Advances in Functional Nucleic Acid SERS Sensing Strategies

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Functional nucleic acids constitute a distinct category of that diverge from conventional acid amplification methodologies. They are capable forming intricate hybrid structures through Hoogsteen and reverse hydrogen bonding interactions between double-stranded single-stranded DNA, thereby broadening the spectrum DNA interactions. In recent years, functional DNA/RNA-based surface-enhanced Raman spectroscopy (SERS) has emerged as potent platform ultrasensitive multiplexed detection variety analytes interest. This review aims to elucidate operational principles several in SERS detection, including DNAzymes, G-quadruplexes, aptamers, CRISPR, origami etc., alongside design methodologies practical applications sensing. Initially, an overview is summarized encompassing structural attributes sensing mechanisms inherent diverse DNA/RNA. Following this, various innovative strategies for constructing acid-based sensors illustrated detail, aimed at improving present capabilities. A comprehensive summing up then conducted on these crucial fields, such disease diagnosis, environmental monitoring, food safety with particular focus sensitivity, specificity, analytical versatility. Finally, conclusive remarks offered along exploration existing challenges prospective avenues future research this developed field.

Language: Английский

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Advances in Multifunctional Nanoagents and SERS-Based Multimodal Sensing for Biotoxin in Foods

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1393 - 1393

Published: April 17, 2025

Biotoxins, toxic substances produced by living organisms, are widely present in food and pose a major threat to human health. Traditional detection methods, such as gas chromatography-mass spectrometry (GC-MS) enzyme-linked immunosorbent assay (ELISA), often suffer from limitations including complex sample preparation, high costs, lengthy analysis times. In response, surface-enhanced Raman spectroscopy (SERS) has emerged highly sensitive specific analytical tool for the of biotoxins. This review highlights recent progress multimodal technologies based on SERS, focusing design classification materials optimize construction SERS substrates. The integration with other modalities, fluorescence, colorimetry, electrochemistry, is discussed enhance accuracy diversity biotoxin detection. Finally, critically assesses current challenges future prospects technology, particularly real-time safety monitoring on-site diagnostics, offering critical insights guide research directions.

Language: Английский

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Cu2+-doped MIL-125 derived TiO2@C/Cu2O/CuO double Z-scheme heterostructure: A new material for sensitive and facile photoelectrochemical and colorimetric dual-mode sensing of hydrogen sulfide

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114002 - 114002

Published: May 1, 2025

Language: Английский

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Designing Schottky junction constructed from porous PdPt nanospheres embedded in Bi2S3 nanorods for ultrasensitive photoelectrochemical immunoassay of acute myocardial infarction biomarkers

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157966 - 157966

Published: Nov. 1, 2024

Language: Английский

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