Acta Biotheoretica,
Journal Year:
2023,
Volume and Issue:
72(1)
Published: Dec. 27, 2023
Abstract
This
paper
focuses
on
physiological
integration
in
multicellular
systems,
a
notion
often
associated
with
biological
individuality,
but
which
has
not
received
enough
attention
and
needs
thorough
theoretical
treatment.
Broadly
speaking,
consists
how
different
components
come
together
into
cohesive
unit
they
are
dependent
one
another
for
their
existence
activity.
argues
that
can
be
understood
by
considering
the
of
system
controlled
coordinated
such
way
activities
contribute
to
maintenance
system.
The
main
implication
this
perspective
is
ways
controlling
parts
may
give
rise
organizations
degrees
integration.
After
defining
control,
analyses
control
realized
two
examples
systems
located
at
ends
spectrum
multicellularity:
biofilms
animals.
It
differences
ranges,
it
high
degree
implies
exerted
both
medium
long
insofar
as
lack
long-range
(relative
size)
considered
less
integrated
than
other
systems.
then
discusses
account
debate
individuality
idea
imply
individuality.
Ratio,
Journal Year:
2024,
Volume and Issue:
37(4), P. 327 - 340
Published: May 24, 2024
Abstract
This
paper
critically
revises
the
organisational
account
of
teleology,
which
argues
that
living
systems
are
first
and
foremost
oriented
towards
a
goal:
maintaining
their
own
conditions
existence.
It
points
out
some
limitations
this
account,
mainly
in
capability
to
for
richness
complexity
biological
purposeful
behaviours.
identifies
reason
these
theoretical
grounding
specifically
too
narrow
notion
closure
constraints,
focused
on
self‐production.
proposes
ground
an
teleology
system
not
just
produce
replace
parts,
but
control
internal
dynamics
behaviours
such
way
as
maintain
themselves.
framework
has
two
advantages.
better
captures
distinctive
features
organisations
consequently
active
nature
By
doing
so,
it
makes
possible
apply
beyond
minimal
models
real
cases.
Studies in History and Philosophy of Science Part A,
Journal Year:
2022,
Volume and Issue:
95, P. 145 - 157
Published: Aug. 24, 2022
Autoinhibition
is
a
design
principle
realized
in
many
molecular
mechanisms
biology.
After
explicating
the
notion
of
and
showing
that
autoinhibition
such
principle,
we
focus
on
how
researchers
discovered
instances
autoinhibition,
using
research
establishing
motors
kinesin
dynein
as
our
case
study.
Research
began
fashion
described
accounts
mechanistic
explanation
but,
once
had
been
discovered,
they
exhibited
second
phenomenon,
autoinhibition.
The
discovery
not
only
reverses
pattern
terms
which
philosophers
have
understood
mechanism
but
runs
counter
to
one
phenomenon-one
assumed
relate
phenomena
explain.
ubiquity
therefore,
necessitates
philosophical
understanding
recognizes
can
participate
more
than
phenomenon.
Since
with
this
are
released
from
when
acted
by
control
mechanisms,
advance
revised
account
accommodates
attribution
multiple
same
distinguishes
them
other
processes
them.
History, philosophy and theory of the life sciences,
Journal Year:
2023,
Volume and Issue:
unknown, P. 85 - 108
Published: Dec. 12, 2023
Abstract
According
to
new
mechanists,
mechanisms
explain
how
specific
biological
phenomena
are
produced.
New
mechanists
have
had
little
say
about
relate
the
organism
in
which
they
reside.
A
key
feature
of
organisms,
emphasized
by
autonomy
tradition,
is
that
organisms
maintain
themselves.
To
do
this,
rely
on
mechanisms.
But
must
be
controlled
so
produce
for
responsible
when
and
manner
needed
organism.
account
controlled,
we
characterize
as
sets
constraints
flow
free
energy.
Some
flexible
can
acted
other
mechanisms,
control
utilize
information
procured
from
its
environment
alter
appropriate
circumstances.
We
further
show
living
organized
heterarchically—control
carried
out
primarily
local
controllers
integrate
acquire
well
procure
The
result
not
a
hierarchy
but
an
integrated
network
has
been
crafted
over
course
evolution.
INTERNATIONAL NEUROLOGICAL JOURNAL,
Journal Year:
2024,
Volume and Issue:
20(3), P. 156 - 165
Published: May 29, 2024
Autonomic
disorders
predominate
or
are
present
in
most
patients
with
pathological
conditions,
especially
traumatic
and
ischemic
brain
injuries.
The
use
of
physical
factors
therapy,
electric
influence,
easily
changes
the
activity
autonomic
system,
which
adapts
body
to
external
conditions.
Of
particular
interest
is
intranasal
drug
delivery,
including
neuropeptides,
combination
influence
while
using
olfactory
pathways
central
nervous
a
number
visceral
reflexes,
neurohumoral
effects,
active
moments
galvanization
others.
conducted
clinical
experimental
studies
confirm
pathogenetic
mechanisms
peptide
compounds
their
effectiveness.
In
trauma
ischemia
rats,
administration
neuropeptides
normalized
bioelectrogenesis,
behavioral,
cognitive
activity,
neurological
deficit,
morphological
damage.
antioxidant
effect
was
separately
confirmed.
work
presents
several
authors’
techniques
for
drugs
correcting
state
cerebral
hemodynamics
case
damage
system.
positive
effects
therapy
deficits,
vascular
described.
Intranasal
delivery
system
makes
it
possible
decrease
medication
load
by
reducing
therapeutic
doses.
Thus,
presented
technique
described,
should
be
used
rehabilitation
neurology
can
“trigger”
processes
Philosophical Psychology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Dec. 6, 2024
The
scientific
investigation
of
pain
faces
many
challenges.
I
argue
that
one
the
central
challenges
posed
by
–
its
inherent
complexity
and
supposed
idiosyncrasy
is
best
understood
as
an
instance
a
more
general
issue
in
mind
sciences:
problem
psychological
integration.
This
label
not
yet
explanation
or
account
underlying
challenge,
but
rather
precise,
empirically
tractable
formulation
worry
it
arises
multiple
domains.
In
this
paper
first
lay
out
substantive
integration,
focusing
on
both
informational
regulative
aspects
coordination
control,
then
apply
conception
to
peripheral
elements
sensory
processing.
Acta Biotheoretica,
Journal Year:
2023,
Volume and Issue:
72(1)
Published: Dec. 27, 2023
Abstract
This
paper
focuses
on
physiological
integration
in
multicellular
systems,
a
notion
often
associated
with
biological
individuality,
but
which
has
not
received
enough
attention
and
needs
thorough
theoretical
treatment.
Broadly
speaking,
consists
how
different
components
come
together
into
cohesive
unit
they
are
dependent
one
another
for
their
existence
activity.
argues
that
can
be
understood
by
considering
the
of
system
controlled
coordinated
such
way
activities
contribute
to
maintenance
system.
The
main
implication
this
perspective
is
ways
controlling
parts
may
give
rise
organizations
degrees
integration.
After
defining
control,
analyses
control
realized
two
examples
systems
located
at
ends
spectrum
multicellularity:
biofilms
animals.
It
differences
ranges,
it
high
degree
implies
exerted
both
medium
long
insofar
as
lack
long-range
(relative
size)
considered
less
integrated
than
other
systems.
then
discusses
account
debate
individuality
idea
imply
individuality.
