Besonderheiten rheumatischer Erkrankungen im Alter DOI
Olaf Schultz

Aktuelle Rheumatologie, Journal Year: 2024, Volume and Issue: 49(05), P. 291 - 300

Published: Aug. 9, 2024

Zusammenfassung Aufgrund der erhöhten Lebenserwartung und anhand epidemiologischer Daten zeigt sich eine Zunahme rheumatische Erkrankungen älterer Menschen. Diese Population ist durch ein erhöhtes Risiko für kardiovaskuläre, infektiöse, neoplastische iatrogene Komplikationen betroffen. Multimorbidität in Verbindung mit Polypharmazie progredienten funktionellen Defiziten haben erheblichen Einfluss auf den klinischen Verlauf die Therapieentscheidungen bei Altersvarianten rheumatischer Erkrankungen. Der Altersprozess des Immunsystems geprägt von Immunseneszenz „Inflammaging“ Folge eines Risikos Infektionen Tumorerkrankungen, verringerten regenerativen Potentials einer verstärkten unspezifischen Entzündungskonstellation. Neben wenigen alterstypischen rheumatischen wie Polymyalgia rheumatica gibt es Altersformen Erkrankungen, hinsichtlich Symptomatik, Pathophysiologie, Labordiagnostik Prognose Besonderheiten aufweisen. Atypische Krankheitsverläufe Mischbilder degenerativen oder anderen entzündlichen sind nicht ungewöhnlich. In Übersichtsarbeit werden speziellen verschiedener vorgestellt. Ältere Patienten derzeitige Studienlage adäquat erfasst. Ein wesentlicher Schwerpunkt künftiger klinisch-rheumatologischer Forschung sollte stärkere Einbeziehung dieser sein, um angepasste integrative Therapiekonzepte Morbidität Mortalität zu reduzieren.

Vitamin K: Infection, Inflammation, and Auto-Immunity DOI Creative Commons
Yuanyuan Xie, Shifang Li,

Dinan Wu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1147 - 1160

Published: Feb. 1, 2024

Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature the form VK1 VK2.As its initial recognition originated from ability to promote blood coagulation, it is known as coagulation vitamin.However, based on extensive research, VK has shown potential for prevention treatment various diseases.Studies demonstrating beneficial effects immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, bone protection have drawn growing interest recent years.This review article focuses mechanism action preventive therapeutic infections (eg, asthma, COVID-19), inflammation type 2 diabetes mellitus, Alzheimer's disease, Parkinson's cancer, aging, atherosclerosis) autoimmune disorders inflammatory bowel 1 multiple sclerosis, rheumatoid arthritis).In addition, VK-dependent proteins (VKDPs) are another crucial by which exerts anti-inflammatory immunomodulatory effects.This explores role preventing combating neurological abnormalities, treating diseases such cancer diabetes.Although current research appoints tool practical clinical applications infections, inflammation, diseases, future necessary elucidate more detail overcome limitations.

Language: Английский

Citations

15
Inflammation and aging-related disease: A transdisciplinary inflammaging framework DOI
Brian J. Andonian, Joseph A. Hippensteel, Katrina Abuabara

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

8
Metabolic Checkpoints in Rheumatoid Arthritis DOI

Cornelia M. Weyand,

Jörg J. Goronzy

Seminars in Arthritis and Rheumatism, Journal Year: 2024, Volume and Issue: unknown, P. 152586 - 152586

Published: Nov. 1, 2024

Language: Английский

Citations

6
MicroRNA‐7 deficiency ameliorates d‐galactose‐induced aging in mice by regulating senescence of Kupffer cells DOI Creative Commons
Ya Wang,

Hui Qiu,

Shipeng Chen

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(6)

Published: March 17, 2024

Abstract Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA‐7 (miR‐7) as a novel regulator cell and related diseases. However, potential role miR‐7 in aging remains unexplored. Here, we investigated contribution d ‐gal‐induced mice, focusing on its regulation senescent Kupffer cells. Our findings revealed that deficiency significantly ameliorated process, characterized by enhanced CD4 + T‐cell activation. adoptive transfer miR‐7‐deficient T cells failed improve age‐related phenotype. Further analysis showed reduced IL‐1β production liver tissue, inhibiting vivo slowed down process mice. Notably, mainly produced tissue expression was up‐regulated these Mechanistically, KLF4, target miR‐7, down‐regulated mouse model. Furthermore, also modulated NF‐κB activation through KLF4. In conclusion, our unveil highlighting KLF4/NF‐κB/IL‐1β pathways This research may enhance understanding miRNA‐based offer new avenues for intervention strategies process.

Language: Английский

Citations

4
Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis DOI
Abhinav Lamba, Veena Taneja

Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 90 - 106

Published: June 12, 2024

Rheumatoid arthritis (RA) is considered a multifactorial condition where interaction between the genetic and environmental factors lead to immune dysregulation causing autoreactivity. While among various factors, HLA-DR4 DQ8, have been reported be strongest risk role of has unclear. Though events initiating autoreactivity remain unknown, mucosal origin RA gained attention based on recent observations with gut dysbiosis in patients. However, causality difficult prove humans. Mouse models, especially mice expressing RA-susceptible -resistant HLA class II genes helped unravel complex interactions microbiome. This review describes sex-biased preclinical discusses potential use endogenous commensals as indicators treatment efficacy well therapeutic tool suppress pro-inflammatory response rheumatoid arthritis.

Language: Английский

Citations

4
A researcher's guide to studying sex differences in immune aging DOI
Clayton Baker, Minhoo Kim, Bérénice A. Benayoun

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Sexual dimorphism in immunity and longevity among the oldest old DOI Creative Commons

Nelli A. Arakelyan,

D. A. Kupriyanova,

Jeļena Vasiļevska

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Human longevity is a sex-biased process in which sex chromosomes and sex-specific immunity may play crucial role the health lifespan disparities between men women. Generally, women have higher life expectancy than men, exhibiting lower infection rates for broad range of pathogens, results prevalence female centenarians compared to males. Investigation immunological changes that occur during healthy aging, while taking into account differences sexes, can significantly enhance our understanding mechanisms underlie longevity. In this review, we aim summarize current knowledge on sexual dimorphism human immune system gut microbiome with particular focus centenarians, based exclusively data.

Language: Английский

Citations

0
Roadmap for alleviating the manifestations of ageing in the cardiovascular system DOI
Luca Liberale, Simon Tual‐Chalot, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases DOI Creative Commons
Hanzhang Wu,

Jiahe Wei,

Yuefeng Yu

et al.

Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related expansion blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate association between CHIP and established autoimmune diseases. We analyzed baseline data from 456,692 UK Biobank participants available whole-exome sequences. The primary outcome was 19 disorders. Associations among any (variant allele fraction ≥2%), large clones ≥10%), gene-specific subtypes incidence diseases were assessed using Cox regression. Mediation analysis performed explore role inflammation in link identified 17,433 11,970 at baseline. Participants 44% 43% higher risk for Crohn's disease, 25% 33% psoriasis, 13% 14% rheumatoid arthritis, 35% 55% vasculitis, respectively. status increased levels inflammatory markers, including white cell, platelets, neutrophils, neutrophil-to-lymphocyte ratio, overall mediation ratios 16.3% 7.1% 23.2% 7.2% vasculitis. an incident multiple diseases, potentially mediated elevated levels. Future research needed clarify mechanisms underlying these associations interventions reduce risk.

Language: Английский

Citations

0
Bidirectional causal association between type 1 diabetes and autoimmune diseases: a Mendelian randomization study DOI Creative Commons
Liang Han, Y.H. Su, Hua Huang

et al.

Archives of Medical Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Introduction It has been reported that individuals with type 1 diabetes (T1D) are at a higher risk of concomitant occurrence other autoimmune diseases (AIDs). Currently, there is lack research investigating the causal relationship between T1D and AIDs. A comprehensive Mendelian randomization (MR) study was conducted using debiased inverse-variance weighted (dIVW) (IVW) estimators to examine bidirectional 12 Material methods Genome-wide association (GWAS) summary statistics datasets related or AIDs were obtained from FinnGen published cohort studies. Pruned SNPs in linkage disequilibrium (LD)-clumped single-nucleotide polymorphisms (SNPs) used as instrumental variables. For dIVW analysis, no genome-wide significance threshold applied for SNP selection. Results each 1-unit increase log-transformed odds ratio (OR) patients primary biliary cholangitis (PBC) rheumatoid arthritis (RA), ORs 1.123 (95% CI: 1.094–1.151) 1.133 1.100–1.167), respectively. Conversely, OR T1D, RA 1.383 1.213–-1.578). No associations found Conclusions Patients PBC have developing those also an increased RA. These findings highlight importance regular screening RA, PBC.

Language: Английский

Citations

0