Recent progresses in organelle-targeting fluorescent probes for the detection of peroxynitrite DOI
Lanqing Li, Chunzheng Wang, Jinhui Hu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13629 - 13640

Published: Jan. 1, 2024

This review describes the updates and advances of ONOO − fluorescent probes from unique perspective organelle-targeting. The related design strategy, spectral responses, response mechanisms applications are thoroughly discussed.

Language: Английский

A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Detecting Peroxynitrite in Living Cells and Drosophila Brains DOI Creative Commons
Wei Wang, Jianbin Deng, Long Jin

et al.

Chemosensors, Journal Year: 2023, Volume and Issue: 11(5), P. 286 - 286

Published: May 11, 2023

Peroxynitrite (ONOO−) is a highly reactive nitrogen species (RNS) that closely associated with many physiological and pathological processes. In this study, we construct near-infrared (NIR) fluorescent probe, NAF-BN, utilizes benzyl boronic acid ester for fluorescence quenching of naphthofluorescein cores. NAF-BN has been thoroughly evaluated reliable imaging exogenous ONOO− in living cells. Further, can be applied effectively to visualize Drosophila brains, confirming the hypothesis neonicotinoid pesticides increase neurological damage oxidative stress. The probe offers exciting potential reveal role various biological medical fields.

Language: Английский

Citations

2
A Small-Molecule Fluorescent Probe for the Detection of Mitochondrial Peroxynitrite DOI Creative Commons
Dong Han, Mengyu Tang, Shi‐Li Shen

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 7976 - 7976

Published: Dec. 6, 2023

Reactive oxygen species (ROS) are pivotal signaling molecules that control a variety of physiological functions. As member the ROS family, peroxynitrite (ONOO-) possesses strong oxidation and nitrification abilities. Abnormally elevated levels ONOO- can lead to cellular oxidative stress, which may cause several diseases. In this work, based on rhodamine fluorophore, we designed synthesized novel small-molecule fluorescent probe (DH-1) for ONOO-. Upon reaction with ONOO-, DH-1 exhibited significant fluorescence signal enhancement (approximately 34-fold). Moreover, showed an excellent mitochondria-targeting capability. Confocal imaging validated its ability detect changes in HeLa RAW264.7 cells. Notably, observed generation during ferroptosis process by taking advantage probe. displayed good biocompatibility, facile synthesis, high selectivity, have potential applications study ONOO--associated diseases biosystems.

Language: Английский

Citations

2
A viscosity-sensitive probe based on the structure of indole salt DOI

Jiaying Yu,

Shen Yuan,

Xianfeng Chu

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(9), P. 3966 - 3973

Published: Jan. 1, 2024

Long-lasting and high-intensity fluorescence imaging of tumor cells.

Language: Английский

Citations

0
A long-wavelength fluorescent probe based on carbazole with AIE characteristics for the detection of ONOO− and its application DOI

Yixian Yang,

Peng Wang,

Yuan Ji

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 231, P. 112409 - 112409

Published: Aug. 15, 2024

Language: Английский

Citations

0
Recent progresses in organelle-targeting fluorescent probes for the detection of peroxynitrite DOI
Lanqing Li, Chunzheng Wang, Jinhui Hu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13629 - 13640

Published: Jan. 1, 2024

This review describes the updates and advances of ONOO − fluorescent probes from unique perspective organelle-targeting. The related design strategy, spectral responses, response mechanisms applications are thoroughly discussed.

Language: Английский

Citations

0