Nature Immunology, Journal Year: 2023, Volume and Issue: 24(11), P. 1799 - 1800
Published: Oct. 16, 2023
Language: Английский
npj Aging, Journal Year: 2024, Volume and Issue: 10(1)
Published: Feb. 6, 2024
Abstract The involvement of cellular senescence in the initiation and propagation diseases is clearly characterized, making elimination senescent cells essential to treat age-related diseases. development senolytic drugs demonstrated that targeting these limits deterioration patients’ condition, by inducing apoptosis. Nevertheless, first generations senolytics which has been developed displayed their activities through specific mechanisms several limitations during clinical development. However, rational eliminate remains evident, with necessity develop therapies a context tissues. evolutions field drug discovery open way new generation therapies, such as immunological approaches (CAR-T cells, Antibody-Drug Conjugated or vaccines), require preliminary steps research identify markers specifically expressed on demonstrating promising effects. Currently, preclinical strategies appears more challenging avoid strong side effects, but expected results are commensurate hopes for treatments. In this review, we highlight fact classical approach based repurposing display limited efficacy probably reached its term recent complex extension interest domain different fields allow extend possibility discover powerful therapies. future treatment linked cell therapy immunotherapy offer best patients.
Language: Английский
Citations
29
Nature Reviews Drug Discovery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
0
Clinical & Translational Immunology, Journal Year: 2025, Volume and Issue: 14(3)
Published: Jan. 1, 2025
Abstract Objectives Myocardial ischaemia and remodelling are major contributors to the progression mortality of coronary artery disease (CAD). Previous studies have shown immune cell alterations in CAD patients, but their characteristics associations with myocardial remain unclear. Methods We compared changes among patients without CAD, those heart failure (HF). Results found a progressive reduction circulating mucosal‐associated invariant T (MAIT) cells across three patient groups. MAIT exhibited increased expression activation markers (CD69 PD‐1) cytotoxic molecules (such as granzyme B). The features were correlated positively worsening clinical indicators remodelling, including Gensini score, cTnI, NT‐proBNP, LVEF E/e′. Additionally, reduction, cytotoxicity associated fibrosis (sST2, Gal‐3, PICP PIIINP), central pathological mechanism remodelling. Finally, we preliminarily explored potential triggers for abnormalities that impaired intestinal barrier function bacterial antigens may contribute these changes. Conclusions During progression, observed decrease cells. Enhanced failure, potentially triggered by gut microbial leakage. Our findings suggest novel strategy monitoring intervention progression.
Language: Английский
Citations
0
Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 218, P. 111918 - 111918
Published: Feb. 23, 2024
Language: Английский
Citations
3
Computational Biology and Chemistry, Journal Year: 2024, Volume and Issue: 112, P. 108148 - 108148
Published: July 10, 2024
Accumulation of senescent cells is a recognized feature in hepatocellular carcinoma (HCC), but their specific types and prognostic implications remain under investigation. This study aimed to delineate cell patterns HCC using publicly available bulk single-cell mRNA sequencing data. Through gene expression set enrichment analysis, we identified distinct within samples. Notably, unconventional T cells, specifically natural killer γδT were found be the predominant types. These exhibited enriched pathways related DNA damage, senescence negative regulation lymphocyte activation. Furthermore, observed upregulation mTOR signaling pathway, which correlated positively with senescence-associated genes. suggests potential regulatory role for HCC. Strikingly, patients elevated markers, including p16INK4A, p21, GLB1, demonstrated significantly reduced overall survival rates. Our findings indicate that immunosenescence may play progression. The therapeutic targeting pathway or eliminating warrant further exploration improve patient outcomes.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15468 - 15468
Published: Oct. 23, 2023
Aging is a natural, gradual, and inevitable process associated with series of changes at the molecular, cellular, tissue levels that can lead to an increased risk many diseases, including cancer. The most significant genomic level (DNA damage, telomere shortening, epigenetic changes) non-genomic are referred as hallmarks aging. aging cancer intertwined. Many studies have focused on hallmarks, but also important may additionally cause damage increase expression hallmarks. Understanding cancer, how they intertwined, development approaches could influence these thus function not only slow prevent In this review, we focus changes. We discuss cell senescence, disruption proteostasis, deregualation nutrient sensing, dysregulation immune system function, intercellular communication, mitochondrial dysfunction, stem exhaustion dysbiosis.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 14, 2024
Liver cancer is the third leading of tumor death, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Immune checkpoint inhibitors (ICIs) are yielding much for sufferers to hope patients, but only some patients with advanced liver respond. Recent research showed that microenvironment (TME) critical effectiveness ICIs in tumor. Meanwhile, metabolic reprogramming leads immunosuppression TME. These suggest regulating abnormal metabolism cells firing up TME turn “cold tumor” into “hot potential strategies improve therapeutic effect Previous studies have found YAP1 a target efficacy anti-PD-1 HCC. Here, we review promotes TME, mainly due overstimulation cytokines by YAP1. Subsequently, studied effects on cells, glycolysis, gluconeogenesis, lipid metabolism, arachidonic acid amino metabolism. Lastly, summarized existing drugs targeting treatment tumor, medicines from natural sources, which This contributed application targeted combined therapy patients.
Language: Английский
Citations
2
Published: Aug. 12, 2024
Cellular senescence is a permanent condition of cell cycle arrest caused by progressive shorten-ing telomeres defined as replicative senescence. Stem cells may also undergo an accelerated se-nescence response, distinct from telomere shortening, known premature re-sponse to different stress agents. Various treatment protocols have been developed based on epi-genetic changes in throughout senescence, using drugs and antioxidants, senolytic vaccines, or reprogramming somatic senescent Yamanaka factors. Even with all the recent advancements, it still unknown how epigenetic modifications interact ge-netic profile other factors such microbiota physiological conditions, psychological states diet influence interaction between genetic pathways. The aim this review highlight new that are involved stem Here, we senescence-related alterations DNA methylation, chro-matin remodeling, histone modification, RNA non-coding regulation outlining possible targets for therapy aging-related diseases. advantages disad-vantages animal models used study cellular briefly presented.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9708 - 9708
Published: Sept. 7, 2024
Cellular senescence is a permanent condition of cell cycle arrest caused by progressive shortening telomeres defined as replicative senescence. Stem cells may also undergo an accelerated response known premature senescence, distinct from telomere shortening, to different stress agents. Various treatment protocols have been developed based on epigenetic changes in throughout using drugs and antioxidants, senolytic vaccines, or the reprogramming somatic senescent Yamanaka factors. Even with all recent advancements, it still unknown how modifications interact genetic profiles other factors such microbiota physiological conditions, psychological states, diet influence interaction between pathways. The aim this review highlight new that are involved stem Here, we senescence-related alterations DNA methylation, chromatin remodeling, histone modification, RNA non-coding regulation outlining possible targets for therapy aging-related diseases. advantages disadvantages animal models used study cellular briefly presented.
Language: Английский
Citations
2
European Respiratory Review, Journal Year: 2024, Volume and Issue: 33(172), P. 230266 - 230266
Published: April 30, 2024
Respiratory viral infections frequently lead to severe respiratory disease, particularly in vulnerable populations such as young children, individuals with chronic lung conditions and older adults, resulting hospitalisation and, some cases, fatalities. The innate immune system plays a crucial role monitoring for, initiating responses to, viruses, maintaining state of preparedness through the constant expression antimicrobial defence molecules. Throughout course infection, immunity remains actively involved, contributing clearance damage control, pivotal contributions from airway epithelial cells resident newly recruited cells. In instances where persist or are not effectively eliminated, components prominently contribute pathophysiological consequences. Even though both children adults susceptible disease caused by various underlying mechanisms may differ significantly. Children face challenge developing maturing their immunity, while contend issues senescence inflammaging. This review aims compare across age groups, identifying common central hubs that could serve promising targets for innovative therapeutic preventive strategies, despite apparent differences mechanisms.
Language: Английский
Citations
1