Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 175 - 175

Published: Jan. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Language: Английский

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Obesity is associated with severe disease and mortality in patients with coronavirus disease 2019 (COVID-19): a meta-analysis

BMC Public Health, Journal Year: 2021, Volume and Issue: 21(1)

Published: Aug. 4, 2021

The coronavirus disease 2019 (COVID-19) pandemic has led to global research predict those who are at greatest risk of developing severe and mortality. aim this meta-analysis was determine the associations between obesity severity mortality due COVID-19.We searched PubMed, EMBASE, Cochrane Library Web Science databases for studies evaluating with COVID-19. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Meta-regression analyses conducted estimate regression coefficients.Forty-six involving 625,153 patients included. Compared nonobese patients, obese had a significantly increased infection. (OR 2.73, CI 1.53-4.87; I2 = 96.8%), hospitalization 1.72, 1.55-1.92; 47.4%), clinically 3.81, 1.97-7.35; 57.4%), mechanical ventilation 1.66, 1.42-1.94; 41.3%), intensive care unit (ICU) admission 2.25, 1.55-3.27; 71.5%), 1.61, 1.29-2.01; 83.1%).Patients may have greater infection, hospitalization, disease, ventilation, ICU admission, Therefore, it is important increase awareness these in COVID-19 patients.

Language: Английский

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Short and Long-Term Impact of COVID-19 Infection on Previous Respiratory Diseases

Archivos de Bronconeumología, Journal Year: 2022, Volume and Issue: 58, P. 39 - 50

Published: April 1, 2022

Language: Английский

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Pre-admission glucagon-like peptide-1 receptor agonist (GLP-1RA) and mortality from coronavirus disease 2019 (Covid-19): A systematic review, meta-analysis, and meta-regression

Diabetes Research and Clinical Practice, Journal Year: 2021, Volume and Issue: 179, P. 109031 - 109031

Published: Aug. 28, 2021

GLP-1RA has many beneficial properties, including anti-inflammatory, anti-obesogenic, pulmonary protective effects as well impact on gut microbiome. However, the evidence regarding benefit of in Covid-19 patients with diabetes is still unclear. This study sought to analyze pre-admission use altering mortality outcomes coronavirus disease 2019 (Covid-19) mellitus.Using specific keywords, we comprehensively searched potential articles PubMed, Europe PMC, and medRxiv database until June 12th, 2021. All published studies were retrieved. Statistical analysis was conducted using Review Manager 5.4 Comprehensive Meta-Analysis version 3 software.A total 9 19,660 mellitus who infected by SARS-CoV-2 included meta-analysis. Our data suggested that associated reduction rate from (OR 0.53; 95 %CI: 0.43-0.66, p < 0.00001, I2 = 0%, random-effect modelling). Further showed associations not influenced age (p 0.213), gender 0.421), hypertension 0.131), cardiovascular 0.293), nor metformin 0.189) insulin 0.117).Our suggests may offer mellitus. more randomized clinical trials are required confirm this conclusion.

Language: Английский

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Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(11), P. e0259822 - e0259822

Published: Nov. 12, 2021

Background Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic clinical factors, particularly baseline chronic conditions, associated an increased risk of severity in from a population-based perspective using data electronic health records (EHR). Methods Retrospective, observational study open cohort analyzing all 68,913 individuals (mean 44.4 years, 53.2% women) SARS-CoV-2 infection between 15 June 19 December 2020 exhaustive registries. Patients were followed for 30 days inclusion or until date death within that period. performed multivariate logistic regression analyze association each disease severe infection, based on hospitalization all-cause mortality. Results 5885 (8.5%) showed old was most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), renal (1.31, 1.22) obesity (1.21, 1.26) likelihood both sexes. Chronic skin ulcers (1.32), acute cerebrovascular (1.34), obstructive pulmonary (1.21), urinary incontinence (1.17) neoplasms (1.26) men, infertility (1.87), sleep apnea (1.43), hepatic steatosis rheumatoid arthritis (1.39) menstrual disorders (1.18) women also more outcomes. Conclusions Age specific cardiovascular metabolic diseases infections men women, whereas effects certain comorbidities are sex specific. Future studies different settings encouraged which profiles at higher poor prognosis should therefore be targets prevention shielding strategies.

Language: Английский

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Sleep Dysfunction in COVID-19 Patients: Prevalence, Risk Factors, Mechanisms, and Management

Journal of Personalized Medicine, Journal Year: 2021, Volume and Issue: 11(11), P. 1203 - 1203

Published: Nov. 14, 2021

During the COVID-19 pandemic, need to establish prevalence of sleep dysfunction and psychological distress, identify predisposing protective factors, explore effective management strategies remains an important priority. Evidence date suggests that a considerable proportion patients experience significant disturbances (estimated afflict up 50–75%) as well distress such depression, anxiety, traumatic stress. Duration hospitalization, pre-existing mental health concerns, lower absolute lymphocyte count, increased neutrophil-to-lymphocyte ratio have been all associated with greater risk in infected hospitalized patients. Furthermore, this review, we discuss link between deprivation, susceptibility viral infections, psychosocial wellbeing relevance summarize existing evidence regarding presence role apnea individuals. Finally, highlight importance suitable interventions order prevent manage avoid long-term physical implications. Future research should aim provide high-quality information including high risk, underserved, or difficult reach populations on consequences effectiveness applied interventions.

Language: Английский

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Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression

General Hospital Psychiatry, Journal Year: 2022, Volume and Issue: 75, P. 61 - 67

Published: Feb. 4, 2022

Language: Английский

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Coronavirus disease 2019 (Covid-19) outcomes in patients with sarcopenia: A meta-analysis and meta-regression

Clinical Nutrition ESPEN, Journal Year: 2022, Volume and Issue: 48, P. 158 - 166

Published: Jan. 24, 2022

Language: Английский

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Effect of ferritin, INR, and D-dimer immunological parameters levels as predictors of COVID-19 mortality: A strong prediction with the decision trees

Heliyon, Journal Year: 2023, Volume and Issue: 9(3), P. e14015 - e14015

Published: March 1, 2023

Background and objectiveA hyperinflammatory environment is thought to be the distinctive characteristic of COVID-19 infection an important mediator morbidity. This study aimed determine effect other immunological parameter levels, especially ferritin, as a predictor mortality via decision-trees analysis.Material methodThis retrospective evaluating total 2568 patients who died (n = 232) recovered 2336) from in August December 2021. Immunological laboratory data were compared between two groups that with COVID-19. In addition, decision trees machine learning models used evaluate performance parameters disease.ResultsNon-surviving had 1.75 times higher 10.7 CRP, 2.4 D-dimer, 1.14 international-normalized-ratio (INR), 1.1 Fibrinogen, 22.9 procalcitonin, 3.35 troponin, 2.77 mm/h erythrocyte-sedimentation-rate (ESR), 1.13sec longer prothrombin time (PT) when surviving patients. our interpretable tree, which was constructed only cut-off values INR, correctly predicted 99.7% 92.7% non-surviving patients.ConclusionsThis perfectly tree INR ferritin. For this reason, we think it may include D-dimer their scoring systems planned for mortality.

Language: Английский

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Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health record-based analysis from the RECOVER initiative

SLEEP, Journal Year: 2023, Volume and Issue: 46(9)

Published: May 11, 2023

Abstract Study Objectives Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC). Methods the impact preexisting on probable PASC in adults and children using electronic health record data from multiple research networks. Three networks within REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, National Cohort Collaborative [N3C]) employed harmonized analytic approach examine COVID-19-positive patients without diagnosis prior pandemic onset. Unadjusted odds ratios (ORs) were calculated well ORs adjusted age group, sex, race/ethnicity, hospitalization status, obesity, comorbidities. Results Across networks, unadjusted OR ranged 1.41 3.93. Adjusted analyses found an attenuated association that remained significant among only. Multiple sensitivity expanded inclusion criteria covariates yielded results consistent primary analysis. Conclusions Adults have significantly elevated PASC. This finding was across sources, approaches identifying patients, definitions Patients may be at after infection should monitored post-acute sequelae.

Language: Английский

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