Carboxylic Acid Concentration in Downstream Bioprocessing Using High-Pressure Reverse Osmosis DOI Creative Commons
Yian Chen, Hakan Olcay, Eric C. D. Tan

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: 13(16), P. 5889 - 5905

Published: April 11, 2025

During the production of many bio-based chemicals from fermentation and enzymatic processes, product separations frequently represent most expensive energy-intensive unit operations in an integrated process, often due to low concentrations target bioproducts. In this study, we high-pressure reverse osmosis (HPRO) concentrate exemplary product, butyric acid, prior downstream extraction. Through both modeling experimental measurements, identified major factors limiting maximum achievable concentration factor (CF) 4.0 for acid with HPRO membrane compared 2.6-3.2 range conventional (RO) membranes. The resulting concentrated aqueous stream underwent liquid-liquid extraction organic solvent distillation purification recycling. integration into situ recovery (ISPR) process leads >5-fold increase final phase, a concomitant 76% reduction usage. These improvements lead estimated 53 46% ISPR cost greenhouse gas (GHG) emissions, respectively, considerably exceeding performance when integrating RO concentration. Overall, enables more economical sustainable bioproduct dilute streams.

Language: Английский

Carboxylic Acid Concentration in Downstream Bioprocessing Using High-Pressure Reverse Osmosis DOI Creative Commons
Yian Chen, Hakan Olcay, Eric C. D. Tan

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: 13(16), P. 5889 - 5905

Published: April 11, 2025

During the production of many bio-based chemicals from fermentation and enzymatic processes, product separations frequently represent most expensive energy-intensive unit operations in an integrated process, often due to low concentrations target bioproducts. In this study, we high-pressure reverse osmosis (HPRO) concentrate exemplary product, butyric acid, prior downstream extraction. Through both modeling experimental measurements, identified major factors limiting maximum achievable concentration factor (CF) 4.0 for acid with HPRO membrane compared 2.6-3.2 range conventional (RO) membranes. The resulting concentrated aqueous stream underwent liquid-liquid extraction organic solvent distillation purification recycling. integration into situ recovery (ISPR) process leads >5-fold increase final phase, a concomitant 76% reduction usage. These improvements lead estimated 53 46% ISPR cost greenhouse gas (GHG) emissions, respectively, considerably exceeding performance when integrating RO concentration. Overall, enables more economical sustainable bioproduct dilute streams.

Language: Английский

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