Tumor organoids: applications in cancer modeling and potentials in precision medicine

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: May 12, 2022

Abstract Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity associated metastasis, relapse, and therapy resistance. These factors contribute to treatment failure an unfavorable prognosis. Personalized tumor models faithfully capturing the of individual patients are urgently needed for precision medicine. Advances in stem cell culture have given rise powerful organoid technology generation vitro three-dimensional tissues that been shown more accurately recapitulate structures, specific functions, molecular characteristics, genomic alterations, expression profiles, microenvironment primary tumors. Tumoroids serve as important component pipeline discovery potential therapeutic targets identification novel compounds. In this review, we will summarize recent advances tumoroid cultures excellent tool accurate cancer modeling. Additionally, vascularization immune modeling based on also be described. Furthermore, great organoids predicting response, investigating resistance-related mechanisms, optimizing strategies, exploring therapies. addition, bottlenecks challenges current tumoroids discussed review.

Language: Английский

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Human disease models in drug development

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(8), P. 545 - 559

Published: May 11, 2023

Language: Английский

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Precision Medicine: Disease Subtyping and Tailored Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3837 - 3837

Published: July 28, 2023

The genomics-based concept of precision medicine began to emerge following the completion Human Genome Project. In contrast evidence-based medicine, will allow doctors and scientists tailor treatment different subpopulations patients who differ in their susceptibility specific diseases or responsiveness therapies. current model was proposed precisely classify into subgroups sharing a common biological basis for more effective tailored achieve improved outcomes. Precision has become term that symbolizes new age medicine. this review, we examine history, development, future perspective We also discuss concepts, principles, tools, applications related fields. our view, work, two essential objectives need be achieved. First, classified various subtypes. Second, targeted therapies must available each disease subtype. Therefore, focused review on progress meeting these objectives.

Language: Английский

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Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 86, P. 566 - 582

Published: Dec. 18, 2021

Language: Английский

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Mapping the genomic diaspora of gastric cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 22(2), P. 71 - 84

Published: Oct. 26, 2021

Language: Английский

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