Advances on Electrochemiluminescent Biosensors for TB Biomarkers DOI Creative Commons
M. Cox, Jaymi January, Kefilwe Vanessa Mokwebo

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Tuberculosis (TB) is a highly contagious bacterial infection that remains leading cause of death and persistent threat to global health. The spread TB exacerbated by the major limitations conventional diagnostic approaches, such as complex technicalities, high cost, low sensitivity. To address these challenges, recent research has focused on using electrochemiluminescence (ECL) an alternative detection strategy coupled biosensors. ECL biosensors leverage electrochemically generated chemiluminescence, converting electrical energy light, novel transduction mechanism for This unique approach offers several advantages, namely, wide linear dynamic ranges, improved device sensitivities, prompt response times sensitive early detection. Review comprehensive overview advancements in biosensor configurations, including amplification strategies, substrates, development luminophores coreactants tailored biomarker focus designs, biorecognition elements like immunosensors, DNA sensors, aptasensors, along with various immobilization strategies target specific biomarkers. A discussion spans trends over past decade, clinical relevance, sensitivity thresholds, limits. Furthermore, widely recognized biomarkers commonly detected commercial tests are discussed alongside markers that, while not exclusive TB, have demonstrated importance. aims highlight potential ECL-based effective means advance early, reliable, accessible approach.

Language: Английский

Demonstration of asymmetric Hebbian learning based on analog resistive switching in Ag/Co3O4/p-Si memristor DOI
Indranil Maity, Richa Bharti, Ayash Kanto Mukherjee

et al.

Applied Physics Letters, Journal Year: 2025, Volume and Issue: 126(1)

Published: Jan. 2, 2025

In this work, brain-like experiential learning/forgetting ability is demonstrated with the help of various synaptic adaptation rules, namely, short-term potentiation/short-term depression, long-term potentiation/long-term spike rate-dependent plasticity, and spike-time-dependent plasticity in a thin-film device. The model device used here unidirectional thin film nanocrystalline Co3O4, grown on p-Si (100) substrate using pulsed laser deposition technique to fabricate metal–insulator–semiconductor type memristor. Along this, we found an analog bipolar-type switching behavior excellent resistive properties terms endurance, retention, ON–OFF ratio suitable for CMOS-based memory applications. conduction mechanisms are elucidated speculative band diagram formulated from UV-visible spectroscopy data.

Language: Английский

Citations

1
Advances on Electrochemiluminescent Biosensors for TB Biomarkers DOI Creative Commons
M. Cox, Jaymi January, Kefilwe Vanessa Mokwebo

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Tuberculosis (TB) is a highly contagious bacterial infection that remains leading cause of death and persistent threat to global health. The spread TB exacerbated by the major limitations conventional diagnostic approaches, such as complex technicalities, high cost, low sensitivity. To address these challenges, recent research has focused on using electrochemiluminescence (ECL) an alternative detection strategy coupled biosensors. ECL biosensors leverage electrochemically generated chemiluminescence, converting electrical energy light, novel transduction mechanism for This unique approach offers several advantages, namely, wide linear dynamic ranges, improved device sensitivities, prompt response times sensitive early detection. Review comprehensive overview advancements in biosensor configurations, including amplification strategies, substrates, development luminophores coreactants tailored biomarker focus designs, biorecognition elements like immunosensors, DNA sensors, aptasensors, along with various immobilization strategies target specific biomarkers. A discussion spans trends over past decade, clinical relevance, sensitivity thresholds, limits. Furthermore, widely recognized biomarkers commonly detected commercial tests are discussed alongside markers that, while not exclusive TB, have demonstrated importance. aims highlight potential ECL-based effective means advance early, reliable, accessible approach.

Language: Английский

Citations

0