Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 15, 2024

Abstract Immunotherapy has rapidly evolved in the past decades battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success certain hematologic malignancies, although they still face limitations, including high costs and toxic effects. Natural killer (NK cells), as a vital component of immune system, serve “first responders” context cancer development. In this literature review, we provide an updated understanding NK cell development, functions, their applications disease therapy. Furthermore, explore rationale for utilizing engineered therapies, such CAR-NK cells, discuss differences between CAR-T cells. We also insights into key elements strategies involved CAR design addition, highlight challenges currently encountered future directions research utilization, pre-clinical investigations ongoing clinical trials. Based on outstanding antitumor potential it is highly likely that will lead to groundbreaking advancements treatment future.

Language: Английский

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Diversity of group 1 innate lymphoid cells in human tissues

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(8), P. 1460 - 1473

Published: July 2, 2024

Language: Английский

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Global research trends on innate lymphoid cells in the brain, gut and lung field: a bibliometric and visualized analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Background ILCs play important roles in the brain, gut, and lungs. Researchers are attempting to establish a research framework on brain-gut-lung axis using ILCs. However, no one has yet conducted bibliometric analysis summarize findings. In this study, we utilized bibliometrics analyze emerging trends focal areas of intestine, lung. We aim provide references for future axis. Methods To conduct comprehensive fields lung, software such as HistCite, VOSviewer, CiteSpace. Our focused various aspects, including number publications, countries, authors, journals, co-cited documents, keywords. This approach allowed us gain valuable insights into landscape surrounding these specific fields. Results A total 8411 articles or reviews lung were included. The published shown consistent upward trend since 2003. 45279 authors from 99 countries have contributed articles. United States highest publications (n=3044) most cited (TGCS=210776). top three field David Artis, Marco Colonna Andrew NJ McKenzie. journal Immunity is authoritative choice researchers. main focuses include NK cell, ILC2, tumor immunity, multiple sclerosis, inflammatory bowel disease, airway inflammation, RORγT, immunotherapy. recent years, cancer microenvironment emerged hot keywords, particularly immunotherapy, PD-1 related directions, indicating potential shift focus. Conclusion European American been pivotal conducting ILCs, while China produced significant its impact still limited. Tumors likely emerge next points field. connection regulation between brain not fully understood, further investigation necessary explore role brain-lung

Language: Английский

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Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation

Immunological Reviews, Journal Year: 2024, Volume and Issue: 323(1), P. 107 - 117

Published: April 2, 2024

Summary Group 1 innate lymphoid cells (ILCs), comprising ILC1s and natural killer (NK cells), belong to a large family of developmentally related that lack rearranged antigen‐specific receptors. NK both require the transcription factor T‐bet for lineage commitment but additionally rely on Eomes Hobit, respectively, their development effector maturation programs. Both are essential rapid responses against infections mediate cancer immunity through production cytokines cytotoxicity mediators. enriched in tissues hence generally considered tissue resident whereas often circulatory. Despite being deemed different cell types, share many common features phenotypically functionally. Recent studies employing single RNA sequencing (scRNA‐seq) technology have exposed previously unappreciated heterogeneity group ILCs further broaden our understanding these cells. Findings from imply organs signature exhibit some unique characteristics, possibly stemming imprinting. Also, data recent fate mapping RORγt, polychromic reporter mice greatly advanced developmental programs In this review, we aim outline fundamental traits mouse explore discoveries programs, phenotypic heterogeneity, plasticity, transcriptional regulation.

Language: Английский

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Ovarian cancer treatment and natural killer cell-based immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 21, 2023

Background Ovarian cancer (OC) is one of the malignant tumors that poses a serious threat to women’s health. Natural killer (NK) cells are an integral part immune system and have ability kill tumor directly or participate indirectly in anti-tumor response. In recent years, NK cell-based immunotherapy for OC has shown remarkable potential. However, its mechanisms effects remain unclear when compared standard treatment. Methods To explore value treatment OC, we conducted literature review. comparison treatment, our focus was primarily on current mechanisms, clinical effect against factors affecting structure function cells, strategies enhance effectiveness cells. Results We found exert their therapeutic through such as antibody-dependent cell cytotoxicity, perforin release, granule enzyme secretion. They also secrete IFN-γ TNF-α engage Fas/FasL TRAIL/TRAILR pathways, mediating death trials, majority patients experienced disease stability with mild side after receiving immunotherapy, but there still lack high-quality research evidence regarding effectiveness. prior experience treatments it may be considered maximize modulation microenvironment combination other therapies. Conclusions this review, summarized applications OC. Furthermore, influence role discussed.

Language: Английский

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Inflammation and cancer: molecular mechanisms and clinical consequences

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 17, 2025

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy anticancer treatments in cancer. It affects all stages from the initiation carcinogenesis to metastasis. Chronic inflammation induces immunosup-pression, providing an environment conducive carcinogenesis, whereas acute antitumor immune response, leading suppression. Solid tumors have inflammatory microenvironment (TME) containing cancer cells, stromal soluble molecules, which plays key role progression therapy response. Both cells TME are highly plastic constantly change their phenotypic functional properties. Cancer-associated inflammation, majority consists innate important cell plasticity, development drug resistance. Today, combined used advanced technologies, such as single-cell RNA sequencing spatial molecular imaging analysis, pathways linking chronic largely elucidated. In this review article, we highlighted cellular mechanisms involved cancer-associated its effects on treatment We also comprehensively setting GI cancers.

Language: Английский

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Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 9, 2023

Here, we have explored the involvement of innate lymphoid cells-type 1 (ILC1) in pathogenesis alopecia areata (AA), because found them to be significantly increased around lesional and non-lesional HFs AA patients. To further explore these unexpected findings, first co-cultured autologous circulating ILC1-like cells (ILC1lc) with healthy, but stressed, organ-cultured human scalp hair follicles (HFs). ILClc induced all hallmarks ex vivo: they promoted premature, apoptosis-driven HF regression (catagen), cytotoxicity/dystrophy, most important for pathogenesis, collapse physiological immune privilege. NKG2D-blocking or IFNγ-neutralizing antibodies antagonized this. In vivo, intradermal injection activated, NKG2D+/IFNγ-secreting ILC1lc into healthy skin xenotransplanted onto SCID/beige mice sufficed rapidly induce characteristic lesions. This provides evidence that ILC1lc, which are positive ILC1 phenotype negative classical NK markers, suffice previously vivo questions conventional wisdom is always an autoantigen-dependent, CD8 +T cell-driven autoimmune disease.

Language: Английский

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Cytokine-mediated regulation of immune cell metabolic pathways in the tumor microenvironment

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

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Type I interferon regulation of group I ILC subsets during both homeostasis and cytomegalovirus infection

The Journal of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Type 1 innate lymphoid cells (ILC1s) and conventional natural killer belong to the group ILCs (gILC1), characterized largely by T-bet expression interferon γ secretion. While much has been done define factors that regulate development, differentiation, effector functions of both cell types, little is known about what controls gILC1 homeostasis. Here, mixed bone marrow chimeras were used role type I receptor (IFNAR) signaling in regulating spleen liver at homeostasis during murine cytomegalovirus infection. We show basal IFNAR induces tissue-specific phenotypic changes gILC1, inhibiting bona-fide ILC1 markers (CD49a, CD200R, CXCR6) perforin granzymes B C. Finally, while enhances cytokine responsiveness vitro subsets, it a dichotomous effect on production infection, stimulating ILC1.

Language: Английский

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Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 17, 2024

Abstract Background GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on unique interaction between microenvironment (TME). However, currently available methods for prognostic prediction are not satisfactory. Therefore, this study aims construct novel model that integrates relevant gene sets predict clinical efficacy of immunotherapy prognosis patients based machine learning. Methods Seven datasets were collected from Gene Expression Omnibus (GEO) database, The Cancer Genome Atlas (TCGA) database literature sources. Based cohort, we first obtained list related genes through differential expression analysis. Then, Cox regression analysis was applied divide these significancy into protective risky types. Single Sample Set Enrichment Analysis (ssGSEA) algorithm used score two categories separately, scores differences as basis constructing model. Subsequently, Weighted Correlation Network (WGCNA) Cytoscape further screen constructed model, finally COX7A1 selected exploration relationship GC. correlation immune cell infiltration, drug sensitivity scoring, immunohistochemical staining performed initially understand potential role in development progression Finally, verified those receiving immunotherapy. Results First, 47 408 obtained, ssGSEA construction, showing good discrimination ability. In addition, high showed higher TMB MSI levels, lower heterogeneity scores. it found expressions tissues significantly than their corresponding paracancerous tissues. Meanwhile, probability cancer invasion, worse overall survival (OS) disease-free (DFS). Conclusions can serve biomarker provide important guidance individualized treatment. accurately distinguish patients.

Language: Английский

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