Joint association between physical exercise, caffeine intake, and biological ageing: A cross-sectional analysis of population-based study DOI Creative Commons
Guang Chen,

Siwei Zhou,

Yunqing Xun

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0323264 - e0323264

Published: May 7, 2025

Background Ageing is a significant risk factor for age-related diseases, accounting 51% of global total disease burden. As thus, promoting healthy ageing crucial. Although several potential anti-ageing drugs show promise, none have been approved purpose. The World Health Organization (WHO) recommends physical exercise exceeding 600 metabolic equivalent task (MET) minutes per week adults. However, whether positively impacts biological remains unclear. Objective This study aimed to investigate the joint correlation between MET level, caffeine consumption, and ageing. Methods We analyzed data from seven survey cycles (2007–2020) National Nutrition Examination Survey (NHANES), involving 23,739 participants. Physical activity levels were measured in week, was assessed using both PhenoAge ENABL Age algorithms. Generalized linear regression employed test correlations, adjusting confounding factors. A cubic spline model used detect non-linear relationships. Pre-specified subgroup analyses explored effect modifications, while predefined sensitivity confirmed robustness results. Results Each 100-MET increase weekly associated with 0.2-year delay (p < 0.001 Age). Individuals less than had higher accelerated compared those (mean difference [MD]: 2.2 years, 95% CI [1.5–2.8], p 0.001; MD: 2.1 [1.1–3.1], 0.001). L-shaped association observed, diminishing benefits delayed beyond 292 259 Age. Daily intake did not modify interaction > 0.05). Stronger effects observed non-Hispanic Black individuals, obesity, low-income populations, but no benefit found cancer patients. Conclusions Our findings highlight positive plateau specific thresholds. Caffeine does influence this relationship. These results underscore importance at appropriate as strategy management general population.

Language: Английский

Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain DOI Creative Commons

Matthew T. Buckley,

Eric Sun, Benson M. George

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 3(1), P. 121 - 137

Published: Dec. 19, 2022

Abstract The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop ‘aging clocks’ based on single-cell transcriptomics to characterize cell-type-specific rejuvenation. We generated transcriptomes from the subventricular zone neurogenic region 28 mice, tiling ages young old. trained single-cell-based regression models predict chronological age biological (neural stem proliferation capacity). These clocks are generalizable independent cohorts other regions brains, species. To determine if these could quantify transcriptomic rejuvenation, datasets two interventions—heterochronic parabiosis exercise. Aging revealed that heterochronic exercise reverse in regions, but different ways. This study represents first development high-resolution data demonstrates their application

Language: Английский

Citations

101
The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms DOI Creative Commons
Zoltán Ungvári, Vince Fazekas‐Pongor, Anna Csiszár

et al.

GeroScience, Journal Year: 2023, Volume and Issue: 45(6), P. 3211 - 3239

Published: July 26, 2023

Abstract Physical activity, including walking, has numerous health benefits in older adults, supported by a plethora of observational and interventional studies. Walking decreases the risk or severity various outcomes such as cardiovascular cerebrovascular diseases, type 2 diabetes mellitus, cognitive impairment dementia, while also improving mental well-being, sleep, longevity. Dose-response relationships for walking duration intensity are established adverse outcomes. Walking’s favorable effects on factors attributed to its impact circulatory, cardiopulmonary, immune function. Meeting current physical activity guidelines briskly 30 min per day 5 days can reduce several age-associated diseases. Additionally, low-intensity exercise, exerts anti-aging helps prevent age-related making it powerful tool promoting healthy aging. This is exemplified lifestyles individuals Blue Zones, regions world with highest concentration centenarians. other activities contribute significantly longevity these regions, being an integral part their daily lives. Thus, incorporating into routines encouraging walking-based interventions be effective strategy aging all populations. The goal this review provide overview vast consistent evidence supporting specific focus discuss outcomes, prevention Furthermore, will delve molecular cellular mechanisms aging, providing insights underlying biological through which beneficial effects.

Language: Английский

Citations

57
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body DOI Creative Commons
Shuhui Sun, Shuai Ma, Yusheng Cai

et al.

The Innovation, Journal Year: 2023, Volume and Issue: 4(1), P. 100380 - 100380

Published: Jan. 1, 2023

•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.

Language: Английский

Citations

48
CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells DOI Creative Commons

Tyson J. Ruetz,

Angela N. Pogson, Chloe M. Kashiwagi

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8036), P. 1150 - 1159

Published: Oct. 2, 2024

Ageing impairs the ability of neural stem cells (NSCs) to transition from quiescence proliferation in adult mammalian brain. Functional decline NSCs results decreased production new neurons and defective regeneration following injury during ageing

Language: Английский

Citations

18
Fungi, immunosenescence and cancer DOI Creative Commons
Bin Xu,

Zan Luo,

Xing Niu

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 67 - 82

Published: Jan. 7, 2025

Language: Английский

Citations

5
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging DOI
Shuai Ma,

Zhejun Ji,

Bin Zhang

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(24), P. 7025 - 7044.e34

Published: Nov. 1, 2024

Language: Английский

Citations

15
TISSUE: uncertainty-calibrated prediction of single-cell spatial transcriptomics improves downstream analyses DOI
Eric Sun, Rong Ma, Paloma Navarro Negredo

et al.

Nature Methods, Journal Year: 2024, Volume and Issue: 21(3), P. 444 - 454

Published: Feb. 12, 2024

Language: Английский

Citations

10
Insights and Interventions in Age-Associated Inflammation DOI
Haoyan Huang, Jie Ren, Guang‐Hui Liu

et al.

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 91, P. 102306 - 102306

Published: Jan. 20, 2025

Language: Английский

Citations

1
Dissecting endothelial cell heterogeneity with new tools DOI Creative Commons
Jing Zhong,

Rongrong Gao,

Xin Zhang

et al.

Cell Regeneration, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 23, 2025

Abstract The formation of a blood vessel network is crucial for organ development and regeneration. Over the past three decades, central molecular mechanisms governing growth have been extensively studied. Recent evidence indicates that vascular endothelial cells—the specialized cells lining inner surface vessels—exhibit significant heterogeneity to meet specific needs different organs. This review focuses on current understanding cell heterogeneity, which includes both intra-organ inter-organ heterogeneity. Intra-organ encompasses arterio-venous tip-stalk specialization, while refers organ-specific transcriptomic profiles functions. Advances in single-cell RNA sequencing (scRNA-seq) enabled identification new subpopulations comparison gene expression patterns across subsets cells. Integrating scRNA-seq with other high-throughput technologies promises deepen our at epigenetic level spatially resolved context. To further explore human organoids offer powerful tools studying function three-dimensional culture systems investigating endothelial-tissue interactions using Developing presents unique opportunities unravel its implications disease. Emerging technologies, such as organoids, are poised transform pave way innovative therapeutic strategies address diseases. Graphical

Language: Английский

Citations

1
Molecular aspects of the exercise response and training adaptation in skeletal muscle DOI Creative Commons
Regula Furrer, Christoph Handschin

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 53 - 68

Published: July 24, 2024

Skeletal muscle plasticity enables an enormous potential to adapt various internal and external stimuli perturbations. Most notably, changes in contractile activity evoke a massive remodeling of biochemical, metabolic force-generating properties. In recent years, large number signals, sensors, regulators effectors have been implicated these adaptive processes. Nevertheless, our understanding the molecular underpinnings training adaptation remains rudimentary. Specifically, mechanisms that underlie signal integration, output coordination, functional redundancy other complex traits are unknown. fact, it is even unclear how stimulus-dependent specification brought about endurance or resistance exercise. this review, we will provide overview on events describe acute perturbations single exercise bouts. Furthermore, insights into principles long-term adaptation. Finally, current gaps knowledge be identified, strategies for multi-omic –cellular analyses skeletal engaged individual, bouts chronic discussed.

Language: Английский

Citations

7