The causal relationship of type 1 diabetes and its complications on ingrown nails: Insights from a multivariable Mendelian randomization study

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41719 - e41719

Published: March 14, 2025

Diabetic patients often experience ingrown nails. Nevertheless, the causal relationship between different types of diabetes, their complications, and occurrence nails has yet to be fully clarified. We utilized single nucleotide polymorphisms as instrumental variables for exposure performed Mendelian randomization (MR) analysis ascertain diabetes Databases were represented through 3 categories: type 1 with or without 2 encompassing a cohort 1,575,134 individuals European descent. Following our MR results, we determined overall effect size linkage related its complications. Type had been shown increase risk an odds ratio 1.09 (95% confidence interval: 1.05-1.12; P < .001). The results demonstrated complications nails, revealing distinct ratios. In contrast, findings indicated absence specific All sensitivity analyses have proven validity reliability results. This study indicates that are more likely develop nail compared those without. Compared who get nail. Meanwhile, current data do not support

Language: Английский

Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2024, Volume and Issue: 34(1), P. 108136 - 108136

Published: Nov. 12, 2024

To determine the effect of sodium-glucose cotransporter protein 2 (SGLT2) inhibition on ischemic stroke (IS) and investigate circulating proteins that mediate effects SGLT2 IS.

Language: Английский