Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 17, 2025
The
aim
of
this
study
was
to
investigate
the
causal
relationship
between
microbiota,
diabetic
nephropathy,
and
blood
metabolites
through
a
randomized
Mendelian
study.
In
study,
we
used
412
microbiota
as
exposures,
1,400
intermediaries,
nephropathy
outcome.
We
conducted
two-way
randomization
(MR)
analysis
explore
followed
by
mediation
analyses
two-step
MR
identify
potential
metabolites.
There
is
nephropathy.
Specific
bacteria
metabolites,
such
Escherichia
coli
str.
K-12
substr.
MG1655,
Listeria
monocytogenes
10403S,
g_Adlercreutzia,
g_Haemophilus,
g_Bacteroides,
CFT073,
like
pyrraline,
glycocholenate
sulfate,
alpha-ketoglutarate,
tetradecadienoate
(14:2),
Cys-gly
oxidized,
methylsuccinate,
various
others,
were
identified.
MG1655
positively
related
alpha-ketoglutarate
levels,
while
levels
Sphingomyelin
(d18:1/18:1,
d18:2/18:0)
are
negatively
related.
bacterial
involved
in
fatty
acid
oxidation
associated
with
kidney
disease
(DKD)
progression,
correlated
sulfate
phosphate
linoleyl-tetraenyl-glycerol
(18:2
20:4)
ratio.
Additionally,
10403S
N-acetyl-isoputreanine
X-12462.
Anaerobic
fermentation-related
N-acetylcarnitine
5-acetylamino-6-formyluracil
5-acetamino-6-amino-3-methyluracil
(X-24243).
CFT073
X-16580.
Interactions
Bacillus
species
d18:1/18:1,
d18:2/18:0,
2-aminophenol
cholate
negative
when
compared
(14:2).
g_Adlercreutzia
N-delta-acetylornithine,
but
N-acetylglucosamine
N-acetylgalactosamine.
g_Haemophilus
arachidoylcarnitine
X-24531.
results
heterogeneous
multi-efficacious.
For
first
time,
provides
supportive
evidence
for
bidirectional
identifies
specific
genes
disease.
suggest
that
probiotic
therapy
may
play
significant
role
preventing
improving
quality
life
survival
rates
affected
patients.
Furthermore,
additional
Language: Английский
The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9244 - 9244
Published: Aug. 26, 2024
Lipid
disorders
increase
the
risk
for
development
of
cardiometabolic
disorders,
including
type
2
diabetes,
atherosclerosis,
and
cardiovascular
disease.
Lipids
levels,
apart
from
diet,
smoking,
obesity,
alcohol
consumption,
lack
exercise,
are
also
influenced
by
genetic
factors.
Recent
studies
suggested
role
long
noncoding
RNAs
(lncRNAs)
in
regulation
lipid
formation
metabolism.
Despite
their
protein-coding
capacity,
lncRNAs
crucial
regulators
various
physiological
pathological
processes
since
they
affect
transcription
epigenetic
chromatin
remodelling.
LncRNAs
act
as
molecular
signal,
scaffold,
decoy,
enhancer,
guide
molecules.
This
review
summarises
available
data
concerning
impact
on
levels
metabolism,
well
disease
risk.
relationship
is
significant
because
altered
metabolism
a
well-known
factor
diseases,
may
play
regulatory
role.
Understanding
these
mechanisms
could
pave
way
new
therapeutic
strategies
to
mitigate
through
targeted
modulation
lncRNAs.
The
identification
dysregulated
pose
promising
candidates
interventions,
enabling
restoration
offer
an
effective
means
impede
progression
without
disrupting
normal
biological
functions.
serve
valuable
biomarker
states,
However,
still
much
remains
unknown
about
functions
most
lncRNAs,
thus
extensive
necessary
elucidate
roles
physiology,
development,
Language: Английский