
Evangelia Tzeravini, Anastasios Tentolouris, Alexander Kokkinos

et al.

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100291 - 100291

Published: June 1, 2024

Obesity is a major public health problem with prevalence increasing at an alarming rate worldwide. There urgent need for efficient approaches to weight management. Diet induced thermogenesis (DIT) the process by which body increases its energy expenditure in response meal. It estimated account approximately 10% of total and considered potentially modifiable component expenditure. The palatability food, meal's composition macronutrients, circadian rhythm sleep, as well individual's characteristics such age sex, presence obesity or diabetes mellitus, proportion physical activity are main factors that affect DIT. However, studies examining DIT mostly characterized small sample size methodology varies considerably between studies. seems even today there lot contradiction relative Inspite that, future research might lead modification order achieve some loss obese people.

Language: Английский

Citations

0