Evaluation of the effect of COVID-19 infection in pregnancy and puerperium in a suburban medical college in West Bengal, India

Journal of Family Medicine and Primary Care, Journal Year: 2024, Volume and Issue: 13(6), P. 2404 - 2409

Published: June 1, 2024

A BSTRACT Background: The pandemic of SARS-CoV-2 was a novel situation, there no conclusive knowledge, particularly concerning its effect on pregnant women and infants. Eminent obstetric organizations have introduced an array guidelines to assist clinicians in countering this prior unknown outbreak. primary objective study summarize the clinical characteristics, complications, maternal neonatal outcomes COVID-19 during pregnancy puerperium. Methods: This cross-sectional observational conducted Outpatient/Emergency/Inpatient or COVID ward Department Obstetrics Gynaecology, tertiary hospital Nadia district, West Bengal, India, from 1.7.2020 30.6.2021 including 104 puerperal mothers with laboratory-confirmed, i.e., RT-PCR Rapid Antigen Test positive reports after informed consent. outcome, modes delivery, status any complications SNCU admission within six weeks postpartum were recorded. Results: majority ≥ 20–24 years age group, primigravida, residents significant travel contact history. 73.08% affected third trimester comorbidities detected chiefly anemia (15.38%), hypertensive chronic liver diseases, hypothyroidism. 45.19% asymptomatic while other complaints fever (18.27%), cough (11.55%), anosmia and/or ageusia (10.58%), sore throat (9.61%), respiratory distress, loose stools, chest pain. medical predominantly low SpO2, convulsions, pneumonitis, two deaths. preterm birth (26.9%), pre-eclampsia/eclampsia (17.3%), antepartum (3.9%) hemorrhage (4.4%), sepsis (5.8%). Fourteen had first-trimester termination, 63 vaginal deliveries, rest cesarean section. Out 90 neonates, most range 2–2.5 kg weight normal 1-min APGAR score. None tested for RTPCR detectable congenital anomaly death

Language: Английский

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Evaluation of the effect of SARS-COV-2 infection on Doppler ultrasound and placental findings of pregnant women: A systematic review and meta-analysis.

ULTRASONOGRAPHY, Journal Year: 2024, Volume and Issue: 43(6), P. 424 - 437

Published: July 15, 2024

Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the human placenta and has been shown to have an adverse effect on Doppler ultrasound parameters placental features. However, specific effects of SAS-CoV-2 infection fetal-placental unit in pregnant women remain unclear. The aim this systematic review meta-analysis was evaluate impact SARS-CoV-2 findings women.Methods: A search conducted using four electronic databases (PubMed, Embase, Scopus, Cochrane Library) select publications published peer-reviewed journals written English. Odds ratios (ORs) were calculated, along with their 95% confidence intervals (CIs). Heterogeneity assessed Q I2 statistics appropriate P-value. analysis used RevMan 5.3.Results: This included 1,210 from 10 case-control studies. SARS-CoV-2–infected exhibited higher likelihoods abnormalities (OR, 2.62; CI, 1.66 4.13), aberrant values 1.95; 1.16 3.27), abnormal cerebroplacental ratio 2.68; 1.52 4.75), altered fetoplacental circulation 1.56; 1.07 2.28), increased thickness venous lakes 1.85; 1.25 2.72).Conclusion: According meta-analysis, infected are more likely experience ultrasonography abnormalities, including thickness, lakes, circulation, ratio. limited number studies requires larger sample sizes validate enhance evidence.

Language: Английский

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No impact of COVID-19 at delivery on maternal mortality or infant adverse birth outcomes in Botswana during the Omicron era

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0310980 - e0310980

Published: Sept. 25, 2024

SARS-CoV-2 infection during pregnancy was associated with maternal mortality and adverse birth outcomes in the pre-Omicron era, including a stillbirth rate of 5.6% Botswana. We re-evaluated these Tsepamo Study Omicron era. assessed for all singleton pregnancies from mid-November 2021 (the start era) to mid-August 2022 at nine sites, among individuals documented screening PCR or antigen tests known HIV status. Of 9,705 women routinely screened delivery (64% deliveries sites), 373 (3.8%) tested positive. Women were as likely test positive (77/1833, 4.2%) without (293/6981, (p = 1.0). There 5 recorded deaths (0.03%), one occurring woman result. In contrast, 3.7% 0.1% those SARS-CoV-2, respectively, there no differences infants exposed unexposed overall (28.1% vs 29.6%; aRR 1.0, 95%CI 0.8–1.1), severe (11.9 10.6%; 1.1, 0.8–1.5), preterm (15.1% 14.9%; 0.8–1.3), (1.9% 2.3%; 0.8, 0.4–1.7). Adverse both similar alone (31.2% vs. 33.1%; 0.9, 0.6–1.3; p 0.5). Maternal far lower Botswana era than longer significantly impacted by exposure either co-exposure. Increased population immunity less stress on hospital systems possible viral pathogenicity may combine explain findings.

Language: Английский

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COVID-19 in pregnancy: prevalence, management, and outcomes in a single large health system

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2024, Volume and Issue: 37(1)

Published: Jan. 2, 2024

This study assessed the prevalence of SARS-CoV-2 positivity in a cohort pregnant patients served by single health system. Treatments and outcomes are compared maternal status COVID-19 symptomatology.

Language: Английский

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Impact of COVID-19 in pregnancy on maternal and perinatal outcomes during the Delta variant period: a comparison of the Delta and pre-delta time periods, 2020–2021

Maternal Health Neonatology and Perinatology, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 30, 2024

Language: Английский

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Maternal infection with SARS‐CoV‐2 during early pregnancy induces hypoxia at the maternal–fetal interface

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract The coronavirus disease 2019 (COVID‐19) pandemic increases the risk of adverse fetal outcomes during pregnancy. Maternal infection pregnancy, particularly with cytomegalovirus (CMV), hepatitis B and C virus, human immunodeficiency virus can have detrimental effects on both mother fetus, potentially leading to such as spontaneous abortion or neonatal infection. However, impact severe acute respiratory syndrome (SARS‐CoV‐2) maternal–fetal interface remains poorly understood. In this study, we initially utilised immunofluorescence immunohistochemical investigate placental samples from pregnant women who were infected SARS‐CoV‐2 first trimester. Our data indicate that in trimester induces an upregulation hypoxia inducible factor (HIF) levels at interface. Subsequently, single‐cell RNA sequencing metabolomics analyses reveal alterations Remarkably, immune cells exhibited low expression HIF possibly associated activation. Furthermore, our findings demonstrate a gradual reduction transcriptome metabolic changes gestation progressed beyond 12–16 weeks compared obtained 6–8 gestation. Overall, study suggests early‐stage leads aberrant cell metabolism which gradually resolves pregnancy progresses. Nevertheless, these abnormal may long‐term implications for development.

Language: Английский

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Impact of the COVID-19 pandemic on maternal, neonatal and child health service utilisation, delivery and health outcomes in Gauteng province, South Africa: an interrupted time series (ITS) analysis

BMJ Open, Journal Year: 2024, Volume and Issue: 14(10), P. e090645 - e090645

Published: Oct. 1, 2024

Gauteng was one of the provinces in South Africa most hit by COVID-19. However, there has been no assessment pandemic's impact on essential maternal, neonatal and child health (MNCH) services Gauteng, for planning against future emergencies. This study sought to assess COVID-19 pandemic MNCH service utilisation, delivery outcomes province.

Language: Английский

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Metabolic processes of prostaglandin metabolism in women at 28–30 weeks of gestation with COVID-19

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2024, Volume and Issue: 9(5), P. 34 - 42

Published: Nov. 21, 2024

Background . COVID-19 negatively impacts pregnancy progression and outcomes. However, data regarding complications related to prostaglandin activity during remain insufficient. The aim To assess markers of metabolic processes metabolism in the blood pregnant women depending on severity explore associations with development complications. Methods study included 109 their third trimester (28–30 weeks), 36 whom had mild COVID-19, 38 moderate 35 were not infected SARS-CoV-2. concentration prostaglandins E2 F2α, phospholipase A2 (PLA2), cyclooxygenase 2 (COX2), arachidonic acid (AA) measured using enzyme-linked immunosorbent assays gasliquid chromatography for AA. Results Comparative analysis showed that significantly higher levels AA, COX2, PLA2, F2α (p < 0.0001) compared those disease. These also experienced more frequent complications, such as chronic placental insufficiency, preterm labor, premature rupture membranes. Regression revealed between insufficiency 0.0001), AA = 0.001) COX2 0.001); membranes PLA2 0.025), 0.001), 0.001). Conclusion Moderate is associated increased blood. most significant factors increasing risk elevated

Language: Английский

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Maternal and perinatal COVID-19 – The past, present and the future

Seminars in Fetal and Neonatal Medicine, Journal Year: 2023, Volume and Issue: 28(1), P. 101434 - 101434

Published: Feb. 1, 2023

Language: Английский

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