Morin-Based Nanoparticles for Regulation of Blood Glucose DOI

Ziqi Hua,

Yanfei Li, Tao Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21400 - 21414

Published: April 19, 2024

Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid limited bioavailability, rapid clearance in vivo hinder application regulation. To address these limitations, we report enzymatically synthesized nanosized morin particle (MNs) encapsulated sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency therapeutic efficacy Utilizing horseradish peroxidase, MNs averaging 305.7 ± 88.7 nm size. These were then via electrohydrodynamic microdroplet spraying to form M@SA microgels. In studies revealed that demonstrated prolonged intestinal retention superior compared with unmodified alone. Moreover, notably improved uptake HepG2 cells. Furthermore, effectively regulated glucose, profiles, oxidative stress diabetic mice while mitigating liver, kidney, pancreatic damage enhancing responses. Our findings propose promising strategy for the oral administration natural compounds regulation, implications broader applications.

Language: Английский

Microfluidic development of brain-derived neurotrophic factor loaded solid lipid nanoparticles: An in vitro evaluation in the post-traumatic brain injury neuroinflammation model DOI Creative Commons
Federica Sommonte, Ilaria Arduino, Rosa Maria Iacobazzi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105699 - 105699

Published: April 22, 2024

Microfluidic-based nanoscale drug delivery systems have risen to prominence in the field of precision nanomedicine recent years. This intriguing innovation could provide unique therapeutic prospects treatment serious disorders as traumatic brain injury, a potentially fatal condition that is widespread during childhood. According current scientific study, neurotrophins are vital for healing injured parenchyma, and brain-derived neurotrophic factor (BDNF) particular may significant regenerative effects. To address BDNF-related pharmacokinetic constraints, microfluidic-assisted manufacturing BDNF-loaded solid lipid nanoparticles (BDNF-SLNs) was carried out, following evaluation, formulation demonstrated optimum characteristics terms size (190.3 ± 10.1 nm), PDI (0.180 0.023), ζ-potential (– 39.2 1.30 mV). Short-term stability studies haemolysis assay verified formulation's biocompatibility, while an vitro permeability analysis revealed increase Papp encapsulated BDNF (1.27x10-5 cm/sec) compared plain (9.31x10-6 cm/sec). The mimicked neuroinflammatory model enhanced decrease nitrite production Nos mRNA levels using BDNF-SLNs control, validating proficiency microfluidic-based pioneering valuable approaches biologicals.

Language: Английский

Citations

6
A Versatile Nanocarrier—Cubosomes, Characterization, and Applications DOI Creative Commons
Cristiana Oliveira, Celso J. O. Ferreira, Miguel Rocha de Sousa

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2224 - 2224

Published: June 29, 2022

The impact of nanotechnology on the exponential growth several research areas, particularly nanomedicine, is undeniable. ability to deliver active molecules desired site could significantly improve efficiency medical treatments. One nanocarriers developed which has drawn researchers' attention are cubosomes, nanosized dispersions lipid bicontinuous cubic phases in water, consisting a lipidic interior and aqueous domains folded lattice. They stand out due their incorporate hydrophobic, hydrophilic, amphiphilic compounds, tortuous internal configuration that provides sustained release, capacity protect safely molecules. Several approaches can be taken prepare this structure, as well different lipids like monoolein or phytantriol. This review paper describes methods nanocarriers. As it known, physicochemical properties very important, they influence pharmacokinetics Therefore, an extensive characterization essential obtain effect. result, we have extensively described most common techniques characterize exceptional cubosomes make them suitable used applications biomedical field, from cancer therapeutics imaging, will described. Taking consideration outstanding application fields envisaged.

Language: Английский

Citations

27
Self-Assembled Phytochemical Nanomedicines with Enhanced Bioactivities for Effective Acute Kidney Injury Therapy DOI
Xiangyu Chen, Qian Ren, Guangcan Chen

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(19), P. 7288 - 7300

Published: April 24, 2023

Acute kidney injury (AKI) is a common and lethal complication for inpatients in the intensive care unit. Accumulative evidence suggests that severe inflammation oxidative stress are major causes of AKI. Natural polyphenols with potent antioxidative anti-inflammation activities promising treatment AKI, but low bioavailability reduces their therapeutic efficacy vivo. Herein, we reported novel polyphenol-based nanomedicine comprising tea polyphenol nanocarrier insoluble small-molecule drug curcumin targeted sepsis-induced AKI therapy. Tea nanoparticles (TP-NPs) were synthesized oligomers, then curcumin-containing (Cur-NPs) prepared by loading into TP-NPs. In vitro experiments proved capability Cur-NPs to scavenge free radicals, protect normal cells from damage, suppress expression proinflammatory factors. Furthermore, these nanomedicines effectively alleviated septic suppressing response restoring oxidant-redox homeostasis The further exhibited carrier-enhanced due effects inornate conclusion, phytochemical provide an attractive strategy therapy herald prospective future development natural reproducible resource-derived various diseases related inflammation.

Language: Английский

Citations

14
Selenium Nanoparticles as Potential Drug-Delivery Systems for the Treatment of Parkinson’s Disease DOI

Nikolina Kalčec,

Nikolina Peranić,

Ivan Mamić

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(19), P. 17581 - 17592

Published: Sept. 20, 2023

The development of efficient drug formulations for Parkinson's disease (PD) treatment is challenged by achieving pharmacokinetic profiles, reduced side effects, and better permeability through the blood–brain barrier (BBB). As nanoparticles may facilitate delivery drugs in brain due to their high-loading capacity ability cross biological barriers, we designed two different types selenium (SeNPs) that increase transport across BBB act as antioxidants at site action. SeNPs were functionalized with polyvinylpyrrolidone (PVP) polysorbate 20 (Tween) characterized terms size, size distribution, shape, surface charge, colloidal stability relevant media. Their drug-loading was tested using dopamine l-DOPA therapeutically active agents PD. Thermodynamic analysis revealed binding processes occurred spontaneously hydrogen bond/van der Waals interactions or electrostatic interactions. strongest interaction observed between PVP-SeNPs dopamine, which a constant several orders magnitude higher than Tween-SeNPs. However, addition human transferrin model plasma protein significantly this difference, indicates crucial role corona formation design nanodelivery systems. In vitro evaluation cell-free cellular transwell models showed internalization SeNP-loaded l-DOPA/dopamine endothelial cells, while facilitated l-DOPA, achieved PVP-SeNPs. Overall, high potential drug-delivery vehicles PD demonstrated.

Language: Английский

Citations

13
Targeted delivery of genistein for pancreatic cancer treatment using hyaluronic-coated cubosomes bioactivated with frankincense oil DOI

Nourhan G. Sallam,

Nabila Boraie, Eman Sheta

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 649, P. 123637 - 123637

Published: Nov. 25, 2023

Language: Английский

Citations

11
Modeling the Analysis Process of a Lipid-Based, Multi-Compartment Drug Delivery System DOI Open Access
Eliza Wolska, Małgorzata Sznitowska

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 460 - 460

Published: Feb. 8, 2025

Solid lipid microparticles (SLMs) are multi-compartment drug carriers that can be used in various forms via many routes of administration, primarily to obtain prolonged release, protect the substance or mask its taste. It is practically impossible theoretically predict effectiveness incorporation and distribution active pharmaceutical ingredients (APIs) SLMs, these fundamental features determine key properties dosage form. The possibility an effective assessment by selecting developing sensitive, universal methods, therefore, conditions further development practical use this carrier. Therefore, unlike already available review papers on aim mini-review focus solely issues API SLMs their release. For purpose, most important observations results our own research were collected summarized, then attempt was made confront them with literature data. Among methods describing critical attributes instrumental (DSC, AFM, Raman spectroscopy NMR), quantitative studies for assessing (including entrapment efficiency drug-loading parameters) as well different release techniques (without a membrane, dialysis bag horizontal chambers, taking into account physiological factors) characterized compared. facilitate understanding SLM assess ability achieve intended effect vivo, standardize such carriers, facilitating comparison between centers.

Language: Английский

Citations

0
Nano-Delivery Systems for Carotenoids: Enhancing Bioavailability and Therapeutic Potential in Neurodegenerative Diseases DOI
Hazem Golshany, Yang Ni, Qun Yu

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Feb. 25, 2025

Language: Английский

Citations

0
Whole secretome of mesenchymal stem cells is fully incorporated in lipid bicontinuous cubic phases DOI Creative Commons
Sandra Barata‐Antunes, Rui A. Sousa, António J. Salgado

et al.

Frontiers in Medical Engineering, Journal Year: 2025, Volume and Issue: 3

Published: March 21, 2025

Lipid bicontinuous cubic phases are precursors to cubosomes–a promising type of nanoparticle for the delivery multicomponent biomolecular mixtures applications in health such as regenerative medicine and wound healing. In this study, we showed that secretome mesenchymal stem cells (MSCs), a complex mixture growth factors, cytokines, extracellular vesicles, other cell-secreted molecules with therapeutic potential, can be fully incorporated into phytantriol monoolein. When was added dry lipid films, resulting partial phase diagrams these lipid-secretome systems, although more complex, resemble those their lipid-water analogs. Remarkably, visual inspections Small-Angle X-ray Scattering (SAXS) studies composition regions homogeneous solid-like mesophases without excess liquid phase-separation. This indicates diverse components, even varied sizes structures, integrated phases. SAXS patterns dominated by structural parameters close systems. suggests water-soluble proteins likely localize within water channels phase, which must exhibit flexibility accommodate sizes, through formation locally disordered channels. Extracellular vesicles associated membrane proteins, on hand, fusing integrating membranes. These findings underscore potential crystalline materials matrices entire secretome, paving way future secretome-based cell-free therapeutics tissue regeneration, neuroprotective anti-inflammatory treatments.

Language: Английский

Citations

0
Physicochemical and In Vitro Digestion Properties of Curcumin-Loaded Solid Lipid Nanoparticles with Different Solid Lipids and Emulsifiers DOI Creative Commons

Yasi Yu,

D. Chen, Yee‐Ying Lee

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(10), P. 2045 - 2045

Published: May 18, 2023

Curcumin-loaded solid lipid nanoparticles (Cur-SLN) were prepared using medium- and long chain diacylglycerol (MLCD) or glycerol tripalmitate (TP) as matrix three kinds of surfactants including Tween 20 (T20), quillaja saponin (SQ) rhamnolipid (Rha). The MLCD-based SLNs had a smaller size lower surface charge than TP-SLNs with Cur encapsulation efficiency 87.54–95.32% the Rha-based exhibited small but low stability to pH decreases ionic strength. Thermal analysis X-ray diffraction results confirmed that different cores showed varying structures, melting crystallization profiles. emulsifiers slightly impacted crystal polymorphism MLCD-SLNs largely influenced TP-SLNs. Meanwhile, transition was less significant for MLCD-SLNs, which accounted better stabilization particle higher during storage. In vitro studies emulsifier formulation greatly on bioavailability, whereby T20-SLNs much digestibility bioavailability SQ- Rha-SLNs possibly due difference in interfacial composition. Mathematical modeling membrane release further mainly released from intestinal phase faster rate compared other formulations. This work contributes understanding performance MLCD lipophilic compound-loaded has important implications rational design nanocarriers instructing their application functional food products.

Language: Английский

Citations

10
Optimization, Characterization and In-Vitro Cellular Uptake of Donepezil-Loaded NanoCrystVesicles DOI
Ashish Dhiman, Reetika Tandon, Kailash Ahirwar

et al.

Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 35(5), P. 1493 - 1505

Published: April 6, 2024

Language: Английский

Citations

3