Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 522 - 530

Published: June 27, 2024

Cyanine derivatives are organic dyes widely used for optical imaging. However, their potential in longitudinal optoacoustic imaging and photothermal therapy remains limited due to challenges such as poor chemical stability, photostability, low conversion. In this study, we present a new structural modification cyanine by introducing strongly electron-withdrawing group (barbiturate), resulting series of barbiturate-cyanine (BC810, BC885, BC1010) with suppressed fluorescence enhanced stability. Furthermore, the introduction BC1010 into block copolymers (PEG

Language: Английский

Acidic Lysosome-Anchoring Croconium-Based Nanoplatform for Enhanced Triple-Mode Bioimaging and Fe³⁺-Triggered Tumor Synergistic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(35), P. 46066 - 46078

Published: Aug. 22, 2024

Metal-modulated croconium dyes with multimodal-imaging and synergistic therapy in the tumor microenvironment have exhibited great potential theranostics. However, their unideal structure optimization always weakened efficacy of near-infrared fluorescence–photoacoustic (NIRF/PA) imaging photothermal (PTT). Here, we screened dye containing two indole groups better NIRF/PA PTT family, linked to morpholine rings, obtained CR-736, as a lysosome-targeting Fe3+-modulated agent. The established CR-736-Fe3+ nanoplatform was accurately delivered breast site, released CR-736 Fe3+ lower acidic lysosome microenvironment, activated pH-responsive NIRF/PA/magnetic resonance PTT. Furthermore, ferroptosis generated hydroxyl free radicals lipid peroxide by consuming GSH H2O2 dint accumulation cells, which resulted inhibition expression heat shock proteins concomitant recovery PTT, ferroptosis, chemodynamics further optimized maximal extent proved both vitro mouse model. This study opens new avenue designing excellent unique croconium-based nanoplatforms, synergizing multiple theranostic methods, optimizing effects microenvironment.

Language: Английский

Boosting Tumor Accumulation of Phthalocyanine through Sialylation Engineering for Superior Cancer Phototherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Phthalocyanines (Pcs) are widely developed in cancer phototherapy due to their definite chemical structure and tunable photosensitivity. However, vivo application is hampered by low water solubility non-specific biodistribution. Here,a strategy of sialylation-modulation for the first time highly improve bioavailability Pcs. The sialylated Pcs (ZnPc-4SA) not only has good hydrophilicity, but also can self-assemble into nanoparticles (ZnPc-4SA NPs). These nanoformulations retain excellent photophysical properties Pcs, which turn reflects optoacoustic phototherapeutic properties. Importantly, ZnPc-4SA NPs exhibit boosted tumor accumulation passive targeting sialic acid-mediated E-selectin targeting. Besides, phototoxicity effectively trigger cell apoptosis elimination upon laser irradiation. Therefore, sialylation engineering provides a new option hydrophobic drugs modification with enhanced theranostics.

Language: Английский