Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12550 - 12550

Published: Nov. 22, 2024

Malignant tumors can evade immune surveillance and elimination through multiple mechanisms, with the induction of cell dysfunction serving as a crucial strategy. Mounting evidence indicates that T senescence constitutes primary mechanism underlying in acute myeloid leukemia (AML) represents one potential causes immunotherapy failure. AML usually progresses rapidly is highly susceptible to drug resistance, thereby resulting recurrence patient mortality. Hence, disrupting interface within bone marrow microenvironment has emerged critical objective for synergistically enhancing tumor immunotherapy. In this review, we summarize general characteristics, distinctive phenotypes, regulatory signaling networks senescent cells highlight their clinical significance AML. Additionally, discuss therapeutic strategies alleviating reversing senescence.

Language: Английский

The immunology and cell biology of T cell aging

Seminars in Immunology, Journal Year: 2023, Volume and Issue: 70, P. 101843 - 101843

Published: Sept. 28, 2023

Language: Английский