Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening DOI
Jie Lv,

Chengcai He,

Jingcheng Cao

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Language: Английский

Fe/Cu Bimetallic Doping Carbon-Based Nanozymes with Peroxidase-Like Properties for Multimodal Determination of Neurodegenerative Related Substance Acetylcholinesterase DOI
Zhixuan Han, Nan Wang, Yuntai Lv

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Sensitive colorimetric sensing of dopamine and TYR based on enhanced HRP-like activity of CuNi/Fe LDHs nanozymes DOI

Fenghua Geng,

Min Huang, Xiaoli Zhang

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)

Published: March 1, 2025

Language: Английский

Citations

0
Multicolor Gold Clusterzyme-Enabled Construction of Ratiometric Fluorescent Sensor Array for Visual Biosensing DOI
Xiaomeng Zhou,

Saijin Huang,

Wenfeng Guo

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(47), P. 18873 - 18879

Published: Nov. 15, 2024

The simultaneous detection of multiple bioanalytes with similar structures has been a long-standing challenge for biological research and disease diagnosis. Bioreceptor-inspired sensor arrays provide an attractive competitive solution addressing this challenge, but applying technique to biosensing in practical application scenarios is complicated by many factors such as the lack robust probes, interference from matrix, difficulty on-site analysis. In work, taking advantage intrinsic fluorescence enzyme-mimic properties gold nanoclusters (AuNCs), we report design innovative ratiometric array toward enhanced fluorescent visual biosensing. With biologically important phosphates example, show that present clusterzyme-based could effectively discriminate detect eight types phosphates. particular, AuNCs three different emission colors (blue, green, red) good peroxidase-mimic were employed sensing units, presence affected both enzymatic activity these AuNCs, yielding distinct optical responses manner. Moreover, portable was established further integrating clusterzymes into hydrogel which visually identify based on their color changes. Consequently, point-of-care diagnosis urinary tract infections at levels achieved analyzing microbial ATP via strategy. This study illustrates great potential promising platform

Language: Английский

Citations

3
Interface Ligand Engineering of Au Nanoclusters with Near-infrared Boosted Peroxidase-like Activity for Total Antioxidant Capacity Analysis DOI

Chen Sun,

Yutong Ye,

Xueting Luo

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 423, P. 136837 - 136837

Published: Oct. 30, 2024

Language: Английский

Citations

0
Time-Resolved Levodopa Cascade Polymerization Tuned by Bimetallic MOF Fluorescent Nanozyme and Boric Acid for Butyrylcholinesterase Activity Dual-Mode Assay DOI
Qi Xu, Shuo Wang, Zhiwen Gan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

A ratiometric fluorescence-photothermal dual-mode assay method is constructed for the detection of butyrylcholinesterase (BChE) activity based on time-resolved levodopa (L-DOPA) cascade polymerization. First, a newly designed bimetallic metal–organic framework (MOF), Eu/Co-DPA (DPA: pyridine-2,6-dicarboxylic acid), screened out as fluorescent nanozyme with high catalytic and superior luminescence properties. In presence boric acid (BA), L-DOPA forms BA-esterified L-DOPA, which catalyzed by to form oligomers strong blue fluorescence. Meanwhile, red fluorescence quenched oligomers, generating sensitive turn-on/off response. As polymerization time increases, cleaves borate ester bonds expose catechol structures facilitates further oxidation promoting formation poly(L-DOPA) nanoparticles photothermal conversion efficiency (30.33%). Then, using thiocholine (butyrylthiocholine enzymolysis product) inhibit Eu/Co-DPA, BChE detected through change in dual signals. Both modes have low limits (0.021 0.024 U L–1) accuracy (93.3–105.3% recovery). The results real human serum indicate that both show 100.0% agreement standard method. To our knowledge, this work first combines MOFs BA regulator tune structure polymers, providing pathbreaking paradigm preparing catecholamine-based organic polymers.

Language: Английский

Citations

0
PyDNA-templated AgNPs coupled with poly (β‑cyclodextrin) enhanced fluorescence: A facile platform for signal amplification detection of biothiols in living cells and zebrafish DOI
Huijuan Yan, Mengxue Liu,

Li Mao

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 330, P. 125660 - 125660

Published: Dec. 25, 2024

Language: Английский

Citations

0
Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening DOI
Jie Lv,

Chengcai He,

Jingcheng Cao

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Language: Английский

Citations

0