Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity DOI Creative Commons
Yujuan Li,

Mengxin Que,

Xuan Wang

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2476 - 2476

Published: Sept. 7, 2023

Astrocytes, the most abundant cells in brain, are integral to sleep regulation. In context of a healthy neural environment, these glial exert profound influence on sleep-wake cycle, modulating both rapid eye movement (REM) and non-REM phases. However, emerging literature underscores perturbations astrocytic function as potential etiological factors disorders, either protopathy or comorbidity. As known, disorders significantly increase risk neurodegenerative, cardiovascular, metabolic, psychiatric diseases. Meanwhile, commonly screened comorbidities various neurodegenerative diseases, epilepsy, others. Building existing research that examines role astrocytes this review aims elucidate mechanisms by which regulation contribute varied settings brain The emphasizes significance astrocyte-mediated their associated comorbidities, highlighting need for further research.

Language: Английский

Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis DOI Creative Commons

Jeremy R. Chang,

Rachel Lai‐Chu Kwan, Rui Sun

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Sleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite strong association between the 2 conditions, potential mechanisms underlying role of sleep CLBP remain unclear. This case–control study aimed to examine perception among females or without nonspecific and comorbid insomnia. One hundred were recruited (mean age: 34.3 ± 11.4 years), 25 concomitant insomnia (CLBP+I), (CLBP+), (Insomnia+), healthy controls. All participants completed self-report questionnaires quantitative sensory testing (QST). Our found that CLBP+I exhibited lower mechanical pressure thresholds (PPT) both painful nonpainful areas impaired conditioned modulation (CPM) as compared Similar findings PPT at CPM when CLBP+. However, no significant differences noted thermal temporal summation across 4 groups. Furthermore, Insomnia+ displayed higher levels functional disability, maladaptive beliefs, negative mood than CLBP+ There increases sensitivity stimuli, decreases descending inhibitory effects, psychological status These underscore importance incorporating assessments routine practice treating cases. Future studies are warranted validate our males, establish diagnostic prognostic value QST, probe neurophysiological conditions.

Language: Английский

Citations

1
Sleep disorders in chronic pain and its neurochemical mechanisms: a narrative review DOI Creative Commons

Lan Duo,

Xintong Yu,

Ruihan Hu

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: June 1, 2023

Chronic pain (CP) is a prevalent problem, and more than half of patients with CP have sleep disorders. comorbidity disorders imposes immense suffering seriously affects the patient’s quality life, which challenging issue encountered by clinicians. Although reciprocal interactions between been studied to some degree, there still lack awareness comprehensive description In this narrative review article, we summarize current knowledge about present estimates prevalence comorbid in patients, detection methods, characterization CP, effect on therapies. We also neurochemical mechanisms conclusion, insufficient attention has paid role should be screened for clinic. Special given possible risk drug–drug interaction when using two types drugs targeting simultaneously. The insight into neurobiological underlying rather limited.

Language: Английский

Citations

20
The bidirectional relationship between sleep problems and chronic musculoskeletal pain: a systematic review with meta-analysis DOI
Nils Runge, Ishtiaq Ahmed, Tobias Saueressig

et al.

Pain, Journal Year: 2024, Volume and Issue: 165(11), P. 2455 - 2467

Published: May 28, 2024

Abstract Chronic musculoskeletal pain and sleep problems/disorders exhibit a recognized bidirectional relationship; yet, systematic investigations of this claim, particularly in prospective context, are lacking. This review with meta-analysis aimed to synthesize the literature on associations between chronic pain. A comprehensive search across 6 databases identified longitudinal cohort studies adults examining relationship Random-effects meta-analyses, using Hartung–Knapp adjustment for 95% confidence intervals (CIs), were conducted, all results presented as odds ratios (ORs). Certainty evidence was evaluated Grading Recommendations, Assessment, Development, Evaluations approach. Including 16 articles from 11 study populations (116,746 participants), meta-analyses indicated that problems at baseline may heighten risk both short term (OR 1.64, CI 1.01-2.65) long 1.39, 1.21-1.59). The different problem categories very uncertain. increase short-term 1.56, 1.02-2.38), but long-term impact only local or widespread uncertain, whereas elevate 2.0, 1.81-2.21). In conclusion, suggests associated an increased pain, nature requires further investigation.

Language: Английский

Citations

7
Prevalence of musculoskeletal disorders and associated risk factors in canadian university students DOI Creative Commons

Dorsa Nouri Parto,

Arnold Yu Lok Wong, Luciana Macedo

et al.

BMC Musculoskeletal Disorders, Journal Year: 2023, Volume and Issue: 24(1)

Published: June 19, 2023

Musculoskeletal disorders (MSKDs) present a significant burden to health care systems worldwide. Evidence suggests that university students may have unique risk factors for developing MSKDs; however, research on the corresponding prevalence and of MSKDs in Canadian is limited.Using multi-year cross-sectional survey, we aimed understand at McMaster University. A survey MSKD as well potential was conducted online years 2018-2022. Our outcomes were over last 7 days 12 months, presence lower body, upper spine MSKDs. We investigated using negative binomial regression analysis, including sex-stratified analysis.There total 289 respondents 2018 with decrease number participants subsequent (n2019 = 173, n2020 131, n2021 76). Participants reported median 2-3 pain sites year 1-2 week all four years. The most prevalent sources self-reported back neck. Depending outcome studied, 59-67% neck/lower year, 43-49% it week. Although different depending sex, overall, poorer mental health, being studies, regular sports participation (males only), older age, less hours sleep significantly associated higher MSKDs.This study identified are source students. While some factors, such known play role MSKDs, activity academic pressure also there be differences between sexes.

Language: Английский

Citations

16
Precision management of post‐COVID pain: An evidence and clinical‐based approach DOI Creative Commons
César Fernández‐de‐las‐Peñas, Jo Nijs, Rocco Giordano

et al.

European Journal of Pain, Journal Year: 2023, Volume and Issue: 27(9), P. 1107 - 1125

Published: Feb. 28, 2023

Abstract Background Pain after a SARS‐CoV‐2 acute infection (post‐COVID pain) is becoming new healthcare emergency but remains underestimated and most likely undertreated due to lack of recognition the phenomenon knowledge underlying pain mechanisms. Evidence supporting any particular treatment approach for management post‐COVID lacking. Large variability in patient response standard treatments clinically observed, which has led calls personalized, tailored treating patients with chronic (i.e. ‘precision medicine’). Applying global concerted action towards precision medicine could help guide clinical decision‐making aid more effective treatments. Methods The current position paper discusses factors be considered by clinicians managing ranging from identification phenotype genetic consideration. Results ability into nociceptive, neuropathic, nociplastic or mixed type suggested as first step better planification programme. Further, consideration other factors, such gender, comorbidities, received at phase onset‐associated COVID‐19 symptoms, during hospitalization presence emotional disturbances should implemented Conclusions Accordingly, considering these include multimodal pharmacological non‐pharmacological modalities targeting emotional/cognitive aspects psychological and/or coping strategies), central sensitization‐associated mechanisms neuroscience education), exercise programmes well lifestyle interventions (e.g. nutritional support sleep management). Significance This presents an evidence‐based reasoning pain.

Language: Английский

Citations

15
A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress DOI Creative Commons
Shuhan Chen,

Yanle Xie,

Zenghui Liang

et al.

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1785 - 1792

Published: May 1, 2024

Abstract: Sleep is crucial for human health, insufficient sleep or poor quality may negatively affect function and lead to a state of deprivation. deprivation can result in various health problems, including chronic pain. The intricate relationship between pain complex intertwined, with daytime affecting increasing intensity. article first describes the influence on onset development pain, then explores impact intensity nighttime subsequent thresholds. However, primary emphasis placed pivotal role oxidative stress this bidirectional relationship. Although exact mechanisms underlying are unclear, review focuses stress. Numerous studies have demonstrated that it varying degrees increased sensitivity, while leads further exacerbates Further research mechanism deprivation-induced sensitization seems reasonable. This comprehensively reviews current interrelationship deprivation, Keywords: stress, antioxidants

Language: Английский

Citations

6
The relationship between preoperative sleep disturbance and acute postoperative pain control: a systematic review and meta-analysis DOI Creative Commons

Andrea Niklasson,

Patrick H. Finan,

Michael T. Smith

et al.

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 79, P. 102014 - 102014

Published: Oct. 5, 2024

Language: Английский

Citations

6
The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain DOI Creative Commons

Manmin Zhu,

Hao Huang

Nature and Science of Sleep, Journal Year: 2023, Volume and Issue: Volume 15, P. 579 - 591

Published: July 1, 2023

Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals humans, for example by increasing sensitivity to pain. However, the mechanism which affects neuropathic remains unclear. In this review, we discuss available evidence from epidemiologic, clinical, human, as well laboratory studies. previous studies, have found that various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamic-pituitary-adrenal axis, adenosine. At same time, these systems play a crucial role regulation. complex interactions between neurobiological there may be potential regulatory pathways through amplifies Because of impact problems on patients' quality life, studying link is important prevention public health.

Language: Английский

Citations

13
The impact of sleep disturbance on pain perception: A systematic review examining the moderating effect of sex and age DOI Creative Commons
Shima Rouhi, J Topcu, Natalia Egorova

et al.

Sleep Medicine Reviews, Journal Year: 2023, Volume and Issue: 71, P. 101835 - 101835

Published: Aug. 8, 2023

Females have increased pain sensitivity and are more vulnerable to chronic conditions. Sleep disturbances comorbid with exacerbate symptoms. Different types of sleep disturbance affect perception distinctly, but it is not clear if these effects equal in men women. This systematic review investigated potential differences how affects males females. We searched EBSCO, MEDLINE, Psych INFO, Science Direct, Web from January 2001 November 2022 found 38 studies 978 participants. Separate random-effects models were used estimate the pooled effect sizes based on standardized mean (SMDs) experimental paradigms various outcomes. Sex moderated facilitation (SMD = 0.13; 95%CI: 0.004 0.022; p=.009) inhibition 0.033; 0.011 0.054; p=.005), decreased females, opposite males. Further, age total deprivation -0.194; 95%CI -0.328 -0.060; p=.008) fragmented -0.110; 0.148 -0.072; p<.001) threshold. While moderating sex sleep-pain relationship was small, factors need be considered future research.

Language: Английский

Citations

13
Relationship between insomnia and pain in patients with chronic orofacial pain DOI
Anna Alessandri‐Bonetti, Linda Sangalli, Ian A. Boggero

et al.

Pain Medicine, Journal Year: 2024, Volume and Issue: 25(5), P. 319 - 326

Published: Jan. 22, 2024

Abstract Objective Few studies have investigated specific associations between insomnia and orofacial pain (OFP). The aim of this cross-sectional study was to examine relationships with pain, mental health, physical health variables among treatment-seeking patients chronic OFP. Methods OFP diagnosis, demographics, symptoms, intensity, interference, duration, measures, number medical comorbidities were extracted from the records 450 receiving an initial appointment at a university-affiliated tertiary clinic. T-tests compared differences without symptomatology, different subtypes (delayed onset/early wakening). Results Compared insomnia, those elevated symptomatology (45.1%) reported higher intensity (60.70 ± 20.61 vs 44.15 21.69; P &lt; .001) interference (43.81 29.84 18.40 23.43; 0.001), depression/anxiety (5.53 3.32 2.72 2.66; dissatisfaction life (21.63 6.95 26.50 6.21; .001), (6.72 5.37 4.37 4.60; .001). Patients Sleep Onset Latency (SOL-insomnia) (N = 76) (t 3.57; 4.46; SOL-insomnia. Those Early Morning Awakening (EMA-insomnia) 71) did not significantly differ EMA-insomnia on any variables. Differences remained significant after adjusting for age, sex, primary intensity. Conclusions Insomnia is associated outcomes should be appropriately managed when treating

Language: Английский

Citations

4