Continuous Sheathless Particle Separation in Viscoelastic Fluids with Different Rheological Properties DOI Creative Commons

Chong‐Shan Gan,

Zhuangzhuang Tian,

Lv Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Abstract The separation of particles such as cells and bacteria in viscoelastic fluids has significant applications biomedical fields. At present, one the main challenges that limit application microfluidic technology is to separate with different rheological properties. For instance, most exisiting devices can only work fluid a specific property, resulting requirement time-consuming design, manufacturing, testing, optimization In this work, new particle strategy first focusing, then initial separation, precise (FISPS) was proposed, novel hybrid three-stage device where micropore structure utilized connect two gradually contracted microchannels designed achieve efficient continuous over wide range properties (0.07 < El 340.41). showed mechanism (ISPS) at 0.14 while it > 8.43. addition, transformation from ISPS FISPS found under flow conditions transitional (0.21 1.10). effect rate property on microparticle were systematically studied by experiment. With simple structure, easy operation, high efficiency, present would have great potentials clinical applications, for patients.

Language: Английский

A Review of Research Progress in Microfluidic Bioseparation and Bioassay DOI Creative Commons
Heng Zhao, Yanyan Zhang, Dengxin Hua

et al.

Micromachines, Journal Year: 2024, Volume and Issue: 15(7), P. 893 - 893

Published: July 8, 2024

With the rapid development of biotechnology, importance microfluidic bioseparation and bioassay in biomedicine, clinical diagnosis, other fields has become increasingly prominent. Microfluidic technology, with its significant advantages high throughput, automated operation, low sample consumption, brought new breakthroughs field biological separation bioassay. In this paper, latest research progress technology is reviewed. Then, we focus on methods including active separation, passive hybrid separation. At same time, results our group particle are introduced. Finally, some application examples or for after listed, current challenges future prospects discussed.

Language: Английский

Citations

4
Flow-rate and particle-size insensitive inertial focusing in dimension-confined ultra-low aspect ratio spiral microchannel DOI
Lei Zhao,

Mengqi Gao,

Yanbing Niu

et al.

Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 369, P. 132284 - 132284

Published: July 1, 2022

Language: Английский

Citations

18
Surface acoustic wave manipulation of bioparticles DOI
Meili Qi,

Dan Dang,

Xieliu Yang

et al.

Soft Matter, Journal Year: 2023, Volume and Issue: 19(23), P. 4166 - 4187

Published: Jan. 1, 2023

The SAW technology has emerged as an important tool for manipulating bioparticles, so we introduce the recent advancements in manipulation of organisms based on standing and traveling SAWs, including separation, concentration, transport.

Language: Английский

Citations

11
Multidimensional Particle Separation by Tilted-Angle Standing Surface Acoustic Waves—Physics, Control, and Design DOI Creative Commons
Sebastian Sachs, Jörg König, Christian Cierpka

et al.

Powders, Journal Year: 2025, Volume and Issue: 4(1), P. 2 - 2

Published: Jan. 8, 2025

Lab-on-a-Chip devices based on tilted-angle standing surface acoustic waves (tasSAWs) emerged as a promising technology for multidimensional particle separation, highly selective in size and contrast factor. For this active separation method, tailored field is used to focus separate particles stationary pressure nodes by means of the radiation force. However, additional non-linear acoustofluidic phenomena, such acoustically induced fluid flow or dielectrophoretic effects, are superimposed process. To obtain high quality, control parameters that can be adjusted during process well design available. The latter specified prior span high-dimensional parameter space, ranging from wavelength dimensions materials microchannel. In paper, physical mechanisms tasSAW-based reviewed. By combining experimental, semi-analytical, numerical findings, critical channel height width derived suppress influence flow. Dealing with three-dimensional nature process, focused at different levels equal force balance implementing cover impedance while achieving an approx. three-times higher pressure. Using improved design, shape identified criterion, rendering continuous capable selectively separating microparticles below 10 μm regard size, contrast, shape.

Language: Английский

Citations

0
Chemical Conjugation of Iron Oxide Nanoparticles for the Development of Magnetically Directable Silk Particles DOI Creative Commons
Ande X. Marini,

Golnaz Najaf Tomaraei,

Justin S. Weinbaum

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Magnetically directable materials containing iron oxide nanoparticles (IONPs) have been utilized for a variety of medical applications, including localized drug delivery. Regenerated silk fibroin (RSF) has also used in numerous regenerative medicine and delivery given its biocompatibility tunable properties. In this work, we explored the hypothesis that chemically conjugating IONPs to RSF anchor microparticles would provide better magnetic guidance than nonconjugated untethered microparticles. were fabricated using coprecipitation method conjugated with glutathione (GSH) prior mixing RSF. incorporated into mixed potassium phosphate buffer fabricate without GSH characterized particle size, shape, morphology, conjugation efficiency, composition. Silk (SIMPs) composition tested stability, degradation properties, movability, cytotoxicity. demonstrated uniform size distribution spherical morphology. Conjugation was verified through changes X-ray photoelectron spectroscopy (XPS) Fourier-transform infrared (FTIR) spectra. able be SIMPs, which porous FTIR revealed an increased β-sheet content suggesting may inducing conformational fibroin. SIMPs showed stability up 4 weeks ultrapure water rapid enzymatic within 24 h. moved magnetically solution hydrogel not cytotoxic.

Language: Английский

Citations

0
Particle separation using surface acoustic waves based on microfluidic chip DOI
Wenbo Han,

Hongyuan Zou,

Han Yue

et al.

Chaos Solitons & Fractals, Journal Year: 2025, Volume and Issue: 198, P. 116557 - 116557

Published: May 16, 2025

Language: Английский

Citations

0
Acoustofluidics: A Versatile Tool for Micro/Nano Separation at the Cellular, Subcellular, and Biomolecular Levels DOI

Zhuyang Zhao,

Sha Yang, Feng Liu

et al.

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(14)

Published: May 7, 2023

Abstract Separation of micro/nanoparticles, such as cellular, subcellular and biomolecular, has attracted increasing attention because their remarkable potential applications in various fields, including chemistry, physics, medicine, etc. Among different micro/nanoparticle separation methods, acoustofluidics, which combines acoustics microfluidics, drawn the interest researchers due to its biocompatibility, high efficiency free labeling. In this review, basic constitutions, mechanisms, materials acoustofluidics are described. Subsequently, sorts delicately designed acoustofluidic devices, diverse bulk acoustic wave (BAW) microfluidics surface (SAW) discussed, covering principles, advantages, limitations separation. Besides introduction advances BAW SAW elaborated detail with a focus on configurations interdigital transducers (IDTs), comprising straight IDT, slanted‐finger chirped IDT focused IDT. Microfluidic systems involve forms channels, serpentine droplets. Additionally, besides simply structured integrated other structures also mentioned. Finally, prospects discussed. The reviewed here is envisioned versatile tool for at sub‐cellular, biomolecular levels.

Language: Английский

Citations

9
Acoustic Controllable Spatiotemporal Cell Micro-oscillation for Noninvasive Intracellular Drug Delivery DOI
Xiaoqi Gao, Dayang Li, Shukun Zhao

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(37), P. 14998 - 15007

Published: Sept. 6, 2024

Intracellular cargo delivery is crucial for drug evaluation, nanomedicine development, and gene therapy, in which high efficiency while maintaining cell viability needed downstream analysis. Here, an acoustic-mediated precise delivering mechanism proposed by directly modulating micro-oscillation mode membrane permeability. Through phase shifting keying-based spatiotemporal acoustic tweezers, controllable oscillating arrays can be achieved shaking potentials. At the same time, continually radiation force fluid shear stress exerted on cells effectively disturbs cellular mobility enhances permeability, thereby facilitating nanodrug entrance. In experiments, oscillation tunable frequency (10

Language: Английский

Citations

3
Heterogeneous tissue construction by on-demand bubble-assisted acoustic patterning DOI
Qinghao Hu, Xuejia Hu, Yang Shi

et al.

Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(9), P. 2206 - 2216

Published: Jan. 1, 2023

It offers a new strategy for the fabrication of functionalized structures variety bionic tissue models.

Language: Английский

Citations

7
On the behavior of prolate spheroids in a standing surface acoustic wave field DOI Creative Commons
Sebastian Sachs, H. Schmidt, Christian Cierpka

et al.

Microfluidics and Nanofluidics, Journal Year: 2023, Volume and Issue: 27(12)

Published: Oct. 21, 2023

Abstract The active manipulation of particle and cell trajectories in fluids by high-frequency standing surface acoustic waves (sSAW) allows to separate particles cells systematically depending on their size contrast. However, process technologies biomedical applications usually operate with non-spherical particles, for which the prediction forces is highly challenging remains a subject ongoing research. In this study, dynamical behavior prolate spheroids exposed three-dimensional field multiple pressure nodes along channel width examined. Optical measurements reveal an alignment orthogonal sSAW, has not been reported literature so far. analyzed under controlled initial conditions various motion patterns imposing phase shift sSAW. To gain detailed understanding dynamics, numerical model developed predict force torque acting spheroid. Considering acoustically induced streaming around particle, results are excellent agreement experimental findings. Using proposed model, dependence shape found relation impedance ceiling. Hence, presented herein promises high progress design separation devices utilizing exploiting additional criterion based shape.

Language: Английский

Citations

7