Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology DOI Creative Commons
Vishnuram Abhinav,

Prithvi Basu,

Saurabh Verma

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(5), P. 522 - 522

Published: April 28, 2025

Wearable and implantable BioMEMSs (biomedical microelectromechanical systems) have transformed modern healthcare by enabling continuous, personalized, minimally invasive monitoring, diagnostics, therapy. advanced rapidly, encompassing a diverse range of biosensors, bioelectronic systems, drug delivery platforms, motion tracking technologies. These devices enable non-invasive, real-time monitoring biochemical, electrophysiological, biomechanical signals, offering personalized proactive solutions. In parallel, BioMEMS significantly enhanced long-term targeted delivery, neurostimulation. From continuous glucose intraocular pressure to programmable bioelectric implants for neuromodulation, these are improving precision treatment localized This review explores the materials technologies driving advancements in wearable BioMEMSs, focusing on their impact chronic disease management, cardiology, respiratory care, glaucoma treatment. We also highlight integration with artificial intelligence (AI) Internet Things (IoT), paving way smarter, data-driven Despite potential, face challenges such as regulatory complexities, global standardization, societal determinants. Looking ahead, we explore emerging directions like multifunctional biodegradable power sources, next-generation point-of-care diagnostics. Collectively, position pivotal enablers future patient-centric systems.

Language: Английский

Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics DOI Creative Commons
Hossein Omidian, Sumana Dey Chowdhury

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206

Published: March 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Language: Английский

Citations

1
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application DOI Creative Commons

Syed Waqas Ali Shah,

Xingxing Li, Hao Yuan

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Recent strides in non‐invasive drug delivery have spurred innovation alternatives to traditional needle injections. Transdermal systems (TDDs) emerged as a particularly promising avenue, boasting minimal rejection rates, user‐friendly administration, and enhanced patient adherence. Beyond pharmaceuticals, TDDs show potential skincare cosmetics, leveraging their ability facilitate localized while minimizing systemic exposure. Nonetheless, the intricate physicochemical nature of skin presents formidable obstacles, prompting intensive exploration overcome these barriers. This comprehensive review delves into landscape methodologies, critically analyzing respective advantages, limitations, characterization prospective applications. advancements underscore robust efficacy TDDs, positioning it versatile indispensable modality poised for widespread integration across multifarious fields.

Language: Английский

Citations

0
Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review DOI Creative Commons

Manuel R Pouso,

Bruna L. Melo,

Joaquim J Gonçalves

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125640 - 125640

Published: April 1, 2025

Multiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, outcome regimens remains impaired by drugs' weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered development nanomaterials encapsulate deliver anticancer drugs. In fact, loading drugs into nanoparticles can overcome most solubility concerns. However, ability systemically administered drug-loaded reach site has vastly overestimated, limiting their clinical translation. The nanomaterials' administration issues propelled hydrogels capable performing direct/local delivery site. use these macroscale systems mediate a tumor-confined drugs/drugs-loaded grants an improved therapeutic efficacy and, simultaneously, reduction side effects. manufacture requires careful selection tailoring specific polymers/materials as well choice appropriate physical and/or chemical crosslinking interactions. Depending on route assembling process, matrices be classified injectable in situ forming hydrogels, shear-thinning/self-healing implantable each type bringing plethora advantages for intended biomedical application. This review provides reader with insight application nanomaterials.

Language: Английский

Citations

0
Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology DOI Creative Commons
Vishnuram Abhinav,

Prithvi Basu,

Saurabh Verma

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(5), P. 522 - 522

Published: April 28, 2025

Wearable and implantable BioMEMSs (biomedical microelectromechanical systems) have transformed modern healthcare by enabling continuous, personalized, minimally invasive monitoring, diagnostics, therapy. advanced rapidly, encompassing a diverse range of biosensors, bioelectronic systems, drug delivery platforms, motion tracking technologies. These devices enable non-invasive, real-time monitoring biochemical, electrophysiological, biomechanical signals, offering personalized proactive solutions. In parallel, BioMEMS significantly enhanced long-term targeted delivery, neurostimulation. From continuous glucose intraocular pressure to programmable bioelectric implants for neuromodulation, these are improving precision treatment localized This review explores the materials technologies driving advancements in wearable BioMEMSs, focusing on their impact chronic disease management, cardiology, respiratory care, glaucoma treatment. We also highlight integration with artificial intelligence (AI) Internet Things (IoT), paving way smarter, data-driven Despite potential, face challenges such as regulatory complexities, global standardization, societal determinants. Looking ahead, we explore emerging directions like multifunctional biodegradable power sources, next-generation point-of-care diagnostics. Collectively, position pivotal enablers future patient-centric systems.

Language: Английский

Citations

0