Continuous Sheathless Particle Separation in Viscoelastic Fluids with Different Rheological Properties DOI Creative Commons

Chong‐Shan Gan,

Zhuangzhuang Tian,

Lv Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Abstract The separation of particles such as cells and bacteria in viscoelastic fluids has significant applications biomedical fields. At present, one the main challenges that limit application microfluidic technology is to separate with different rheological properties. For instance, most exisiting devices can only work fluid a specific property, resulting requirement time-consuming design, manufacturing, testing, optimization In this work, new particle strategy first focusing, then initial separation, precise (FISPS) was proposed, novel hybrid three-stage device where micropore structure utilized connect two gradually contracted microchannels designed achieve efficient continuous over wide range properties (0.07 < El 340.41). showed mechanism (ISPS) at 0.14 while it > 8.43. addition, transformation from ISPS FISPS found under flow conditions transitional (0.21 1.10). effect rate property on microparticle were systematically studied by experiment. With simple structure, easy operation, high efficiency, present would have great potentials clinical applications, for patients.

Language: Английский

Numerical simulation of radiation force synthesis by pulsed acoustic waves DOI
Shuhan Chen, Jia Zhou, Antoine Riaud

et al.

Physical Review Applied, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 2, 2025

Selective acoustic tweezers can focus the radiation force on a single particle to manipulate it without affecting its neighbors. Traditionally, this has required highly complex and specialized hardware, incompatible with high-throughput manipulation. In two-dimensional numerical study, we demonstrate that two pairs of orthogonal transducers, known for manipulating arrays particles, also achieve selective Specifically, show selectivity is possible by using sequences pulses iteratively construct combined potential focused solely target particle. locked icon Physics Subject Headings (PhySH)Acoustic wave phenomenaAcoustofluidicsNonlinear acousticsAcoustic tweezersMicrofluidic devicesFinite-element methodSurface waveUltrasound techniques

Language: Английский

Citations

2
Piezoelectric MEMS—evolution from sensing technology to diversified applications in the 5G/Internet of Things (IoT) era DOI
Xianhao Le, Qiongfeng Shi, Philippe Vachon

et al.

Journal of Micromechanics and Microengineering, Journal Year: 2021, Volume and Issue: 32(1), P. 014005 - 014005

Published: Nov. 17, 2021

Abstract The rapid development of the fifth-generation mobile networks (5G) and Internet Things (IoT) is inseparable from a large number miniature, low-cost, low-power sensors actuators. Piezoelectric microelectromechanical system (MEMS) devices, fabricated by micromachining technologies, provide versatile platform for various high-performance sensors, actuators, energy harvesters, filters oscillators (main building blocks in radio frequency front-ends wireless communication). In this paper, we comprehensive review working mechanism, structural design, diversified applications piezoelectric MEMS devices. Firstly, are introduced, including contact non-contact types, aiming physical, chemical biological sensing. This followed presentation advances actuators different application scenarios. Meanwhile, with ability to power other orderly enumerated. Furthermore, as representative resonators, Lamb wave resonators exhibited manifold performance improvements. Finally, trends wearable implantable devices discussed.

Language: Английский

Citations

94
Recent advances in multimode microfluidic separation of particles and cells DOI Creative Commons
Yongxin Song, Deyu Li, Xiangchun Xuan

et al.

Electrophoresis, Journal Year: 2023, Volume and Issue: 44(11-12), P. 910 - 937

Published: April 16, 2023

Abstract Microfluidic separation of particles and cells is crucial to lab‐on‐a‐chip applications in the fields science, engineering, industry. The continuous‐flow methods can be classified as active or passive depending on whether force involved process externally imposed internally induced. majority current separations have been realized using only one methods. Such a single‐mode usually limited one‐parameter separation, which often becomes less effective even ineffective when dealing with real samples because their inherent heterogeneity. Integrating two more either type has demonstrated offer several advantages like improved specificity, resolution, throughput. This article reviews recent advances such multimode particle cell microfluidic devices, including serial‐mode prefocused multistage parallel‐mode force‐tuned separation.

Language: Английский

Citations

40
Synergistically enhancing inertial particle focusing using a curved microchannel with expansion-contraction arrays DOI

Ruihan Zhuang,

Jun Zhang, Gang Chen

et al.

Particuology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I DOI Creative Commons
Sebastian Sachs, Mostafa Baloochi, Christian Cierpka

et al.

Lab on a Chip, Journal Year: 2022, Volume and Issue: 22(10), P. 2011 - 2027

Published: Jan. 1, 2022

Experimental and numerical studies on the acoustically induced fluid flow at center of pseudo-standing surface acoustic waves, as typically employed in Lab-on-a-Chip devices for particle separation.

Language: Английский

Citations

34
An ultra-compact acoustofluidic device based on the narrow-path travelling surface acoustic wave (np-TSAW) for label-free isolation of living circulating tumor cells DOI
Wenping Geng, Yukai Liu,

Nanxin Yu

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1255, P. 341138 - 341138

Published: March 27, 2023

Language: Английский

Citations

21
Integrated Microfluidics for Single‐Cell Separation and On‐Chip Analysis: Novel Applications and Recent Advances DOI Creative Commons
Hazal Kutluk, Martina Viefhues, Iordania Constantinou

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 2, 2024

From deciphering infection and disease mechanisms to identifying novel biomarkers personalizing treatments, the characteristics of individual cells can provide significant insights into a variety biological processes facilitate decision‐making in biomedical environments. Conventional single‐cell analysis methods are limited terms cost, contamination risks, sample volumes, times, throughput, sensitivity, selectivity. Although microfluidic approaches have been suggested as low‐cost, information‐rich, high‐throughput alternative conventional isolation methods, limitations such necessary off‐chip pre‐ post‐processing well systems designed for workflows restricted their applications. In this review, comprehensive overview recent advances integrated microfluidics on‐chip three prominent application domains provided: investigation somatic (particularly cancer immune cells), stem cells, microorganisms. Also, use cell separation (e.g., dielectrophoresis) unconventional or ways, which advance integration multiple systems, is discussed. Finally, critical discussion related current how they could be overcome provided.

Language: Английский

Citations

8
Inertia-magnetic microfluidics for rapid and high-purity separation of malignant tumor cells DOI

Chen Ni,

Chen Yao, Yujie Zhou

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 397, P. 134619 - 134619

Published: Sept. 22, 2023

Language: Английский

Citations

17
Acoustofluidic Tweezers Integrated with Droplet Sensing Enable Multifunctional Closed‐Loop Droplet Manipulation DOI Creative Commons
Mingyang Sui, Huijuan Dong, Guanyu Mu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Droplet manipulation technologies with surface acoustic waves attract significant attention for applications in fluid handling and bioanalysis. However, existing face challenges automation, precision, functional integration, limiting broader applications. In this work, a highly integrated droplet-sensing acoustofluidic tweezer is developed, incorporating orthogonally arranged slanted finger interdigital transducers custom-designed control detection circuit system. Using single device, enables switchable droplet detection, providing multifunctional closed-loop of on-chip microliter-scale droplets. The platform takes advantage the wideband frequency response characteristics transducers, along an automated algorithm, enabling high-precision central positions, edge contact diameters, number With feedback, various functions, including transportation, merging, mixing, splitting, internal particle enrichment, achieved first time on platform. This significantly enhances efficiency, fault tolerance process. provides innovative solution fields such as processing biosensing, demonstrating application potential.

Language: Английский

Citations

5
Controllable Size-Independent Three-Dimensional Inertial Focusing in High-Aspect-Ratio Asymmetric Serpentine Microchannels DOI

Chen Ni,

Zheng Zhou,

Zhixian Zhu

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(45), P. 15639 - 15647

Published: Oct. 31, 2022

High-throughput three-dimensional (3D) focusing of cells is the key prerequisite for enabling accurate microfluidic cell detection and analysis. In this work, we develop a high-aspect-ratio asymmetric serpentine (HARAS) microchannel single-line inertial particles at 3D center channel. The mechanism explored by numerical simulation, performances differently sized are characterized experimentally different flow rates. results demonstrate outstanding capability our HARAS microchannel. addition, phenomena size-independent position-controllable over wide rates observed. Finally, applicability processing real biological validated A549 MCF-7 cells. Our work overcomes issue off-centered most previous works provides new insights into in microfluidics. proposed extremely easy mass production may provide stable, high-throughput, scheme subsequent single-cell

Language: Английский

Citations

22