Terahertz ultrasensitive biosensor based on wide-area and intense light-matter interaction supported by QBIC

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 462, P. 142347 - 142347

Published: March 9, 2023

A quasi-bound state in the continuum (QBIC) has unique attraction optical switch, nonlinearity, communication, and sensing due to its ultrahigh radiation quality (Q) factor. The QBIC observed metasurfaces also provides a feasible platform achieve in-plane strong light-matter interaction, as well develop ultrasensitive biosensor. However, existing metasurface designs are difficult realize highly efficient excitation high-performance of terahertz (THz) band. Here, we manipulate interference coupling between electric quadrupole magnetic dipole by introducing an asymmetry α into metallic structure, which excites resonance with Q factor up 503. Correspondingly, light field energy constrained effective area achieved enormous increases about 400% 1300%, respectively, greatly expands spatial extent intensity interaction. Simulations experiments show that proposed deliver high refractive index sensitivity reaching 420 GHz/RIU, where RIU is unit, direct limit detection (LoD) for trace homocysteine (Hcy) molecules 12.5 pmol/μL. Its performance 40-times better than classical Dipole mode. This work new avenue rapid, precise, nondestructive molecules, potential applications fields biochemical reaction monitoring, photocatalysis photobiomodulation.

Language: Английский

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Ultra-wideband terahertz fingerprint enhancement sensing and inversion model supported by single-pixel reconfigurable graphene metasurface

PhotoniX, Journal Year: 2024, Volume and Issue: 5(1)

Published: April 15, 2024

Abstract The molecular fingerprint sensing technology based on metasurface has unique attraction in the biomedical field. However, terahertz (THz) band, existing designs multi-pixel or angle multiplexing usually require more analyte amount possess a narrower tuning bandwidth. Here, we propose novel single-pixel graphene metasurface. Based synchronous voltage tuning, this enables ultra-wideband ( $$\sim$$ ∼ 1.5 THz) enhancement of trace analytes, including chiral optical isomers, with limit detection (LoD) ≤ 0.64 μg/mm 2 . signal 17.4 dB) originates from electromagnetically induced transparency (EIT) effect excited by metasurface, and ideal overlap between light field constrained single-layer (SLG) ultra-thin analyte. Meanwhile, due to nonlinear mechanism absorption envelope distortion is inevitable. To solve problem, universal spectrum inversion model developed for first time, restoration standard fingerprints reaches R max ≥ 0.99. In addition, asynchronous provides an opportunity realizing dynamic reconfiguration EIT resonance slow modulation broadband range. This work builds bridge THz potential applications active spatial modulators, devices imaging equipments.

Language: Английский

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Passive trapping of biomolecules in hotspots with all-dielectric terahertz metamaterials

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 251, P. 116126 - 116126

Published: Feb. 12, 2024

Language: Английский

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Developments of terahertz metasurface biosensors: A literature review

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Terahertz metasurface (THz-MS) biosensor is a hybrid technology that combines terahertz time-domain spectroscopy and for the detection of biomolecules cells. Compared with traditional strategies, it label-free, non-invasive, time-saving, easy to operate. However, three fundamental issues, namely, low sensitivity, specificity, drastic water absorption, hinder development THz-MS biosensors clinical application. Recently, numerous studies have been performed solve these problems, results show great potential sensitive nucleotides, proteins, Therefore, important summarize in biomedical detection. In this review, we summarized mechanism, manufacturing, implementation biosensors. Then, strategies improve selectivity, means reduce absorption are presented. Sensitivity can be improved by suppressing electromagnetic radiation strengthening interaction between target molecules meta-atoms. Antibodies aptamers most effective improving specificity. Microfluidics hydrogels two ways absorption. Subsequently, applications nucleotide, cells summarized. Finally, prospects future outlined.

Language: Английский

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Recent Advances in Molecular and Immunological Diagnostic Platform for Virus Detection: A Review

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 490 - 490

Published: April 19, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing disease (COVID-19) outbreak and a rising demand for the development of accurate, timely, cost-effective diagnostic tests SARS-CoV-2 as well other viral infections in general. Currently, traditional virus screening methods such plate culturing real-time PCR are considered gold standard with accurate sensitive results. However, these still require sophisticated equipment, trained personnel, long analysis time. Alternatively, integration microfluidic biosensor technologies, microfluidic-based biosensors offer ability to perform sample preparation simultaneous detection many analyses one platform. High sensitivity, accuracy, portability, low cost, high throughput, can be achieved using single This review presents recent advances from works demonstrate advantages merging two technologies sensing viruses. Different platforms classified into main sections: immunoassays molecular assays. Moreover, available commercial analyzed.

Language: Английский

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Terahertz phase shift sensing and identification of a chiral amino acid based on a protein-modified metasurface through the isoelectric point and peptide bonding

Biomedical Optics Express, Journal Year: 2023, Volume and Issue: 14(3), P. 1096 - 1096

Published: Feb. 7, 2023

The efficient sensing of amino acids, especially the distinction their chiral enantiomers, is important for biological, chemical, and pharmaceutical research. In this work, a THz phase shift method was performed acid detection based on polarization-dependent electromagnetically induced transparency (EIT) metasurface. More importantly, binding specific acids to functional proteins modified metasurface developed isoelectric point theory so that recognition Arginine (Arg) achieved among four different acids. results show via high-Q shift, precision L-Arg 2.5 × 10-5 g /ml, much higher than traditional parameters. Due electrostatic adsorption by functionalized L-Arg, its sensitivity are 22 times other Furthermore, comparing nonfunctionalized metasurfaces, D- L-chiral enantiomers Arg were distinguished due abilities Therefore, EIT sensor improve both specificity in it will promote development highly sensitive enantiomers.

Language: Английский

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Enhanced Terahertz Specific Sensing for Alzheimer’s Marker by Metasurface-Analyte Union Modification on Microfluidic Sensor

IEEE Sensors Journal, Journal Year: 2024, Volume and Issue: 24(6), P. 7690 - 7699

Published: Feb. 1, 2024

Metasurface (MS)-based terahertz (THz) biosensors have attracted significant attention in the biological field due to their nondestructive and harmless interaction with biochemical samples. However, it is still challenging for specific detection mixed samples via THz metasensors. In this work, we modified MS chips target biomolecules, respectively, utilized immune binding gold nanorods (GNRs), achieved high-sensitive Alzheimer's marker $\text{A}\beta _{\text {1-42}}$ protein a microfluidic platform. A double-ring coupled metallic that can provide strong localized enhancement was fabricated then -antibody by covalent capture . Moreover, GNRs were introduced bind , sensor's response greatly enhanced. Through sensor-analytes modification, sensitivity of sensor reach 240.91 GHz notation="LaTeX">$\cdot $ mL/nmol, limit (LoD) one order magnitude higher than without GNRs. addition, LoD reached 0.2 pmol/mL (1 ng/mL), which 100 times other nonspecific proteins. More importantly, biosensor also recognize sample physiological limiting concentration. Our high selectivity nanomaterial-MS hybrid-based would give access rich applications label-free biosensing.

Language: Английский

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High Q-factor multiple Fano resonances in all-dielectric metasurface based on quasi-bound states in the continuum

Optical Review, Journal Year: 2024, Volume and Issue: 31(2), P. 194 - 202

Published: March 11, 2024

Language: Английский

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High performance THz metasurface sensor based on modified-SWCNTs film for femtomolar protein detection

Carbon, Journal Year: 2024, Volume and Issue: 227, P. 119273 - 119273

Published: May 22, 2024

Language: Английский

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Terahertz chiral enantiomers recognition via chiral selective bio-molecular film on anapole metasurface sensor in water environment

Optics & Laser Technology, Journal Year: 2023, Volume and Issue: 162, P. 109274 - 109274

Published: Feb. 16, 2023

Language: Английский

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