A novel hepatocyte-targeting fluorescent probe of rhodamine analogues to detect hypochlorite in lysosomes: Design, synthesis and evaluation

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 453, P. 115597 - 115597

Published: March 18, 2024

Language: Английский

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Probing the toxic hypochlorous acid in natural waters and biosystem by a coumarin-based fluorescence probe

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116836 - 116836

Published: Aug. 2, 2024

Since the onset of SARS-CoV-2 pandemic in early 2020, there has been a notable rise sodium hypochlorite disinfectants. Sodium undergoes hydrolysis to generate hypochlorous acid for virus eradication. This chlorine-based disinfectant is widely utilized public disinfection due its effectiveness. Although convenient, excessive and indiscriminate use can harm water environment pose risk human health. Hypochlorous acid, reactive oxygen species, plays crucial role troposphere, stratospheric chemistry, oxidizing capacity. Additionally, vital as species biological systems, irregular metabolism level associated with several illnesses. Thus, it identify comprehend environmental functions precisely. Here, we constructed new fluorescent probe, utilizing twisted intramolecular charge transfer mechanism quickly accurately detect biosystems. The probe showed increase fluorescence when exposed demonstrating excellent selectivity, fast response time (less than 10 seconds), large Stokes shift (∼ 102 nm), low detection limit 15.5 nM.

Language: Английский

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Detection and application of hypochlorous acid in both aqueous environments and living organisms

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 314, P. 124225 - 124225

Published: April 3, 2024

Language: Английский

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A selenide-based coumarin fluorescent probe for fluorescence imaging of hypochlorous acid in cells and zebrafish

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(19), P. 8809 - 8817

Published: Jan. 1, 2024

A new selenide-based fluorescent probe was developed for rapid and sensitive detection of HOCl in living cells zebrafish.

Language: Английский

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Two-Photon Nanoparticle Probe for Formaldehyde Detection via the AILE Luminescence Mechanism

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 3452 - 3459

Published: May 9, 2024

A two-photon nanoparticle probe was designed and developed based on the principle of intermolecular interaction aggregation-induced locally excited emission luminescence mechanism. The has advantages simple synthesis, convenient use, strong atomic economy, good biocompatibility, photobleaching resistance. It can produce a specific sensitive response to formaldehyde, help detect FA in normal cells cancer cells, is expected become detection for vitro vivo.

Language: Английский

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The first specific probe for pyrrolidine with multifunction by the interaction mechanism of atomic economic reaction

iScience, Journal Year: 2024, Volume and Issue: 27(7), P. 110024 - 110024

Published: May 18, 2024

Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as first specific fluorescent probe Only by adding PyD to 1, blue fluorescence at 455 nm, color solution changes from colorless yellow. The limit 1.12 × 10

Language: Английский

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A Mitochondria-Targeting Fluorescent Probe for the Dual Sensing of Hypochlorite and Viscosity without Signal Crosstalk in Living Cells and Zebrafish

Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3059 - 3059

Published: June 27, 2024

Hypochlorite (ClO−) and viscosity both affect the physiological state of mitochondria, their abnormal levels are closely related to many common diseases. Therefore, it is vitally important develop mitochondria-targeting fluorescent probes for dual sensing ClO− viscosity. Herein, we have explored a new probe, XTAP–Bn, which responds sensitively with off–on fluorescence changes at 558 765 nm, respectively. Because emission wavelength gap more than 200 XTAP–Bn can effectively eliminate signal crosstalk during simultaneous detection In addition, has several advantages, including high selectivity, rapid response, good water solubility, low cytotoxicity, excellent mitochondrial-targeting ability. More importantly, probe successfully employed monitor dynamic change in mitochondria living cells zebrafish. This study not only provides reliable tool identifying mitochondrial dysfunction but also offers potential approach early diagnosis mitochondrial-related

Language: Английский

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Photoelectrochemical sensor for hypochlorous acid detection based on the MWNTs doped PEDOT loaded with BP5 functionalized gold nanoparticles

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102230 - 102230

Published: July 27, 2024

Language: Английский

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A novel TICT-based molecular rotor: synthesis, crystal structure and application in high resolution imaging of sweat pores

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(48), P. 19424 - 19434

Published: Jan. 1, 2024

We report the synthesis and crystal structure of a naphthalimide–methoxyquinoline (NI–HQ) based molecular rotor for visualizing sweat pores without degradation dsDNA present in sweat.

Language: Английский

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A ratiometric fluorescent probe combined with smartphone technology based on cellulose for the detection of hypochlorous acid

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135943 - 135943

Published: Sept. 24, 2024

Language: Английский

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