Flavonoids as Natural Anti-Inflammatory Agents in the Atopic Dermatitis Treatment

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 261 - 261

Published: Feb. 15, 2025

Eczema is a complex autoimmune condition characterised mainly by inflammation and skin lesions along with physical psychological comorbidities. Although there have been significant advances in understanding the mechanisms behind atopic dermatitis, conventionally available treatments yield inconsistent results some unintended consequences. In today's digital age, where knowledge just click away, natural-based supplements on rise for more "natural" treatment towards any type of disease. Natural compounds, particularly derived from medicinal plants, piqued interest development herbal remedies chronic inflammatory conditions. Among many flavonoids shown promise treating eczema due to their strong anti-inflammatory, antioxidant, anti-allergic properties, making them helpful preventing allergic reactions, inflammation, irritation. This review highlights therapeutic potential flavonoid-based bioactive compounds manage eczema, emphasising action. Additionally, providing comprehensive analysis emerging established while bridging gap between traditional modern medicine. Flavonoids offer variety opportunities further research innovative formulations that can maximise its full benefits. Further combination various approaches such as nanoencapsulation enhanced bioavailability, hydrogel-based delivery systems controlled release, additive manufacturing personalised topical formulations, could align future precision medicine needs.

Language: Английский

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Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel

Polymers, Journal Year: 2024, Volume and Issue: 16(16), P. 2368 - 2368

Published: Aug. 21, 2024

In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis CS/CMCD subsequent loading BBH into composite (CS/CMCD/BBH) effectively accomplished. used as model drug resulting demonstrated sustained release profile. addition to its improved solubility characteristics, exhibited excellent antibacterial activity against common pathogens such Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Candida albicans (C. albicans). Additionally, in vitro studies indicated that not cytotoxic NIH3T3 HaCaT cells, suggesting safety for biomedical applications. This lack effects, combined with mechanical strength, improvements, properties hydrogel, positions CS/CMCD/BBH promising candidate effective delivery BBH. By addressing challenges BBH, offers viable solution administration potential applications various fields.

Language: Английский

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Berberine Intervention Mitigates Myocardial Ischemia-Reperfusion Injury in a Rat Model: Mechanistic Insights via miR-184 Signaling

Biologics, Journal Year: 2025, Volume and Issue: Volume 19, P. 31 - 42

Published: Feb. 1, 2025

Ischemia-reperfusion (I/R) injury is a major contributor to myocardial dysfunction and tissue damage. A natural alkaloid-Berberine having wide range of pharmacological properties, has garnered interest for its potential cardioprotective properties. This study aimed investigate the protective effects berberine on in rat model ischemia-reperfusion injury. Additionally, explored role miR-184/NOTCH1 signaling pathway mediating these effects. Male Wistar rats were randomly assigned five groups: sham-operated control, I/R injury, treated with berberine, inhibitor NC miR-184 inhibitor. The was induced by ligating left anterior descending (LAD) coronary artery 30 minutes, followed 2 hours reperfusion. Berberine administered orally at 100 mg/kg/day weeks, via intraperitoneal injection. Hemodynamic parameters recorded using pressure sensor connected catheter inserted into ventricle. Myocardial infarct size assessed TTC staining, while histological molecular changes evaluated through H&E TUNEL assay, Western blotting. expression levels target genes analyzed quantitative real-time PCR (qRT-PCR). significantly reduced improved hemodynamic compared untreated group. treatment attenuated apoptosis as evidenced decreased TUNEL-positive cells. also demonstrated modulating key pathways involved blot analysis revealed downregulation NOTCH1 HES1 groups, indicating mechanism observed cardio protection. inhibition offer significant protection against These findings suggest that targeting associated may be promising therapeutic strategy reducing cardiac damage following ischemia-reperfusion.

Language: Английский

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Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel

Published: July 22, 2024

In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis CS/CMCD subsequent loading BBH into composite (CS/CMCD/BBH) effectively accomplished. used as model drug resulting demonstrated sustained release profile. addition to its improved solubility characteristics, exhibited excellent antibacterial activity against common pathogens such Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Candida albicans (C. albicans). Additionally, in vitro studies indicated that not cytotoxic NIH3T3 HaCaT cells, suggesting safety for biomedical applications. This lack effects, combined with mechanical strength, improvements, properties hydrogel, positions CS/CMCD/BBH promising candidate effective delivery BBH. By addressing challenges BBH, offers viable solution administration hydrochloride, potential applications various fields.

Language: Английский

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Oxidative Stress and Erectile Dysfunction

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 2514 - 2518

Published: Jan. 1, 2024

Language: Английский

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Unraveling the molecular dissociation between aging and atherosclerosis: A bioinformatics approach

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Aim In clinical practice, cardiologists frequently note substantial differences in coronary artery health among patients of the same age bracket. This observation led to our investigation into identifying genes that are shared between atherosclerosis and aging, as well those specifically amplified alone. Methods Our study leveraged existing gene expression datasets from Gene Expression Omnibus (GEO), avoiding need for new experimental research involving human or animal subjects. We focused on analyzing two specific datasets: one comprising samples individuals with without atherosclerosis, other featuring people middle versus older groups. To identify significant genes, we applied a technique known weighted average difference (WAD). Results analysis identified 14 were upregulated both aging hinting at involvement type I interferon response conditions. Conversely, 408 exhibited heightened activity within atherosclerotic lesions indicated an augmentation lysosome‐related processes. While might create groundwork predisposes progression also involves distinct factors such increase lysosomal activity. Conclusions Aging encompasses more than just senescence vascular cells; it is significantly affected by extracellular interferon. The onset therefore, cannot be attributed solely aging. Instead, likely enhanced mechanisms phagocytosis heighted Geriatr Gerontol Int 2024; ••: ••–•• .

Language: Английский

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The association between comprehensive dietary antioxidant index and erectile dysfunction in adult men: a cross-sectional study from the 2001-2004 U.S. National Health and Nutrition Examination Survey

Sexual Medicine, Journal Year: 2024, Volume and Issue: 12(6)

Published: Dec. 1, 2024

Language: Английский

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