Assessment of Nephroprotective Properties of Vitex Agnus castus Extract in Cisplatin-Treated Wistar Rats: A Pilot Study DOI Open Access
Aparna Tripathy, Babi Dutta,

Archana Parampalli Raghavendra

et al.

Biomedical & Pharmacology Journal, Journal Year: 2024, Volume and Issue: 17(4), P. 2593 - 2605

Published: Dec. 30, 2024

Background: Cisplatin (CP) is used to treat various solid tumors but associated with nephrotoxicity, which varies dose and duration. Vitex Agnus castus (VAC) berries, known for their anti-inflammatory antioxidant properties, may alleviate CP-induced renal toxicity. Objective: To investigate the gender-specific responses cisplatin-induced nephrotoxicity evaluate VAC extract's nephroprotective effects. Methods: Four-month-old Wistar rats (n=36) (24 male, 12 female) were used. In phase 1, gender-based differences in assessed. The gender group higher was selected 2 VAC's properties. Animals randomly grouped as Normal Control (6 males & 6 females), CP females) received (7 mg/kg bw) injection, (received 165 bw 7 days daily), CP+VAC (CP injection followed by orally days). Results: CP-treated male showed significantly plasma creatinine, urea, BUN levels (p<0.05) than controls, while female slight increases. Male chosen 2, where treatment post-CP lowered kidney function parameters, though not compared controls. Histopathology revealed severe tubular damage dilation kidneys Conclusion: causes acute injury, showing more nephrotoxicity. extract reduced biochemical markers of did reverse damage, suggesting potential mitigation some

Language: Английский

Assessment of Nephroprotective Properties of Vitex Agnus castus Extract in Cisplatin-Treated Wistar Rats: A Pilot Study DOI Open Access
Aparna Tripathy, Babi Dutta,

Archana Parampalli Raghavendra

et al.

Biomedical & Pharmacology Journal, Journal Year: 2024, Volume and Issue: 17(4), P. 2593 - 2605

Published: Dec. 30, 2024

Background: Cisplatin (CP) is used to treat various solid tumors but associated with nephrotoxicity, which varies dose and duration. Vitex Agnus castus (VAC) berries, known for their anti-inflammatory antioxidant properties, may alleviate CP-induced renal toxicity. Objective: To investigate the gender-specific responses cisplatin-induced nephrotoxicity evaluate VAC extract's nephroprotective effects. Methods: Four-month-old Wistar rats (n=36) (24 male, 12 female) were used. In phase 1, gender-based differences in assessed. The gender group higher was selected 2 VAC's properties. Animals randomly grouped as Normal Control (6 males & 6 females), CP females) received (7 mg/kg bw) injection, (received 165 bw 7 days daily), CP+VAC (CP injection followed by orally days). Results: CP-treated male showed significantly plasma creatinine, urea, BUN levels (p<0.05) than controls, while female slight increases. Male chosen 2, where treatment post-CP lowered kidney function parameters, though not compared controls. Histopathology revealed severe tubular damage dilation kidneys Conclusion: causes acute injury, showing more nephrotoxicity. extract reduced biochemical markers of did reverse damage, suggesting potential mitigation some

Language: Английский

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