Analysis of clinical indicators and survival prediction in trauma patients

Technology and Health Care, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Accurate prognostic assessment of critically ill trauma patients in emergency departments is crucial for early intervention and improving survival rates. This study investigates the relationship between blood parameters, disease severity, patient outcomes. To explore parameters severity prognosis an center. The goal to facilitate diagnosis, implement measures improve rates, enhance retrospective analyzed 569 admitted center from 2020 August 2023. analysis focused on examining these patients. Compared improved non-recovered groups, mortality group had longer times injury hospital admission, higher ISS NEWS scores, lower GCS more acidic gas analysis, electrolyte imbalances, poorer liver kidney function as well coagulation indicators. Low pH, high PaCO2, lactate, potassium, NLR, D-Dimer, ISS, are independent risk factors. Conversely, PLT, albumin, scores protective These indicators can effectively predict

Language: Английский

Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: a retrospective study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 21, 2025

Abstract Sepsis after trauma and trauma-induced SIRS have similar symptoms, making their differentiation challenging. Therefore, biomarkers are needed to differentiate between sepsis SIRS. We hypothesized that following induces distinct alterations in blood metabolism compared sought identify metabolite could the two. In this retrospective study, existing metabolomics data from 60 patients without SIRS, 40 with 50 non-trauma control cases were analyzed. Among traumatic 16 developed (SDS group), 24 did not develop (SDDS group) within subsequent two-week period trauma. A pairwise comparison SDS group SDDS was used screen differential metabolites as distinguishing Using partial least‑squares discriminant analysis, we demonstrated metabolically group. total of 37 found selected 5 most significantly different groups discriminate which 7-alpha-carboxy-17-alpha-carboxyethylandrostan lactone phenyl ester, docosatrienoic acid, SM 8:1;2O/26:1, 34:2;2O, N1-[1-(3-isopropenylphenyl)-1-methylethyl]-3-oxobutanamide. Our study has identified potential these for differentiating This only provides a new approach early diagnosis but also lays solid foundation further research based on targeted metabolomics, may lead development more effective treatment strategies future.

Language: Английский

Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: A retrospective study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Background Sepsis after trauma and trauma-induced SIRS may present with similar symptoms, so it is a great challenge to distinguish sepsis from SIRS. Besides, uncovers the occurrence of trauma. Thus, there need for biomarkers them. We hypothesized that leads different changes in blood metabolism than searched metabolite between two conditions. Methods This study retrospectively analyzed existing metabonomics data patients severe (100 cases), (50 non-trauma controls cases). screened out 40 100 then used pairwise comparison screen differential metabolites as distinguishing Results In total, 413 could differentiate Using partial least‑squares discriminant analysis, we showed was metabolically distinct The main were LPC O-22:1, uric acid, 23-Norcholic PC O-38:1, O-42:3 (AUC: 0.875 0.910). Conclusions Our has identified potential employing metabolic differentiation particular, demonstrated important These provide basis further research on identifying based targeted metabolomics.

Language: Английский